INT38644

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Context Info
Confidence 0.53
First Reported 1986
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 30
Total Number 31
Disease Relevance 12.48
Pain Relevance 6.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (DST) endoplasmic reticulum (DST) cytoplasm (DST)
cell adhesion (DST) cell motility (DST) nucleus (DST)
Anatomy Link Frequency
spinal cord 2
lamina terminalis 1
PAG 1
intestine 1
DMH 1
DST (Homo sapiens)
Pain Link Frequency Relevance Heat
Raphe magnus 8 100.00 Very High Very High Very High
lidocaine 6 99.76 Very High Very High Very High
Spinal cord 190 99.68 Very High Very High Very High
allodynia 40 99.46 Very High Very High Very High
narcan 10 99.40 Very High Very High Very High
cINOD 5 98.88 Very High Very High Very High
Cholecystokinin 104 98.30 Very High Very High Very High
Morphine 4 98.28 Very High Very High Very High
Neuropathic pain 100 94.68 High High
gABA 10 90.48 High High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 33 100.00 Very High Very High Very High
Urological Neuroanatomy 13 100.00 Very High Very High Very High
Gliosis 10 99.60 Very High Very High Very High
Neuropathic Pain 170 99.46 Very High Very High Very High
Hypoglycemia 42 99.38 Very High Very High Very High
Cardiovascular Disease 50 99.20 Very High Very High Very High
Stress 211 96.56 Very High Very High Very High
Myocardial Infarction 20 96.12 Very High Very High Very High
Injury 70 95.24 Very High Very High Very High
Targeted Disruption 82 93.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, we evaluated the role of normal DMH activation in the counterregulatory response to a single bout of IIH.
Positive_regulation (activation) of DMH associated with hypoglycemia
1) Confidence 0.53 Published 2004 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 14660476 Disease Relevance 0.52 Pain Relevance 0.09
Our finding suggests that DMH inactivation may play a specific role in decreasing the HPA axis response after repeated bouts of IIH.
Positive_regulation (inactivation) of DMH associated with hypoglycemia
2) Confidence 0.39 Published 2004 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 14660476 Disease Relevance 0.51 Pain Relevance 0.08
HMG CoA reductase activity decreased in the high fat and most of the tissues of the kernal + DMH, kernal + chilli and kernal + chilli + DMH groups, while it increased in the DMH, chilli and chilli + DMH groups.
Positive_regulation (increased) of DMH in fat
3) Confidence 0.38 Published 1997 Journal Indian J. Exp. Biol. Section Abstract Doc Link 9475077 Disease Relevance 0.15 Pain Relevance 0
Per standard deviation increases in BPA concentration were associated with positive responses to questions about physician diagnoses of myocardial infarction in age, sex and ethnicity adjusted models in 2005/06 (OR?
Positive_regulation (increases) of BPA associated with myocardial infarction
4) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2800195 Disease Relevance 0.32 Pain Relevance 0.08
Higher BPA concentrations in NHANES respondents were found to be associated with cardiovascular disease diagnoses (Odds Ratio (OR) per 1 standard deviation (SD) increase in BPA concentration?
Positive_regulation (increase) of BPA associated with cardiovascular disease
5) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2800195 Disease Relevance 0.43 Pain Relevance 0
The cross sectional nature of the associations reported need to be treated with caution, as it is theoretically possible, for example, that those with cardiovascular disease change their diets in such a way as to increase BPA exposure.
Positive_regulation (increase) of BPA associated with cardiovascular disease
6) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2800195 Disease Relevance 0.63 Pain Relevance 0
Because DMH activation has been implicated in the sympathoadrenal and hypothalamic-pituitary-adrenal (HPA) responses to stressors, we hypothesized that its blunted activation may play a role in the impaired counterregulatory response that is also observed with repeated bouts of IIH.
Positive_regulation (activation) of DMH in pituitary associated with hypoglycemia
7) Confidence 0.36 Published 2004 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 14660476 Disease Relevance 0.49 Pain Relevance 0.07
Inactivation of the DMH selectively inhibits the ACTH and corticosterone responses to hypoglycemia.
