INT38573

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Context Info
Confidence 0.46
First Reported 1984
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 2.11
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Mb)
Anatomy Link Frequency
platelet 6
blood 2
chest 2
heart 2
Mb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Angina 17 99.40 Very High Very High Very High
algil 1 46.72 Quite Low
Opioid 1 46.28 Quite Low
Paracetamol 1 45.44 Quite Low
aspirin 1 44.48 Quite Low
cINOD 5 43.56 Quite Low
Inflammatory response 2 10.80 Low Low
cytokine 14 6.32 Low Low
chemokine 9 5.00 Very Low Very Low Very Low
ischemia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myocardial Infarction 38 99.84 Very High Very High Very High
Rhabdomyolysis 4 99.84 Very High Very High Very High
Angina 5 99.40 Very High Very High Very High
Coronary Artery Disease 3 98.92 Very High Very High Very High
Emergencies 7 97.28 Very High Very High Very High
Cv General 3 Under Development 12 97.24 Very High Very High Very High
Renal Failure 2 91.60 High High
Diuresis 3 89.84 High High
Cv Unclassified Under Development 3 80.24 Quite High
Acute Coronary Syndrome 3 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased serum myoglobin levels were detected by radioimmunoassay in 57 (71.8%) of 80 patients with unstable angina.
Positive_regulation (Increased) of Gene_expression (levels) of myoglobin associated with angina
1) Confidence 0.46 Published 1986 Journal Kardiologiia Section Abstract Doc Link 3784264 Disease Relevance 0.17 Pain Relevance 0.25
The myoglobin concentration, creatine kinase and creatine kinase sub-unit B activity were estimated in fourteen patients with ischaemic heart disease before and after exercise induced angina pectoris.
Positive_regulation (estimated) of Gene_expression (concentration) of myoglobin in heart associated with angina and coronary artery disease
2) Confidence 0.27 Published 1984 Journal Scand. J. Clin. Lab. Invest. Section Abstract Doc Link 6528213 Disease Relevance 0.27 Pain Relevance 0.10
STUDY OBJECTIVE: Limited information is available about the diagnostic performance of creatine kinase (CK)-MB and myoglobin levels during the early evaluation of chest pain patients using cardiac troponins as the criterion standard for diagnosing acute myocardial infarction.
Positive_regulation (performance) of Gene_expression (levels) of myoglobin in chest associated with angina and myocardial infarction
3) Confidence 0.13 Published 2004 Journal Ann Emerg Med Section Abstract Doc Link 15226704 Disease Relevance 0.35 Pain Relevance 0.10
RESULTS: The following cut-off values for prediction of cardiac events were calculated: troponin I at baseline 0.3 ng/ml (predictive accuracy=0.870), troponin I at 6 h 0.50 ng/ml (p.a.=0.909); troponin T at baseline 0.05 ng/ml (p.a.=0.643), troponin T at 6 h 0.05 ng/ml (p.a.=0.612), creatine phosphokinase myocardial fraction at baseline 2.0 ng/ml (p.a.=0.721), creatine phosphokinase myocardial fraction at 6 h 2.5 ng/ml (p.a.=0.734), myoglobin at baseline 23 ng/ml (p.a.=0.623), myoglobin at 6 h 26 ng/ml (p.a.=0.617), C-reactive protein at baseline 0.31 mg/dl (p.a.=0.662), C-reactive protein at 6 h 0.55 mg/dl (p.a.=0.682), and fibrinogen at baseline 360 mg/dl (p.a.=0.701).
Positive_regulation (calculated) of Gene_expression (fraction) of myoglobin
4) Confidence 0.11 Published 2005 Journal Int. J. Cardiol. Section Body Doc Link 15771924 Disease Relevance 0.16 Pain Relevance 0
