INT38564

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Context Info
Confidence 0.38
First Reported 1986
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 36
Total Number 40
Disease Relevance 27.77
Pain Relevance 9.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
soma 3
spinal 1
joint 1
nodes 1
neurons 1
AIS (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 295 100.00 Very High Very High Very High
Pain 134 99.98 Very High Very High Very High
anesthesia 274 99.92 Very High Very High Very High
cva 111 99.90 Very High Very High Very High
backache 29 99.80 Very High Very High Very High
Nav1.6 20 99.48 Very High Very High Very High
agonist 25 98.78 Very High Very High Very High
sodium channel 159 98.44 Very High Very High Very High
analgesia 15 98.16 Very High Very High Very High
Arthritis 7 97.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Scoliosis 1452 100.00 Very High Very High Very High
Stroke 169 100.00 Very High Very High Very High
Arthralgia 120 99.98 Very High Very High Very High
Cv General 3 Under Development 64 99.90 Very High Very High Very High
Thrombosis 158 99.84 Very High Very High Very High
Pain 122 99.80 Very High Very High Very High
Low Back Pain 29 99.80 Very High Very High Very High
Breast Cancer 334 99.32 Very High Very High Very High
Injury 38 99.26 Very High Very High Very High
Thromboembolism 4 99.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
AIS is associated with pubertal growth spurt and its progression decelerates after completion of skeletal maturity.
AIS Binding (associated) of associated with scoliosis
1) Confidence 0.38 Published 2006 Journal Scoliosis Section Body Doc Link PMC1501058 Disease Relevance 0.41 Pain Relevance 0
Mechanism of action of AIs and other hormone therapies for breast cancer
AIs Binding (action) of associated with breast cancer
2) Confidence 0.32 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682397 Disease Relevance 0.48 Pain Relevance 0.03
Clinical experience suggests that the treatment with AIs is associated with a novel musculoskeletal side effect consisting of an arthralgia syndrome which sometimes can be a reason for discontinuation of AIs treatment.
AIs Binding (associated) of associated with arthralgia and syndrome
3) Confidence 0.32 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682397 Disease Relevance 1.18 Pain Relevance 0.13
For the patient with AIS and the nurse/clinician it is particularly important to define the early therapeutic prognosis because treatment can be long and difficult [55].
AIS Binding (patient) of associated with scoliosis
4) Confidence 0.31 Published 2005 Journal Chiropr Osteopat Section Body Doc Link PMC1325030 Disease Relevance 0.82 Pain Relevance 0
The only device for interaction between the anesthesiologist and the AIS is a touch-sensitive, high-resolution color display screen.
AIS Binding (interaction) of
5) Confidence 0.31 Published 1986 Journal J Clin Monit Section Abstract Doc Link 3783196 Disease Relevance 0 Pain Relevance 0.34
A questionnaire and an analogue visual scale graduated from 0 (no pain) to 100 (maximal pain) were used in order to verify more precisely, the importance of the association between AIS and back pain.
AIS Binding (association) of associated with pain and backache
6) Confidence 0.31 Published 1996 Journal Ann Chir Section Abstract Doc Link 9035437 Disease Relevance 1.37 Pain Relevance 0.91
Association between AIS and pain is more frequent than generally reported.
AIS Binding (Association) of associated with pain
7) Confidence 0.31 Published 1996 Journal Ann Chir Section Abstract Doc Link 9035437 Disease Relevance 1.54 Pain Relevance 1.06
Piercing injuries from consumer-related products were associated with the highest AIS scores (median = 2.5).
AIS Binding (associated) of associated with injury
8) Confidence 0.31 Published 1996 Journal Pediatr Emerg Care Section Abstract Doc Link 8859913 Disease Relevance 1.12 Pain Relevance 0.08
Overall, AIs are associated with a small but significant improvement in disease free survival.
AIs Binding (associated) of associated with disease
9) Confidence 0.31 Published 2008 Journal Clinical Interventions in Aging Section Abstract Doc Link PMC2682397 Disease Relevance 0.53 Pain Relevance 0
To sum up, AIs are associated with lower thrombotic risk when compared with tamoxifen, while the possible unfavorable balance of AIs on cardiovascular risk needs to be confirmed.


