INT38671

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Context Info
Confidence 0.53
First Reported 1986
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 62
Total Number 63
Disease Relevance 40.17
Pain Relevance 5.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (KRT20) cytoplasm (KRT20)
Anatomy Link Frequency
B cells 6
plasma 2
liver 2
colon 2
myocardium 1
KRT20 (Homo sapiens)
Pain Link Frequency Relevance Heat
sodium channel 164 100.00 Very High Very High Very High
Inflammation 155 100.00 Very High Very High Very High
antagonist 36 100.00 Very High Very High Very High
Nav1.7 26 100.00 Very High Very High Very High
methotrexate 5 99.28 Very High Very High Very High
rheumatoid arthritis 72 98.60 Very High Very High Very High
spinal inflammation 41 97.96 Very High Very High Very High
pain flank 1 97.40 Very High Very High Very High
Arthritis 96 97.20 Very High Very High Very High
potassium channel 29 97.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 740 100.00 Very High Very High Very High
INFLAMMATION 178 100.00 Very High Very High Very High
Injury 146 100.00 Very High Very High Very High
Necrosis 28 100.00 Very High Very High Very High
Colon Cancer 64 99.98 Very High Very High Very High
Endometrial Cancer 477 99.88 Very High Very High Very High
Precursor Cell Lymphoblastic Leukemia-lymphoma 12 99.84 Very High Very High Very High
Systemic Lupus Erythematosus 190 99.72 Very High Very High Very High
Carcinoma 233 99.64 Very High Very High Very High
Pancreatic Cancer 28 99.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunohistochemical staining revealed that the tumor cells were positive for CD21, CD23, CD35, and clusterin, and focally positive for CD68, CD20, and CD79a.
Positive_regulation (positive) of CD20 associated with cancer
1) Confidence 0.53 Published 2006 Journal Arch. Pathol. Lab. Med. Section Abstract Doc Link 17076538 Disease Relevance 0.50 Pain Relevance 0.13
We studied functional protein C activity, both anticoagulant and amidolytic, as well as protein C antigen in 30 normal subjects, several members of a family with congenital protein C deficiency, 18 patients with severe preeclampsia, 27 patients with coronary heart disease, including 15 patients with myocardial infarction and 12 with angina pectoris, 20 patients on stable oral anticoagulant therapy (thrombotest values: 3-12%) and three patients with disseminated intravascular coagulation.
Positive_regulation (studied) of protein in heart associated with angina, coronary artery disease, thrombosis, myocardial infarction and pre-eclampsia
2) Confidence 0.49 Published 1986 Journal Thromb. Res. Section Abstract Doc Link 3798419 Disease Relevance 0.46 Pain Relevance 0.09
The ileocecal lesion was diagnosed as a recurrence because of the histological findings, which included mucosal preservation, a similarity with the histologic type of stomach carcinoma, and atypical immunoreactivity for primary colon carcinoma; the lesion was negative for both cytokeratin 7 and cytokeratin 20.
Positive_regulation (negative) of cytokeratin 20 in colon associated with colon cancer, stomach cancer and recurrence
3) Confidence 0.49 Published 2004 Journal Acta Med. Okayama Section Abstract Doc Link 15551760 Disease Relevance 0.94 Pain Relevance 0.16
Stainings for mucin and for CK7 were positive, while staining for CK20 was negative.
Positive_regulation (negative) of CK20
4) Confidence 0.47 Published 2006 Journal Skinmed Section Abstract Doc Link 16957443 Disease Relevance 0.82 Pain Relevance 0.21
Immunohistochemical staining was positive for carcinoembryonic antigen, and negative for cytokeratin (CK)7 and CK20.
Positive_regulation (negative) of CK20
5) Confidence 0.47 Published 2006 Journal Skinmed Section Abstract Doc Link 16957443 Disease Relevance 0.80 Pain Relevance 0.16
In contrast, colon cancers underexpressed CK 20 mRNA by comparison with the respective controls.
Positive_regulation (underexpressed) of CK 20 mRNA in colon associated with colon cancer
6) Confidence 0.46 Published 1999 Journal Clin. Cancer Res. Section Abstract Doc Link 10537351 Disease Relevance 1.28 Pain Relevance 0.08
On immunohistochemistry they were found to be positive for Bcl2, CD20, CD45RB and CD79a, but negative for CD3, CD5, CD10 and cyclin D1.
Positive_regulation (positive) of CD20
7) Confidence 0.45 Published 2008 Journal Pathol. Int. Section Abstract Doc Link 18324920 Disease Relevance 0.58 Pain Relevance 0.24
Rituximab targets the CD20 molecule, which is selectively expressed on B cells and depletes these cells [26].
Positive_regulation (targets) of CD20 in B cells
8) Confidence 0.45 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833979 Disease Relevance 1.03 Pain Relevance 0.38
The benign gastric epithelium were negative for both CK7 and CK20 (figure 2C), while the malignant colonic epithelium was positive for CK20 (figure 2C) and negative for CK7 supporting the dual population of cells in the gastric mucosal biopsies.


