INT38632

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Context Info
Confidence 0.50
First Reported 1986
Last Reported 1997
Negated 0
Speculated 1
Reported most in Abstract
Documents 2
Total Number 4
Disease Relevance 0.46
Pain Relevance 2.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Odc1) lyase activity (Odc1)
Odc1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Somatostatin 3 99.32 Very High Very High Very High
Morphine 20 99.26 Very High Very High Very High
Neuropeptide 1 97.40 Very High Very High Very High
Enkephalin 6 97.08 Very High Very High Very High
opioid receptor 2 96.68 Very High Very High Very High
narcan 2 90.48 High High
Deafferentation 1 90.48 High High
opiate 8 84.68 Quite High
Hippocampus 1 75.00 Quite High
Opioid 1 52.88 Quite High
Disease Link Frequency Relevance Heat
Convulsion 6 100.00 Very High Very High Very High
Epilepsy 1 50.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results are consistent with the hypothesis that the early induction of ODC following the initiation of seizures leads to an alteration in genomic expression, which, in turn, changes neuropeptide levels.
Positive_regulation (leads) of Positive_regulation (induction) of ODC associated with convulsion and neuropeptide
1) Confidence 0.50 Published 1986 Journal J. Neurosci. Section Abstract Doc Link 3794781 Disease Relevance 0.46 Pain Relevance 0.49
Finally, as was the case for insulin induced stimulation of ornithine decarboxylase activity, i.c.v. injection of morphine markedly diminished insulin induced stimulation of hepatic ornithine decarboxylase mRNA accumulation.
Positive_regulation (induced) of Positive_regulation (stimulation) of ornithine decarboxylase associated with morphine
2) Confidence 0.47 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9274973 Disease Relevance 0 Pain Relevance 1.06
The induction of ODC is not mediated by gastrin; ODC activation appears to be related to acid inhibition per se or to mucosal maintenance and repair; somatostatin, or rather the lack of it, might contribute to the induction of ODC after acid blockade.
Spec (might) Positive_regulation (contribute) of Spec (might) Positive_regulation (induction) of ODC associated with somatostatin
3) Confidence 0.46 Published 1996 Journal Am. J. Physiol. Section Abstract Doc Link 8638714 Disease Relevance 0 Pain Relevance 0.10
Finally, as was the case for insulin induced stimulation of ornithine decarboxylase activity, i.c.v. injection of morphine markedly diminished insulin induced stimulation of hepatic ornithine decarboxylase mRNA accumulation.
Positive_regulation (stimulation) of Positive_regulation (accumulation) of ornithine decarboxylase associated with morphine
4) Confidence 0.29 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9274973 Disease Relevance 0 Pain Relevance 1.05

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