INT38673

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Context Info
Confidence 0.42
First Reported 1986
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 38
Total Number 39
Disease Relevance 22.49
Pain Relevance 2.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (KRT20) cytoplasm (KRT20)
Anatomy Link Frequency
B cells 6
lymphocytes 2
macrophages 1
blood 1
monocytes 1
KRT20 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 162 95.28 Very High Very High Very High
Angina 18 94.32 High High
chemokine 29 93.04 High High
antagonist 54 91.04 High High
medulla 8 89.88 High High
adenocard 4 89.36 High High
Inflammation 280 88.96 High High
cytokine 138 85.44 High High
headache 14 85.40 High High
vincristine 3 84.24 Quite High
Disease Link Frequency Relevance Heat
Colorectal Cancer 41 99.96 Very High Very High Very High
Anaplastic Large Cell Lymphoma 41 99.56 Very High Very High Very High
Malignant Neoplastic Disease 58 99.52 Very High Very High Very High
Systemic Lupus Erythematosus 494 99.32 Very High Very High Very High
Pre-eclampsia 1 98.96 Very High Very High Very High
Herpes Simplex Encephalitis 3 98.76 Very High Very High Very High
T-cell Lymphoma 42 98.46 Very High Very High Very High
Coronary Artery Disease 17 97.72 Very High Very High Very High
Breast Cancer 41 97.64 Very High Very High Very High
Cancer 517 97.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We studied functional protein C activity, both anticoagulant and amidolytic, as well as protein C antigen in 30 normal subjects, several members of a family with congenital protein C deficiency, 18 patients with severe preeclampsia, 27 patients with coronary heart disease, including 15 patients with myocardial infarction and 12 with angina pectoris, 20 patients on stable oral anticoagulant therapy (thrombotest values: 3-12%) and three patients with disseminated intravascular coagulation.
Negative_regulation (deficiency) of protein in heart associated with angina, coronary artery disease, thrombosis, myocardial infarction and pre-eclampsia
1) Confidence 0.42 Published 1986 Journal Thromb. Res. Section Abstract Doc Link 3798419 Disease Relevance 0.48 Pain Relevance 0.09
Rituximab targets the CD20 molecule, which is selectively expressed on B cells and depletes these cells [26].
Negative_regulation (depletes) of CD20 in B cells
2) Confidence 0.41 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833979 Disease Relevance 1.04 Pain Relevance 0.39
Recent studies have made it clear that depletion of CD20+ B-cells has led to significant decreases of autoantibody titers, but the biologic relevance of these observations is still unclear.
Negative_regulation (depletion) of CD20 in B-cells
3) Confidence 0.35 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721296 Disease Relevance 0.44 Pain Relevance 0.20
The benign gastric epithelium were negative for both CK7 and CK20 (figure 2C), while the malignant colonic epithelium was positive for CK20 (figure 2C) and negative for CK7 supporting the dual population of cells in the gastric mucosal biopsies.


