INT386

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Context Info
Confidence 0.70
First Reported 1976
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 37
Total Number 45
Disease Relevance 15.92
Pain Relevance 8.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Agt) aging (Agt) extracellular region (Agt)
extracellular matrix organization (Agt)
Anatomy Link Frequency
myocytes 8
cardiac myocytes 6
brain 6
kidney 6
blood 6
Agt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
bradykinin 8 100.00 Very High Very High Very High
anesthesia 30 99.76 Very High Very High Very High
Inflammation 30 99.72 Very High Very High Very High
narcan 16 99.56 Very High Very High Very High
electroacupuncture 19 99.00 Very High Very High Very High
Morphine 14 98.92 Very High Very High Very High
agonist 4 98.74 Very High Very High Very High
Endogenous opioid 6 98.68 Very High Very High Very High
tolerance 8 98.56 Very High Very High Very High
Opioid 11 98.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypertension 755 100.00 Very High Very High Very High
Left Ventricular Hypertrophy 133 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 13 100.00 Very High Very High Very High
Insulin Resistance 19 99.96 Very High Very High Very High
Hypertrophy 45 99.90 Very High Very High Very High
Targeted Disruption 10 99.74 Very High Very High Very High
INFLAMMATION 35 99.72 Very High Very High Very High
Stress 21 99.64 Very High Very High Very High
Acid Base Imbalance 12 99.56 Very High Very High Very High
Hypoxia 109 99.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
[Accelerated angiotensinogen gene expression in the rat brain made tolerant to morphine or electroacupuncture stimulation].
Positive_regulation (Accelerated) of Gene_expression (expression) of angiotensinogen gene in brain associated with electroacupuncture and morphine
1) Confidence 0.70 Published 1989 Journal Sheng Li Xue Bao Section Title Doc Link 2781313 Disease Relevance 0 Pain Relevance 0.73
A supposition is made about the increase of angiotensin II brain synthesis under conditions of emotional stress.
Positive_regulation (increase) of Gene_expression (synthesis) of angiotensin II in brain associated with stress
2) Confidence 0.69 Published 1985 Journal Zh Vyssh Nerv Deiat Im I P Pavlova Section Abstract Doc Link 4040686 Disease Relevance 0.36 Pain Relevance 0.21
Although, the absence of the ACE2 inhibitor did not change the 125I-Ang-(1–12) level in the medium of the SHR myocytes, removal of the chymostatin inhibitor increased production of Ang I (20%) and Ang II (21%). 125I-Ang-(1–12) metabolism by SHR myocytes was significantly increased in the absence of chymostatin.
Positive_regulation (increased) of Gene_expression (production) of Ang I in myocytes associated with hypertension
3) Confidence 0.69 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3018413 Disease Relevance 0.63 Pain Relevance 0
Presumably, this can increase the amount of Ang II locally produced in the carotid body, which in turn causes an elevated level of Ang IV for the activation of intracellular signaling cascade leading to the [Ca2+]i elevation.
Positive_regulation (increase) of Gene_expression (produced) of Ang II in carotid body
4) Confidence 0.67 Published 2007 Journal The open cardiovascular medicine journal Section Body Doc Link PMC2570565 Disease Relevance 0.74 Pain Relevance 0.03
This study provides evidence that stretch-induced upregulation of osteopontin mRNA expression is mediated, in part, via production of ANG II.
Positive_regulation (mediated) of Gene_expression (production) of ANG II
5) Confidence 0.63 Published 2000 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 10807582 Disease Relevance 0.07 Pain Relevance 0
Chronic exposure to low doses of lead results in renal infiltration of immune cells, NF-kappaB activation, and overexpression of tubulointerstitial angiotensin II.
Positive_regulation (overexpression) of Gene_expression (overexpression) of angiotensin II in immune cells associated with inflammation
6) Confidence 0.53 Published 2005 Journal Antioxid. Redox Signal. Section Title Doc Link 16115032 Disease Relevance 0.33 Pain Relevance 0.20
Microinjection of ANG II into paraventricular nucleus enhances cardiac sympathetic afferent reflex in rats.
Positive_regulation (Microinjection) of Gene_expression (Microinjection) of ANG in nucleus
7) Confidence 0.50 Published 2002 Journal Am. J. Physiol. Heart Circ. Physiol. Section Title Doc Link 12003809 Disease Relevance 0 Pain Relevance 0.15
The action Ang II on arrhythmias could not be explained by the effects of Ang II on blood pressure or heart rate.
Positive_regulation (effects) of Gene_expression (effects) of Ang II in blood
8) Confidence 0.50 Published 1991 Journal Life Sci. Section Abstract Doc Link 1654493 Disease Relevance 0.28 Pain Relevance 0.53
The action Ang II on arrhythmias could not be explained by the effects of Ang II on blood pressure or heart rate.
Positive_regulation (effects) of Gene_expression (effects) of Ang II in blood
9) Confidence 0.50 Published 1991 Journal Life Sci. Section Abstract Doc Link 1654493 Disease Relevance 0.29 Pain Relevance 0.54
Angiotensin II produced increases in mean arterial pressure, and renal and mesenteric vascular resistances, but no changes in hindquarter vascular resistance.
