INT3866

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Context Info
Confidence 0.59
First Reported 1977
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 30
Total Number 30
Disease Relevance 21.58
Pain Relevance 1.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (INS) small molecule metabolic process (INS) extracellular region (INS)
carbohydrate metabolic process (INS) cell-cell signaling (INS)
Anatomy Link Frequency
blood 6
plasma 4
muscle cells 2
follicle 2
INS (Homo sapiens)
Pain Link Frequency Relevance Heat
Eae 12 100.00 Very High Very High Very High
c fibre 1 99.32 Very High Very High Very High
Paracetamol 2 99.20 Very High Very High Very High
unmyelinated 1 99.14 Very High Very High Very High
tolerance 62 97.40 Very High Very High Very High
Inflammation 215 96.84 Very High Very High Very High
Angina 9 94.48 High High
cva 27 94.16 High High
addiction 6 87.16 High High
headache 7 86.20 High High
Disease Link Frequency Relevance Heat
Insulin Resistance 342 100.00 Very High Very High Very High
Stress 248 100.00 Very High Very High Very High
Hyperinsulinism 76 100.00 Very High Very High Very High
Hyperglycemia 51 100.00 Very High Very High Very High
Abdominal Obesity 15 100.00 Very High Very High Very High
Ketosis 1 100.00 Very High Very High Very High
Diabetes Mellitus 1059 99.78 Very High Very High Very High
Infection 30 99.68 Very High Very High Very High
Schizophrenia 167 99.62 Very High Very High Very High
Prediabetic State 37 99.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this way, hepatic glucose production and subsequent increased insulin requirement are reduced.
Positive_regulation (increased) of Positive_regulation (requirement) of insulin associated with hyperinsulinism
1) Confidence 0.59 Published 2010 Journal Indian Journal of Pharmaceutical Sciences Section Body Doc Link PMC2883206 Disease Relevance 0.77 Pain Relevance 0.03
Fructose infusion increased insulin requirements 2.3-fold to maintain blood glucose.
Positive_regulation (increased) of Positive_regulation (requirements) of insulin in blood associated with hyperinsulinism
2) Confidence 0.49 Published 2000 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 11001775 Disease Relevance 0.10 Pain Relevance 0.10
One fourth of those observed became overtreated during periods of emotional turmoil when need for increased insulin to counter stress-induced hyperglycemia and ketosis led to chronic increase in dosage.
Positive_regulation (increase) of Positive_regulation (increased) of insulin associated with hyperglycemia, stress, ketosis and hyperinsulinism
3) Confidence 0.48 Published 1977 Journal Am. J. Dis. Child. Section Abstract Doc Link 888803 Disease Relevance 1.14 Pain Relevance 0.09
The authors concluded that for patients who experience late afternoon increases in blood glucose levels, twice-daily insulin glargine is a suitable alternative which does not require an increase in insulin dosage nor does it negatively impact treatment satisfaction.


