INT38556

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Context Info
Confidence 0.50
First Reported 1987
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 47
Total Number 50
Disease Relevance 12.52
Pain Relevance 5.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (DBT) small molecule metabolic process (DBT) transferase activity, transferring acyl groups (DBT)
cellular nitrogen compound metabolic process (DBT) cytoplasm (DBT)
Anatomy Link Frequency
follicle 4
plasma 2
MCF-7 2
endometrium 2
capsule 1
DBT (Homo sapiens)
DBT - K252Q (2) DBT - R178H (1)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 410 99.32 Very High Very High Very High
antagonist 466 99.22 Very High Very High Very High
Osteoarthritis 251 99.04 Very High Very High Very High
agonist 488 98.96 Very High Very High Very High
Kinase C 38 96.08 Very High Very High Very High
diclofenac 34 94.64 High High
corticosteroid 84 94.12 High High
COX2 52 93.80 High High
Inflammatory response 30 92.60 High High
Infliximab 40 92.44 High High
Disease Link Frequency Relevance Heat
Breast Cancer 150 99.66 Very High Very High Very High
Rheumatoid Arthritis 422 99.32 Very High Very High Very High
Frailty 250 99.04 Very High Very High Very High
Rupture 21 98.42 Very High Very High Very High
Testicular Cancer 1 98.40 Very High Very High Very High
Togavirus Infection 189 98.36 Very High Very High Very High
Contracture 20 96.96 Very High Very High Very High
Acid Reflux 18 96.02 Very High Very High Very High
Obesity 124 96.00 Very High Very High Very High
Disease 252 94.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, our case demonstrates that normal unstimulated circulating E2 levels do not allow the presence of a stromal testicular tumour to be ruled out and that the response of restored T levels to hCG testing can remain blunted up to 1 year after surgery.
Gene_expression (levels) of E2 associated with testicular cancer
1) Confidence 0.50 Published 2005 Journal Andrologia Section Abstract Doc Link 15644061 Disease Relevance 0.60 Pain Relevance 0.07
Luteal phase levels of E2 and progesterone measured daily were significantly elevated (P less than 0.01) in CC-treated cycles.
Gene_expression (levels) of E2
2) Confidence 0.39 Published 1987 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 3782428 Disease Relevance 0 Pain Relevance 0.15
As the present study employed a single dose injection of rhFSH, the serum FSH level elaborated may not sustain enough to override the window of threshold for proper follicular growth and there were only transiently elevated levels of E2 detected in both groups.
Gene_expression (detected) of E2
3) Confidence 0.35 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2764710 Disease Relevance 0 Pain Relevance 0
Studies have shown that some drugs administered vaginally may provide rapid and complete systemic absorption and much higher levels of both E2 and estrone were found following the vaginal dose compared to the oral dose [26].
Gene_expression (levels) of E2
4) Confidence 0.27 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2764710 Disease Relevance 0 Pain Relevance 0
It is now well established that breast cancer cell line MCF-7 expresses E2 receptors (ER+), and that 17-?
Gene_expression (expresses) of E2 in MCF-7 associated with breast cancer
5) Confidence 0.20 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2887400 Disease Relevance 0.88 Pain Relevance 0.07
PE [14], especially in view of recent data in breast cancer cells that demonstrate the importance of FOXO1A in E2 action [16].
Gene_expression (action) of E2 associated with breast cancer
6) Confidence 0.20 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1775064 Disease Relevance 0.10 Pain Relevance 0
During the proliferative phase, endometrium is stimulated by high levels of circulating E2, and then after ovulation in the early secretory phase, it is the target of low, but rising, circulating levels of P (and E2).
Gene_expression (levels) of E2 in endometrium
7) Confidence 0.20 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1775064 Disease Relevance 0 Pain Relevance 0
With regard to E2-regulated genes, insight into these derive from a recent study on gene expression in human endometrium in late PE (LPE, high E2) compared to menstrual endometrium (very low E2 levels) and E2-treated endometrial explants, using the same Affymetrix platform [10].
Gene_expression (levels) of E2 in endometrium
8) Confidence 0.17 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1775064 Disease Relevance 0 Pain Relevance 0
Surprisingly, levels of E2, E3, and 16?
Gene_expression (levels) of E2
9) Confidence 0.13 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1257423 Disease Relevance 1.55 Pain Relevance 0.77
In addition to studying the AUC for E2 levels [45,46], we looked at the E2 production per mature follicle and per gonadotropin dose administered during COH [48] and the effect of age on these parameters [47].
Gene_expression (production) of E2 in follicle
10) Confidence 0.13 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266397 Disease Relevance 0.13 Pain Relevance 0
In rhesus monkey, supraphysiological doses of estrogen given in the mid or late follicular phase induce atresia or luteinization without rupture of the dominant follicle, reduce the viability of granulosa cells, reduce the synthesis of E2 and progesterone and are detrimental to the oocyte [248].
Gene_expression (synthesis) of E2 in granulosa cells associated with rupture
11) Confidence 0.13 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266397 Disease Relevance 0.30 Pain Relevance 0.03
They used the aromatase inhibitor, 4-hydroxyandrostenedione (4-OHA), to inhibit endogenous E2 production.
Gene_expression (production) of E2
12) Confidence 0.13 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266397 Disease Relevance 0 Pain Relevance 0
Both GnRH antagonists had no effect on basal or hCG-induced E2 or progesterone production by granulose lutein cells, independent of whether the cells were exposed to the compounds in vitro or in vivo.
Gene_expression (production) of E2 in lutein cells associated with antagonist
13) Confidence 0.13 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266397 Disease Relevance 0 Pain Relevance 0.39
-dihydro-ASD, testosterone, and negligible amounts of E1, E2, E3, and 16?
Gene_expression (amounts) of E2
14) Confidence 0.12 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257423 Disease Relevance 0.37 Pain Relevance 0.29
-dihydro-ASD, testosterone, and negligible amounts of E1, E2, E3, or 16?
Gene_expression (amounts) of E2
15) Confidence 0.12 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1257423 Disease Relevance 1.62 Pain Relevance 0.81
Interestingly, levels of testosterone were similar as compared with E2, combined E3 and 16?
Gene_expression (combined) of E2
16) Confidence 0.12 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257423 Disease Relevance 0.67 Pain Relevance 0.46
Interestingly, levels of testosterone were similar as compared with E2, combined E3 and 16?
Gene_expression (compared) of E2
17) Confidence 0.12 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257423 Disease Relevance 0.68 Pain Relevance 0.46
Despite the drastic reduction in the circulating levels of E2 and the increase in the circulating levels of androgens, the overall number of large antral follicles [16 ± 3 for controls and 20 ± 3 for ATD-treated] and their size distribution (as assessed by ultrasonography) proved comparable for control and ATD-treated animals.
Gene_expression (levels) of E2 in follicles
18) Confidence 0.10 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266397 Disease Relevance 0 Pain Relevance 0
There were 53% and 70% reductions in the basal and surge levels of E2, respectively without obvious effect on follicular maturation, ovulation, and luteal function as assessed by serum hormone profiles as well as by laparotomy.
Gene_expression (levels) of E2
19) Confidence 0.10 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266397 Disease Relevance 0 Pain Relevance 0
They found that in uncapacitated cells, E2 at 00.001 ?
Gene_expression (found) of E2
20) Confidence 0.09 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266397 Disease Relevance 0.05 Pain Relevance 0

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