INT38594

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Context Info
Confidence 0.63
First Reported 1984
Last Reported 1994
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.44
Pain Relevance 3.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (BCAR1) cytosol (BCAR1) signal transduction (BCAR1)
cell adhesion (BCAR1) plasma membrane (BCAR1) cell division (BCAR1)
BCAR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Catecholamine 20 100.00 Very High Very High Very High
Nicotine 5 99.90 Very High Very High Very High
opiate 2 99.52 Very High Very High Very High
antagonist 1 98.96 Very High Very High Very High
Morphine 4 98.32 Very High Very High Very High
narcan 6 98.08 Very High Very High Very High
dexamethasone 6 92.68 High High
Codeine 8 89.72 High High
Enkephalin 4 88.92 High High
medulla 1 83.76 Quite High
Disease Link Frequency Relevance Heat
Hypertension 2 98.64 Very High Very High Very High
Pheochromocytoma 3 85.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There was no release of Met-enk and CAs in the medium 10 min after administration, although nicotine did cause a significant release of Met-enk and CAs.
Positive_regulation (cause) of Localization (release) of CAs associated with nicotine and catecholamine
1) Confidence 0.63 Published 1984 Journal Life Sci. Section Abstract Doc Link 6492996 Disease Relevance 0.24 Pain Relevance 0.80
Nicotine (10(-7) M to 10(-4) M) stimulated simultaneous secretion of CAs and Met-enk from the cultured human Ph cells.
Positive_regulation (stimulated) of Localization (secretion) of CAs associated with catecholamine and nicotine
2) Confidence 0.42 Published 1986 Journal Acta Endocrinol. Section Abstract Doc Link 3788413 Disease Relevance 0.19 Pain Relevance 0.71
Physiological and very high concentrations of morphine have no clear effect on CA release, while an intermediate concentration (38 ng/ml) increases the secretion of all three CAs.
Positive_regulation (increases) of Localization (secretion) of CAs associated with catecholamine and morphine
3) Confidence 0.31 Published 1994 Journal Life Sci. Section Abstract Doc Link 8107518 Disease Relevance 0 Pain Relevance 1.56

General Comments

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