Negative_regulation (positive) of CK20 in gastric epithelium associated with malignant neoplastic disease
4) Confidence 0.32 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2734526 Disease Relevance 0.87 Pain Relevance 0
Although so characteristic of colorectal tumors, K20 may in certain situations be reduced.
Negative_regulation (reduced) of K20 associated with colorectal cancer
5) Confidence 0.25 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.97 Pain Relevance 0
Consequently, a decrease in the consumption of sodium and animal protein is recommended for reducing urinary calcium levels.
Negative_regulation (decrease) of animal protein
6) Confidence 0.21 Published 2006 Journal Nutr J Section Body Doc Link PMC1586208 Disease Relevance 0.63 Pain Relevance 0
CD19, CD20, CD21, CD22, CD35 receptors were found to be diminished.
Negative_regulation (diminished) of CD20
7) Confidence 0.20 Published 2004 Journal Acta Medica (Hradec Kralove) Section Abstract Doc Link 15168883 Disease Relevance 1.00 Pain Relevance 0.13
The absolute number of CD27++/CD20?
Negative_regulation (number) of CD20
8) Confidence 0.18 Published 2007 Journal J Clin Immunol Section Body Doc Link PMC2039801 Disease Relevance 0.73 Pain Relevance 0
No differences in absolute numbers of CD27++/CD20?
Negative_regulation (numbers) of CD20
9) Confidence 0.18 Published 2007 Journal J Clin Immunol Section Body Doc Link PMC2039801 Disease Relevance 0.50 Pain Relevance 0
The absolute number of CD27++/CD20?
Negative_regulation (number) of CD20
10) Confidence 0.18 Published 2007 Journal J Clin Immunol Section Body Doc Link PMC2039801 Disease Relevance 0.45 Pain Relevance 0
Analysis of PCs in blood from this patient several months later showed a normal number of CD27++/CD20?
Negative_regulation (number) of CD20 in blood
11) Confidence 0.18 Published 2007 Journal J Clin Immunol Section Body Doc Link PMC2039801 Disease Relevance 0.84 Pain Relevance 0
Gradual reductions in CD20 B cells and immunoglobulin isotypes, particularly IgM, were observed [41,42].
Negative_regulation (reductions) of CD20 in B cells
12) Confidence 0.17 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592791 Disease Relevance 0.62 Pain Relevance 0.15
Second, B cells may be depleted by monoclonal antibodies that inhibit CD19, CD20, CD21, or CD22 B cell surface antigen.
Negative_regulation (inhibit) of CD20 in B cell
13) Confidence 0.16 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833972 Disease Relevance 0.35 Pain Relevance 0.24
In general, the percentage reduction in CD20+ B cells was greater in patients treated with belimumab than in those treated with placebo (Figure 2).
Negative_regulation (reduction) of CD20 in B cells
14) Confidence 0.15 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592791 Disease Relevance 0 Pain Relevance 0
In the double-dose cohorts, the median reduction in CD20+ B cells at day 105 ranged from 27% to 43%, whereas a 5% increase was observed in the placebo group.
Negative_regulation (reduction) of CD20 in B cells
15) Confidence 0.15 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592791 Disease Relevance 0 Pain Relevance 0
On admission (day 0), both SLE patients had elevated frequencies and absolute numbers of CD27++/CD20?
Negative_regulation (numbers) of CD20 associated with systemic lupus erythematosus
16) Confidence 0.13 Published 2007 Journal J Clin Immunol Section Body Doc Link PMC2039801 Disease Relevance 0.92 Pain Relevance 0
Peripheral T cell lymphomas (PTCLs) are fatal in the majority of patients and novel treatments, such as protein tyrosine kinase (PTK) inhibition, are needed.
Negative_regulation (inhibition) of protein in T cell associated with t-cell lymphoma
17) Confidence 0.13 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 0.79 Pain Relevance 0.05
Reactive lymphocytes stained strongly for CD3, CD4, CD8, and to a lesser degree for CD20.
Negative_regulation (degree) of CD20 in lymphocytes
18) Confidence 0.12 Published 2007 Journal Diagn Pathol Section Body Doc Link PMC1808440 Disease Relevance 0.35 Pain Relevance 0
Administration of rituximab leads to selective depletion of the CD20 positive B cells from the body, leaving the stem cells and plasma cells unaffected because CD20 is not expressed on these cells.
Negative_regulation (depletion) of CD20 in body
19) Confidence 0.09 Published 2007 Journal The Open Rheumatology Journal Section Body Doc Link PMC2581826 Disease Relevance 0.63 Pain Relevance 0.46
The expression of IL-22R1 in ALK(+)ALCL is aberrant, as this protein is absent in benign lymphocytes.
Negative_regulation (absent) of protein in lymphocytes associated with anaplastic large cell lymphoma
20) Confidence 0.08 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 1.34 Pain Relevance 0

General Comments

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