INT38550

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Context Info
Confidence 0.02
First Reported 1986
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 1.06
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
erythrocyte 1
nerves 1
IGKV2-19 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 2 99.76 Very High Very High Very High
antagonist 2 99.28 Very High Very High Very High
Arthritis 66 96.08 Very High Very High Very High
Thoracotomy 1 94.40 High High
Neurotransmitter 2 86.84 High High
rheumatoid arthritis 76 82.72 Quite High
tetrodotoxin 1 82.64 Quite High
Inflammation 4 5.00 Very Low Very Low Very Low
methotrexate 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arthritis 66 96.08 Very High Very High Very High
Disease 50 88.00 High High
Rheumatoid Arthritis 76 82.72 Quite High
INFLAMMATION 4 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Spondylarthropathies 2 5.00 Very Low Very Low Very Low
Communicable Diseases 2 5.00 Very Low Very Low Very Low
Syndrome 2 5.00 Very Low Very Low Very Low
Seronegative Spondarthritis 2 5.00 Very Low Very Low Very Low
Osteoarthritis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
can be multiplied by the increase in anti-MCV levels to calculate the increase in DAS28.
Positive_regulation (increase) of DAS28
1) Confidence 0.02 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374444 Disease Relevance 0.30 Pain Relevance 0.11
Anti-MCV-positive early arthritis patients had significantly higher Sharp-van der Heijde score, erythrocyte sedimentation rate and C-reactive protein levels than did anti-MCV-negative patients at all time points (P < 0.005), but DAS28 was higher in anti-MCV-positive patients at 2 years of follow up only (P < 0.05).


Positive_regulation (higher) of DAS28 in erythrocyte associated with arthritis
2) Confidence 0.02 Published 2008 Journal Arthritis Res Ther Section Abstract Doc Link PMC2374444 Disease Relevance 0.76 Pain Relevance 0.22
We have also studied a related peptide, peptide histidine methionine (PHM), which coexists with VIP in human airway nerves, and in separate experiments studied fragments of the VIP amino acid sequence (VIP1-10 and VIP16-28) for agonist and antagonist activity.
Positive_regulation (fragments) of VIP16-28 in nerves associated with antagonist and agonist
3) Confidence 0.02 Published 1986 Journal J. Appl. Physiol. Section Abstract Doc Link 3781947 Disease Relevance 0 Pain Relevance 0.27

General Comments

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