Neg (not) Positive_regulation (require) of Positive_regulation (increase) of insulin in blood
4) Confidence 0.47 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012430 Disease Relevance 0.28 Pain Relevance 0
For this hypothesis to work it is necessary that the tissues respond to the increased levels of insulin by increased uptake of glucose.
Positive_regulation (levels) of Positive_regulation (increased) of insulin
5) Confidence 0.46 Published 2007 Journal BMC Evol Biol Section Body Doc Link PMC1868084 Disease Relevance 0.61 Pain Relevance 0
For this hypothesis to work it is necessary that the tissues respond to the increased levels of insulin by increased uptake of glucose.
Positive_regulation (increased) of Positive_regulation (levels) of insulin
6) Confidence 0.46 Published 2007 Journal BMC Evol Biol Section Body Doc Link PMC1868084 Disease Relevance 0.61 Pain Relevance 0
The results revealed that the warm and cold perception thresholds, reflecting the functional states of unmyelinated C-fibres and A-delta fibres respectively, increased with reduced insulin sensitivity and with increased fasting insulin concentrations.
Positive_regulation (increased) of Positive_regulation (increased) of insulin associated with c fibre and unmyelinated
7) Confidence 0.44 Published 1994 Journal Clin Exp Neurol Section Abstract Doc Link 7586662 Disease Relevance 0.46 Pain Relevance 0.19
The accumulation of misfolded mutant proinsulin in the ER leads to activation of the unfolded protein response (UPR) including expression of the pro-apoptotic CHOP gene.
Positive_regulation (leads) of Positive_regulation (accumulation) of proinsulin associated with apoptosis
8) Confidence 0.43 Published 2010 Journal Rev Endocr Metab Disord Section Body Doc Link PMC2974937 Disease Relevance 1.02 Pain Relevance 0.04
The increase in blood glucose in group T during weaning was accompanied by an increase in blood insulin, which remained elevated after extubation, while the blood glucose decreased.
Positive_regulation (elevated) of Positive_regulation (increase) of insulin in blood
9) Confidence 0.41 Published 2004 Journal Crit Care Section Body Doc Link PMC420062 Disease Relevance 0.60 Pain Relevance 0
We hypothesize that the upregulation of the insulin signaling pathway at the gene expression level observed in the relatives could be an effective compensation for otherwise reduced insulin signaling activity.
Positive_regulation (compensation) of Positive_regulation (upregulation) of insulin
10) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719801 Disease Relevance 0.88 Pain Relevance 0
Acute insulin response (AIR) is the increment in the plasma insulin concentration above baseline in the first 8 minutes after glucose administration and is used as a sensitive measure of ?
Positive_regulation (increment) of Positive_regulation (response) of insulin in plasma associated with hyperinsulinism
11) Confidence 0.35 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2872762 Disease Relevance 0.39 Pain Relevance 0.04
Collectively, these studies have found that ADT leads to an increase in fat mass, an increase in plasma insulin, decreased insulin sensitivity (48), increased levels of glycosylated haemoglobin, an increase in plasma cholesterol, LDL-cholesterol and triglycerides but also an increase in plasma HDL-cholesterol, which contrasts with the low HDL-cholesterol levels found in the metabolic syndrome.
Positive_regulation (increase) of Positive_regulation (increase) of insulin in plasma associated with metabolic syndrome and disorder of lipid metabolism
12) Confidence 0.35 Published 2008 Journal International Journal of Clinical Practice Section Body Doc Link PMC2327081 Disease Relevance 1.20 Pain Relevance 0.06
Epicatechin, its active principle, has been found to be insulinogenic, enhancing insulin release and conversion of proinsulin to insulin in vitro.
Positive_regulation (enhancing) of Positive_regulation (conversion) of proinsulin
13) Confidence 0.32 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2275761 Disease Relevance 0.39 Pain Relevance 0
Epicatechin, its active principle, has been found to be insulinogenic, enhancing insulin release and conversion of proinsulin to insulin in vitro.
Positive_regulation (enhancing) of Positive_regulation (conversion) of insulin
14) Confidence 0.32 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2275761 Disease Relevance 0.39 Pain Relevance 0
Rosiglitazone led to significantly increased insulin sensitivity (glucose infusion rate during the clamp: from 46 ± 9.5 to 67.4 ± 9.2 ?
Positive_regulation (led) of Positive_regulation (increased) of insulin associated with hyperinsulinism
15) Confidence 0.32 Published 2010 Journal Diabetes Section Body Doc Link PMC2797922 Disease Relevance 0.35 Pain Relevance 0
Ye et al., were able to demonstrate that amylin infusion (5 nmol/h for 4 h) conscious rats that fasted for 5–7 hours resulted in an elevation of insulin, lactate and glucose (P < 0.05 vs. control).
Positive_regulation (resulted) of Positive_regulation (elevation) of insulin
16) Confidence 0.25 Published 2002 Journal Cardiovasc Diabetol Section Body Doc Link PMC140143 Disease Relevance 0.87 Pain Relevance 0.11
Persons who are unable to compensate for increased insulin demand can develop prediabetes states, such as impaired glucose tolerance (IGT) and impaired fasting glucose (IFG), which can then progress to type 2 diabetes.
Neg (unable) Positive_regulation (compensate) of Neg (unable) Positive_regulation (increased) of insulin associated with diabetes mellitus, prediabetic state, tolerance, hyperinsulinism and impaired glucose tolerance
17) Confidence 0.21 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2878957 Disease Relevance 1.20 Pain Relevance 0.13
For example, Zawadzki and associates [10] reported that adding PRO to a post-exercise CHO supplement promoted a greater increase in insulin levels and glycogen restoration.
Positive_regulation (promoted) of Positive_regulation (increase) of insulin
18) Confidence 0.20 Published 2007 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2206056 Disease Relevance 0 Pain Relevance 0
We recruited 20 consecutive acute myocardial infarction patients with a history of type 2 diabetes, who self-reported taking insulin or oral hypoglycemic drugs on a regular basis (the DM group) and 20 patients with a negative history of diabetes, who had a serum glucose level of ?
Positive_regulation (reported) of Positive_regulation (taking) of insulin associated with diabetes mellitus and myocardial infarction
19) Confidence 0.18 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2494657 Disease Relevance 1.43 Pain Relevance 0.20
Recent data suggests that a defect in insulin activation of glucose transportation in muscle cells could be induced by serine kinase cascade activation, which is down stream mediators of tissue inflammation factors [67].
Positive_regulation (induced) of Positive_regulation (activation) of insulin in muscle cells associated with inflammation
20) Confidence 0.15 Published 2005 Journal Immun Ageing Section Body Doc Link PMC1166571 Disease Relevance 1.82 Pain Relevance 0.30

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