RESULTS: The following cut-off values for prediction of cardiac events were calculated: troponin I at baseline 0.3 ng/ml (predictive accuracy=0.870), troponin I at 6 h 0.50 ng/ml (p.a.=0.909); troponin T at baseline 0.05 ng/ml (p.a.=0.643), troponin T at 6 h 0.05 ng/ml (p.a.=0.612), creatine phosphokinase myocardial fraction at baseline 2.0 ng/ml (p.a.=0.721), creatine phosphokinase myocardial fraction at 6 h 2.5 ng/ml (p.a.=0.734), myoglobin at baseline 23 ng/ml (p.a.=0.623), myoglobin at 6 h 26 ng/ml (p.a.=0.617), C-reactive protein at baseline 0.31 mg/dl (p.a.=0.662), C-reactive protein at 6 h 0.55 mg/dl (p.a.=0.682), and fibrinogen at baseline 360 mg/dl (p.a.=0.701).
Positive_regulation (calculated) of Gene_expression (fraction) of myoglobin
5) Confidence 0.11 Published 2005 Journal Int. J. Cardiol. Section Body Doc Link 15771924 Disease Relevance 0.16 Pain Relevance 0
Initial blood samples were drawn for H-FABP, myoglobin, creatine kinase isoenzyme MB (CK-MB), and cardiac troponin-I (cTnI) measurements.
Positive_regulation (measurements) of Gene_expression (drawn) of myoglobin in blood
6) Confidence 0.09 Published 2011 Journal Journal of Korean Medical Science Section Abstract Doc Link PMC3012849 Disease Relevance 0.73 Pain Relevance 0.10
Secondary end points were periprocedural MI; periprocedural creatine kinase-MB elevation >3 x upper limit of normal; any periprocedural increase of creatine kinase-MB, troponin-I, or myoglobin above upper limit of normal; Thrombolysis in Myocardial Infarction flow <3 after PCI; thrombocytopenia with platelet count of <70,000/mL; major bleeding defined according to the Thrombolysis in Myocardial Infarction criteria; and elevation of high-sensitivity C-reactive protein and soluble P selectin.
Positive_regulation (elevation) of Gene_expression (troponin-I) of myoglobin in platelet
7) Confidence 0.03 Published 2009 Journal Am. Heart J. Section Body Doc Link 19781418 Disease Relevance 0 Pain Relevance 0
Secondary end points were periprocedural MI; periprocedural creatine kinase-MB elevation >3 x upper limit of normal; any periprocedural increase of creatine kinase-MB, troponin-I, or myoglobin above upper limit of normal; Thrombolysis in Myocardial Infarction flow <3 after PCI; thrombocytopenia with platelet count of <70,000/mL; major bleeding defined according to the Thrombolysis in Myocardial Infarction criteria; and elevation of high-sensitivity C-reactive protein and soluble P selectin.
Positive_regulation (increase) of Gene_expression (troponin-I) of myoglobin in platelet
8) Confidence 0.03 Published 2009 Journal Am. Heart J. Section Body Doc Link 19781418 Disease Relevance 0 Pain Relevance 0
Secondary end points were periprocedural MI; periprocedural creatine kinase-MB elevation >3 x upper limit of normal; any periprocedural increase of creatine kinase-MB, troponin-I, or myoglobin above upper limit of normal; Thrombolysis in Myocardial Infarction flow <3 after PCI; thrombocytopenia with platelet count of <70,000/mL; major bleeding defined according to the Thrombolysis in Myocardial Infarction criteria; and elevation of high-sensitivity C-reactive protein and soluble P selectin.
Positive_regulation (periprocedural) of Gene_expression (troponin-I) of myoglobin in platelet
9) Confidence 0.03 Published 2009 Journal Am. Heart J. Section Body Doc Link 19781418 Disease Relevance 0 Pain Relevance 0
Multiple organ dysfunction and secondary rhabdomyolysis led to increased levels of myoglobin and CK (myoglobin peak level 33.124 ?
Positive_regulation (increased) of Gene_expression (levels) of myoglobin associated with rhabdomyolysis
10) Confidence 0.03 Published 2005 Journal Crit Care Section Body Doc Link PMC1297610 Disease Relevance 0.28 Pain Relevance 0

General Comments

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