INT38650

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Context Info
Confidence 0.50
First Reported 1982
Last Reported 1986
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0
Pain Relevance 1.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasmic membrane-bounded vesicle (Dbh) cytoplasm (Dbh)
Anatomy Link Frequency
striatum 3
heart 2
zona incerta 1
Dbh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 17 100.00 Very High Very High Very High
monoamine 2 99.54 Very High Very High Very High
Clonidine 5 93.48 High High
noradrenaline 6 75.00 Quite High
Catecholamine 2 75.00 Quite High
agonist 1 56.28 Quite High
Desipramine 2 45.68 Quite Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dopamine accumulation after dopamine beta-hydroxylase inhibition in rat heart as an index of norepinephrine turnover.
Positive_regulation (accumulation) of Negative_regulation (inhibition) of dopamine beta-hydroxylase in heart associated with dopamine
1) Confidence 0.50 Published 1982 Journal Life Sci. Section Title Doc Link 6290819 Disease Relevance 0 Pain Relevance 0.57
This peak was mainly due to 3,4-dihydroxyphenylacetic acid synthesized by noradrenergic terminals since: it appeared at the same oxidation potential as 3,4-dihydroxyphenylacetic acid in vitro; it was rapidly suppressed after inhibition of tyrosine hydroxylase by alpha-methyl-p-tyrosine or monoamine oxidase by pargyline; blockade of dopamine-beta-hydroxylase by FLA 63 induced a marked increase in this signal, whereas this drug was without effect in dopaminergic terminals fields (striatum, zona incerta); stimulation of alpha 2 noradrenergic receptors by clonidine (50 micrograms/kg) decreased the peak height and this effect was reversed by piperoxane (30 mg/kg).
Positive_regulation (increase) of Negative_regulation (blockade) of dopamine-beta-hydroxylase in striatum associated with dopamine, clonidine and monoamine
2) Confidence 0.36 Published 1986 Journal Neuroscience Section Abstract Doc Link 3796818 Disease Relevance 0 Pain Relevance 0.30
This peak was mainly due to 3,4-dihydroxyphenylacetic acid synthesized by noradrenergic terminals since: it appeared at the same oxidation potential as 3,4-dihydroxyphenylacetic acid in vitro; it was rapidly suppressed after inhibition of tyrosine hydroxylase by alpha-methyl-p-tyrosine or monoamine oxidase by pargyline; blockade of dopamine-beta-hydroxylase by FLA 63 induced a marked increase in this signal, whereas this drug was without effect in dopaminergic terminals fields (striatum, zona incerta); stimulation of alpha 2 noradrenergic receptors by clonidine (50 micrograms/kg) decreased the peak height and this effect was reversed by piperoxane (30 mg/kg).
Positive_regulation (increase) of in zona incerta Negative_regulation (blockade) of dopamine-beta-hydroxylase in striatum associated with dopamine, clonidine and monoamine
3) Confidence 0.12 Published 1986 Journal Neuroscience Section Abstract Doc Link 3796818 Disease Relevance 0 Pain Relevance 0.30

General Comments

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