Positive_regulation (Inactivation) of DMH associated with hypoglycemia
8) Confidence 0.34 Published 2004 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Title Doc Link 14660476 Disease Relevance 0.50 Pain Relevance 0.07
We have previously reported that repeated bouts of insulin-induced hypoglycemia (IIH) in the rat result in blunted activation of the paraventricular, arcuate, and dorsomedial hypothalamic (DMH) nuclei.
Positive_regulation (activation) of DMH associated with hypoglycemia
9) Confidence 0.31 Published 2004 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 14660476 Disease Relevance 0.48 Pain Relevance 0.06
Local infusion of lidocaine (n = 8) to inactivate the DMH during a 2-h bout of IIH resulted in a significant overall decrease of the ACTH response and a delay of onset of the corticosterone response compared with vehicle-infused controls (n = 9).
Positive_regulation (inactivate) of DMH associated with hypoglycemia and lidocaine
10) Confidence 0.31 Published 2004 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 14660476 Disease Relevance 0.52 Pain Relevance 0.10
For studies using the DST, we only included those that utilized a standard DST methodology.
Positive_regulation (utilized) of DST
11) Confidence 0.22 Published 2010 Journal Journal of Psychopharmacology (Oxford, England) Section Body Doc Link PMC2951595 Disease Relevance 0.86 Pain Relevance 0
This increase in DST non-suppressors after 1 year was partially explained by clinical deterioration and non-compliance in some patients.
Positive_regulation (increase) of DST
12) Confidence 0.22 Published 2010 Journal Journal of Psychopharmacology (Oxford, England) Section Body Doc Link PMC2951595 Disease Relevance 0.31 Pain Relevance 0
At the end of 6 weeks of treatment, the results indicated a significant alteration in the antioxidative defense status of the intestine in the presence of the procarcinogen DMH, which was restored with the administration of NSAIDs.
Positive_regulation (restored) of DMH in intestine associated with cinod
13) Confidence 0.14 Published 2008 Journal Int. J. Toxicol. Section Abstract Doc Link 18404540 Disease Relevance 0.44 Pain Relevance 0.42
Because rats with DMH or PVH lesions respond normally to thermal stimulation (cold or warmth) and to pharmacological stimulation of either a cold (TRPM8) or a warmth (TRPV1) receptor, both DMH and PVH are likely uninvolved in the thermoafferent pathway.
Positive_regulation (stimulation) of DMH associated with increased venous pressure under development
14) Confidence 0.13 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762328 Disease Relevance 0.73 Pain Relevance 0.11
Conditioning stimulation of NRM, NRPG, PAG, CP, SCT and DMH strongly inhibited component 2.
Positive_regulation (stimulation) of DMH in SCT associated with raphe magnus and urological neuroanatomy
15) Confidence 0.08 Published 1986 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 3795618 Disease Relevance 0.27 Pain Relevance 0.61
The circumventricular organs, organum vasculosum lamina terminalis (OVLT) and subfornical organ (SFO), are potential sites that could detect increases in plasma lactate levels and activate the DMH.
Positive_regulation (activate) of DMH in lamina terminalis
16) Confidence 0.04 Published 1997 Journal J. Neurosci. Section Abstract Doc Link 9391025 Disease Relevance 0.24 Pain Relevance 0.19
Serum IGF-II levels were independent of DMH-application.
Neg (independent) Positive_regulation (independent) of DMH
17) Confidence 0.04 Published 2006 Journal J Carcinog Section Body Doc Link PMC1660565 Disease Relevance 1.28 Pain Relevance 0
In mc4r ko mice, or lethal yellow mice overexpressing agouti, NPY expression (but not galanin or POMC) is significantly elevated in the DMH.
Positive_regulation (elevated) of DMH
18) Confidence 0.04 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.07 Pain Relevance 0.08
Moreover, the upregulation of CATX protein was accompanied by a substantial increase in activity.
Positive_regulation (upregulation) of CATX protein
19) Confidence 0.04 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2527007 Disease Relevance 0.41 Pain Relevance 0.46
Our results clearly show that immediately after surgery, concurrent to the onset of mechanical allodynia, both proteases, CATS and CATX, are upregulated in the spinal cord.
Positive_regulation (upregulated) of CATX in spinal cord associated with allodynia and spinal cord
20) Confidence 0.04 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2527007 Disease Relevance 0.41 Pain Relevance 0.46

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