AIs Binding (associated) of
10) Confidence 0.31 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682397 Disease Relevance 1.07 Pain Relevance 0.09
a) Can you apply such a radiological technique to the vertebrae of subjects with AIS?
AIS Binding (subjects) of in vertebrae associated with scoliosis
11) Confidence 0.29 Published 2008 Journal Scoliosis Section Body Doc Link PMC2474583 Disease Relevance 0.37 Pain Relevance 0.07
We are working on a larger number of patients and planning a longitudinal study involving analyses between multiple variables (Moderator: Dr Chu and colleagues have recently published their findings for spinal cord morphology in 97 AIS girls, and 36 age-matched controls [4]).


AIS Binding (findings) of in spinal cord associated with scoliosis and spinal cord
12) Confidence 0.29 Published 2008 Journal Scoliosis Section Body Doc Link PMC2474583 Disease Relevance 0.79 Pain Relevance 0.21
The statistical findings for the 28 AIS patients (14 mild, 14 severe curves) are:
AIS Binding (findings) of associated with scoliosis
13) Confidence 0.29 Published 2008 Journal Scoliosis Section Body Doc Link PMC2474583 Disease Relevance 1.01 Pain Relevance 0.36
Non-steroidal AIs reversibly bind to the aromatase enzyme and include anastrozole and letrozole.
AIs Binding (bind) of
14) Confidence 0.28 Published 2007 Journal International Journal of Clinical Practice Section Body Doc Link PMC2228389 Disease Relevance 1.32 Pain Relevance 0.19
AIs are associated with hot flushes, but the proportion of women who exhibit vasomotor instability may be less than that seen with tamoxifen treatment (31,39).
AIs Binding (associated) of
15) Confidence 0.28 Published 2007 Journal International Journal of Clinical Practice Section Body Doc Link PMC2228389 Disease Relevance 0.59 Pain Relevance 0.16
The purpose of this argument is to demonstrate that 1) spinal deformity associated with AIS can increase, 2) specific risk factors have been identified that reliably predict curves at risk for progression, 3) the natural history of untreated, progressive scoliosis is unfavorable and, 4) surgical treatment of progressive AIS is safe, consistently achieves the goals of treatment, and favorably alters an otherwise negative natural history in a measurable fashion (figures 1, 2, 3).
AIS Binding (associated) of in spinal associated with scoliosis
16) Confidence 0.28 Published 2008 Journal Patient Saf Surg Section Body Doc Link PMC2572584 Disease Relevance 0.66 Pain Relevance 0
Discussion centred on several key concerns which health care providers felt were most important to the development of an outstanding online information and support resource for adolescents considering surgery for AIS and their parents:

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AIS Binding (parents) of associated with scoliosis
17) Confidence 0.27 Published 2010 Journal Scoliosis Section Body Doc Link PMC2911416 Disease Relevance 0.10 Pain Relevance 0
The aim of this study was to develop an online information and support resource for AIS patients considering surgery and their families.
AIS Binding (resource) of associated with scoliosis
18) Confidence 0.27 Published 2010 Journal Scoliosis Section Body Doc Link PMC2911416 Disease Relevance 0.27 Pain Relevance 0
Neoadjuvant trials with antihormone therapy have generally shown that the chance of breast conservation is higher with AIs than tamoxifen and may be higher for AIs than for chemotherapy in women with hormone receptor positive tumours (19–22).
AIs Binding (higher) of associated with cancer
19) Confidence 0.22 Published 2007 Journal International Journal of Clinical Practice Section Body Doc Link PMC2228389 Disease Relevance 0.64 Pain Relevance 0
The purpose of this article is to provide primary care physicians with a basic understanding of AIs to help facilitate these interactions.


AIs Binding (interactions) of
20) Confidence 0.22 Published 2007 Journal International Journal of Clinical Practice Section Body Doc Link PMC2228389 Disease Relevance 0.37 Pain Relevance 0

General Comments

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