Positive_regulation (negative) of CK20 in gastric epithelium associated with malignant neoplastic disease
9) Confidence 0.43 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2734526 Disease Relevance 0.91 Pain Relevance 0
They were negative for CD45 and CD20.
Positive_regulation (negative) of CD20
10) Confidence 0.41 Published 2001 Journal Am. J. Hematol. Section Abstract Doc Link 11426491 Disease Relevance 0.98 Pain Relevance 0.09
A subgroup of the pancreatic cancers exhibited a 3.2-fold increase in CK 20 mRNA by comparison with respective normal controls.
Positive_regulation (increase) of CK 20 mRNA associated with pancreatic cancer
11) Confidence 0.41 Published 1999 Journal Clin. Cancer Res. Section Abstract Doc Link 10537351 Disease Relevance 1.28 Pain Relevance 0.07
All endometrial carcinomas with transitional cell differentiation are negative for cytokeratin 20 (CK20), but half are positive for cytokeratin 7 (CK7) [3].
Positive_regulation (negative) of CK20 associated with endometrial cancer
12) Confidence 0.38 Published 2007 Journal Diagn Pathol Section Body Doc Link PMC1947947 Disease Relevance 1.00 Pain Relevance 0
All endometrial carcinomas with transitional cell differentiation are negative for cytokeratin 20 (CK20), but half are positive for cytokeratin 7 (CK7) [3].
Positive_regulation (negative) of cytokeratin 20 associated with endometrial cancer
13) Confidence 0.38 Published 2007 Journal Diagn Pathol Section Body Doc Link PMC1947947 Disease Relevance 1.00 Pain Relevance 0
The surgically resected tumor specimen showed proliferation of lymphoid cells with lymphoepithelial lesions, which were positive for CD20 and kappa light chain.
Positive_regulation (positive) of CD20 associated with cancer
14) Confidence 0.30 Published 2002 Journal Intern. Med. Section Abstract Doc Link 11993793 Disease Relevance 1.13 Pain Relevance 0.09
Within the gastrointestinal and urothelial epithelial tissues, K20 is absent from the stem cell compartment and appears to be switched on during terminal differentiation and thus is most prominent in small intestinal villus-lining and large intestinal surface-lining epithelia (Fig. 3b) and in urothelial umbrella cells.
Positive_regulation (switched) of K20 in intestinal villus
15) Confidence 0.27 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.28 Pain Relevance 0
Recent studies demonstrate that an increase in urinary calcium excretion is mainly associated with a high consumption of sodium and animal protein rather than consumption of dietary calcium [17,31].
Positive_regulation (consumption) of animal protein
16) Confidence 0.24 Published 2006 Journal Nutr J Section Body Doc Link PMC1586208 Disease Relevance 0.50 Pain Relevance 0
Immune status is a major concern in patients treated with rituximab being the induction of low CD20+ counts and hypogammaglobulinemia (specifically low levels of immunoglobulin M), two previously reported secondary effects.
Positive_regulation (induction) of CD20 associated with agammaglobulinemia
17) Confidence 0.22 Published 2007 Journal Ann Hematol Section Body Doc Link PMC2040174 Disease Relevance 0.71 Pain Relevance 0
Chronic lymphocytic leukemia (CLL) is characterized by the gradual accumulation of small mature B-cells, non proliferating cells and B-cell surface markers such as CD19, CD20 in addition to CD5 [32] in the patient.
Positive_regulation (accumulation) of CD20 in B-cell associated with chronic lymphoid leukemia
18) Confidence 0.16 Published 2010 Journal Silenc Section Body Doc Link PMC2835996 Disease Relevance 1.73 Pain Relevance 0
Furthermore, residual RTX remains in patientsÂ’ serum for three to six months after treatment and could potentially block CD20 binding sites.46 Preclinical studies using human lymphoma cell lines, patient-derived specimens, and mouse xenograft models have shown that prior RTX therapy reduces CD20 binding, tumor-specific localization, and tumor control for 131I-TST.46 Despite this preclinical data, 131I-TST has been shown to be clinically effective in RTX-refractory relapsed low grade B-cell NHL as discussed previously.31 Future clinical studies should help determine whether inclusion of RTX in induction chemotherapy regimens abrogates the incremental therapeutic gain of consolidation 131I-TST found in the studies listed in Table 4.


Positive_regulation (reduces) of CD20 in B-cell associated with lymphatic system cancer and cancer
19) Confidence 0.16 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886324 Disease Relevance 0.82 Pain Relevance 0
SLE patients showed increased frequencies of CD27++/CD20?
Positive_regulation (frequencies) of CD20 associated with systemic lupus erythematosus
20) Confidence 0.15 Published 2007 Journal J Clin Immunol Section Body Doc Link PMC2039801 Disease Relevance 0.48 Pain Relevance 0

General Comments

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