INT38574

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Context Info
Confidence 0.47
First Reported 1982
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 3.64
Pain Relevance 1.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (Ache) extracellular space (Ache) extracellular region (Ache)
cell adhesion (Ache) Golgi apparatus (Ache) plasma membrane (Ache)
Anatomy Link Frequency
brain 1
brainstem 1
synapse 1
Ache (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 15 99.68 Very High Very High Very High
Clonidine 7 99.24 Very High Very High Very High
medulla 3 94.84 High High
narcan 1 94.84 High High
antinociception 4 93.60 High High
Antinociceptive 3 91.68 High High
gABA 4 91.04 High High
GABA receptor 1 83.60 Quite High
antagonist 7 82.48 Quite High
Enkephalin 1 78.68 Quite High
Disease Link Frequency Relevance Heat
Amyloid Plaque 16 99.76 Very High Very High Very High
Disease 553 99.20 Very High Very High Very High
Toxicity 13 97.20 Very High Very High Very High
Cognitive Disorder 194 95.12 Very High Very High Very High
Alzheimer's Dementia 80 90.24 High High
Tremor 2 75.68 Quite High
Injury 7 75.08 Quite High
Fasciculation 2 74.68 Quite High
Dislocations 1 73.80 Quite High
Death 28 71.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, direct interactions with acetylcholinesterase may contribute to clonidine protection from cholinesterase inhibitor toxicity.
acetylcholinesterase Binding (interactions) of associated with toxicity and clonidine
1) Confidence 0.47 Published 1986 Journal Life Sci. Section Abstract Doc Link 3784771 Disease Relevance 0.70 Pain Relevance 0.58
To confirm the mechanism of the action of the ethanol extract of Magnolia officinalis and its major ingredient, 4-O-methylhonokiol, their inhibitory activity on AChE was assessed in vivo.
AChE Binding (activity) of
2) Confidence 0.37 Published 2009 Journal J Nat Med Section Body Doc Link PMC2690856 Disease Relevance 0.21 Pain Relevance 0.04
AChE activity was calculated using the following formula:
AChE Binding (activity) of
3) Confidence 0.34 Published 2006 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1375237 Disease Relevance 0.20 Pain Relevance 0
TMT, however, was ineffective in displacing (3H)-QNB binding in vitro and did not affect (3H)-QNB binding or acetylcholinesterase activity after in vivo administration.
acetylcholinesterase Binding (binding) of
4) Confidence 0.26 Published 1982 Journal Life Sci. Section Abstract Doc Link 6890611 Disease Relevance 0.06 Pain Relevance 0.75
For BuChE, the most specific was rivastigmine; however, none of these AChEIs was absolutely specific for AChE or BuChE.
AChE Binding (specific) of
5) Confidence 0.18 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2654795 Disease Relevance 0.36 Pain Relevance 0.06
Donepezil increases acetylcholine concentration in the synaptic cleft of the hippocampus mostly through AChE inhibition (Kosasa et al 1999) and produces a dose-dependent increase in hippocampal theta rhythm amplitude elicited by stimulation of the brainstem reticular formation (Kinney et al 1999).
AChE Neg (inhibition) Binding (inhibition) of in brainstem associated with medulla and hippocampus
6) Confidence 0.18 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2654795 Disease Relevance 0 Pain Relevance 0.12
AChE activity also decreases in the CSF of patients treated with donepezil, but changes in other biomarkers, such as BuChE activity, ?
AChE Binding (activity) of
7) Confidence 0.18 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2654795 Disease Relevance 0.78 Pain Relevance 0.03
Peng et al. (1999) demonstrated that perlecan in vitro binds to acetylcholinesterase, and postulated that the perlecan-dystroglycan complex may function as an acceptor molecule for acetylcholinesterase at the neuromuscular junction. [9] Arikawa-Hirasawa et al. (2002) have shown that in perlecan-null mice, agrin and acetylcholine molecules were present at the neuromuscular junction but acetylcholinesterase was totally absent, indicating that perlecan binds acetylcholinesterase and localizes it at the synapse. [10]
acetylcholinesterase Binding (binds) of in synapse
8) Confidence 0.12 Published 2003 Journal BMC Neurol Section Body Doc Link PMC166146 Disease Relevance 0.44 Pain Relevance 0.04
The evidence is as follows; both human acetylcholinesterase (hAChE) and butyrylcholinesterase (hBuChE) are associated with senile plaques and both the pattern of hAChE oligomerisation and its enzymatic activity are altered in brain areas affected by AD [12], [13], [16], [14], [17].
acetylcholinesterase Binding (associated) of in brain associated with disease and amyloid plaque
9) Confidence 0.11 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1920558 Disease Relevance 0.82 Pain Relevance 0.12

General Comments

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