Positive_regulation (increases) of Gene_expression (produced) of Angiotensin II
10) Confidence 0.50 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8960880 Disease Relevance 0 Pain Relevance 0.12
[Inhibiting effect of (sarcosine-1-isoleucine-8)-angiotensin II in anesthesized rats].
Positive_regulation (effect) of Gene_expression (effect) of angiotensin II associated with anesthesia
11) Confidence 0.50 Published 1987 Journal Rev. Esp. Fisiol. Section Title Doc Link 3616115 Disease Relevance 0 Pain Relevance 0.23
Although, the absence of the ACE2 inhibitor did not change the 125I-Ang-(1–12) level in the medium of the SHR myocytes, removal of the chymostatin inhibitor increased production of Ang I (20%) and Ang II (21%). 125I-Ang-(1–12) metabolism by SHR myocytes was significantly increased in the absence of chymostatin.
Positive_regulation (increased) of Gene_expression (production) of Ang II in myocytes associated with hypertension
12) Confidence 0.50 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3018413 Disease Relevance 0.64 Pain Relevance 0
Combined injection of CCK-8 and Ang II in a ratio of 1 ng: 2.5 microg or 1 ng: 5 microg produced significantly greater effect in antagonizing MIA.
Positive_regulation (injection) of Gene_expression (injection) of Ang II associated with analgesia
13) Confidence 0.50 Published 2000 Journal Pain Section Abstract Doc Link 10781920 Disease Relevance 0 Pain Relevance 0.97
Angiotensin IV, a hexapeptide fragment (3-8) of angiotensin II metabolism, has been reported to produce vasodilatation within the renal vasculature by activation of the putative AT4 receptor.
Positive_regulation (activation) of Gene_expression (produce) of Angiotensin IV in vasculature associated with increased venous pressure under development
14) Confidence 0.49 Published 1999 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 10445671 Disease Relevance 0.10 Pain Relevance 0
Li et al.24 have suggested that the LVH in SHR was associated with ACE and ACE2 gene expression cardiac RAS, while aortic hypertrophy was associated with angiotensinogen and ACE2 gene expression of aortic RAS.
Positive_regulation (associated) of Gene_expression (expression) of angiotensinogen associated with hypertrophy, left ventricular hypertrophy and hypertension
15) Confidence 0.49 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC3020347 Disease Relevance 0.77 Pain Relevance 0
Hence, we found an increased intensity of staining of the Ang IV-binding sites and AT4 receptors in the CH when comparing with that of the Nx carotid bodies.
Positive_regulation (increased) of Gene_expression (sites) of Ang IV-binding associated with hypoxia
16) Confidence 0.48 Published 2007 Journal The open cardiovascular medicine journal Section Body Doc Link PMC2570565 Disease Relevance 0.43 Pain Relevance 0.06
In transgenic animals the overexpression of the angiotensinogen gene in the cardiac myocytes resulted in increased cardiac Ang II concentration and right and left ventricular hypertrophy, unaccompanied by either hypertension or increased circulating levels of Ang II.29 These data strongly suggest that Ang II may induce cardiac hypertrophy regardless of its hemodynamic effects.
Positive_regulation (overexpression) of Gene_expression (overexpression) of angiotensinogen gene in cardiac myocytes associated with targeted disruption, left ventricular hypertrophy, hypertension and coronary heart disease
17) Confidence 0.48 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC3020347 Disease Relevance 0.75 Pain Relevance 0
In transgenic animals the overexpression of the angiotensinogen gene in the cardiac myocytes resulted in increased cardiac Ang II concentration and right and left ventricular hypertrophy, unaccompanied by either hypertension or increased circulating levels of Ang II.29 These data strongly suggest that Ang II may induce cardiac hypertrophy regardless of its hemodynamic effects.
Positive_regulation (increased) of Gene_expression (overexpression) of angiotensinogen gene in cardiac myocytes associated with targeted disruption, left ventricular hypertrophy, hypertension and coronary heart disease
18) Confidence 0.48 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC3020347 Disease Relevance 0.84 Pain Relevance 0
On the other hand, Shan et al.28 have observed an increase in the Ang II levels in the cardiac and kidney tissues of rats submitted to chronic SAD, and these Ang II levels were more elevated when these animals were submitted to chronic stress, suggesting that elevated BPV and Ang II liberation may be related to end?
Positive_regulation (elevated) of Gene_expression (levels) of Ang II in kidney associated with stress
19) Confidence 0.48 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC3020347 Disease Relevance 0.69 Pain Relevance 0
On the other hand, Shan et al.28 have observed an increase in the Ang II levels in the cardiac and kidney tissues of rats submitted to chronic SAD, and these Ang II levels were more elevated when these animals were submitted to chronic stress, suggesting that elevated BPV and Ang II liberation may be related to end?
Positive_regulation (elevated) of Gene_expression (liberation) of Ang II in kidney associated with stress
20) Confidence 0.48 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC3020347 Disease Relevance 0.70 Pain Relevance 0

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