INT38557

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Context Info
Confidence 0.37
First Reported 1987
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 8
Total Number 10
Disease Relevance 2.05
Pain Relevance 0.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (DBT) small molecule metabolic process (DBT) transferase activity, transferring acyl groups (DBT)
cellular nitrogen compound metabolic process (DBT) cytoplasm (DBT)
Anatomy Link Frequency
plasma 4
LES 2
lutein cells 2
endometrium 2
DBT (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 46 99.38 Very High Very High Very High
agonist 115 89.72 High High
Endogenous opioid 2 85.36 High High
Inflammation 67 79.56 Quite High
Pain 10 74.28 Quite High
Kinase C 24 60.40 Quite High
Calcium channel 28 33.68 Quite Low
GABA receptor 2 30.80 Quite Low
Opioid 2 29.92 Quite Low
GABAergic 12 28.56 Quite Low
Disease Link Frequency Relevance Heat
Testicular Cancer 2 98.40 Very High Very High Very High
Acid Reflux 18 96.34 Very High Very High Very High
Macromastia 2 94.80 High High
Cancer 22 89.72 High High
Adenocarcinoma 6 81.68 Quite High
INFLAMMATION 72 79.56 Quite High
Stress 21 77.24 Quite High
Hypogonadotropic Hypogonadism 3 76.80 Quite High
Congenital Anomalies 16 75.00 Quite High
Metaplasia 4 71.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, our case demonstrates that normal unstimulated circulating E2 levels do not allow the presence of a stromal testicular tumour to be ruled out and that the response of restored T levels to hCG testing can remain blunted up to 1 year after surgery.
Positive_regulation (circulating) of Gene_expression (levels) of E2 associated with testicular cancer
1) Confidence 0.37 Published 2005 Journal Andrologia Section Abstract Doc Link 15644061 Disease Relevance 0.60 Pain Relevance 0.07
In addition, our case demonstrates that normal unstimulated circulating E2 levels do not allow the presence of a stromal testicular tumour to be ruled out and that the response of restored T levels to hCG testing can remain blunted up to 1 year after surgery.
Positive_regulation (unstimulated) of Gene_expression (levels) of E2 associated with testicular cancer
2) Confidence 0.37 Published 2005 Journal Andrologia Section Abstract Doc Link 15644061 Disease Relevance 0.60 Pain Relevance 0.07
Luteal phase levels of E2 and progesterone measured daily were significantly elevated (P less than 0.01) in CC-treated cycles.
Positive_regulation (elevated) of Gene_expression (levels) of E2
3) Confidence 0.31 Published 1987 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 3782428 Disease Relevance 0 Pain Relevance 0.16
As the present study employed a single dose injection of rhFSH, the serum FSH level elaborated may not sustain enough to override the window of threshold for proper follicular growth and there were only transiently elevated levels of E2 detected in both groups.
Positive_regulation (elevated) of Gene_expression (detected) of E2
4) Confidence 0.23 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2764710 Disease Relevance 0 Pain Relevance 0
During the proliferative phase, endometrium is stimulated by high levels of circulating E2, and then after ovulation in the early secretory phase, it is the target of low, but rising, circulating levels of P (and E2).
Positive_regulation (stimulated) of Gene_expression (levels) of E2 in endometrium
5) Confidence 0.15 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1775064 Disease Relevance 0 Pain Relevance 0
Both GnRH antagonists had no effect on basal or hCG-induced E2 or progesterone production by granulose lutein cells, independent of whether the cells were exposed to the compounds in vitro or in vivo.
Neg (independent) Spec (whether) Positive_regulation (induced) of Gene_expression (production) of E2 in lutein cells associated with antagonist
6) Confidence 0.08 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266397 Disease Relevance 0 Pain Relevance 0.39
Measurement of P4 and estradiol (E2) levels
Positive_regulation (Measurement) of Gene_expression (estradiol) of E2
7) Confidence 0.05 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC305330 Disease Relevance 0 Pain Relevance 0
may be differentially recruited to plasma membrane after E2 exposure, because translocation of ER?
Positive_regulation (because) of Gene_expression (exposure) of E2 in plasma
8) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2910705 Disease Relevance 0 Pain Relevance 0.06
may be differentially recruited to plasma membrane after E2 exposure, because translocation of ER?
Positive_regulation (after) of Gene_expression (exposure) of E2 in plasma
9) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2910705 Disease Relevance 0 Pain Relevance 0.06
Cheng et al. reported that in a cat model of hydrochloric acid reflux, hydrogen peroxide was induced by an increase of IL-1 in the LES, after which it inhibited the release of acetylcholine from cholinergic nerve terminals and caused LES relaxation by stimulating the synthesis of prostaglandin (PG) E2 and platelet-activating factor (PAF) [31, 32].
Positive_regulation (stimulating) of Gene_expression (synthesis) of E2 in LES associated with acid reflux
10) Confidence 0.03 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2291500 Disease Relevance 0.85 Pain Relevance 0.10

General Comments

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