INT38686

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Context Info
Confidence 0.48
First Reported 1986
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 20
Total Number 20
Disease Relevance 9.25
Pain Relevance 5.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NR3C1) nucleoplasm (NR3C1) signal transduction (NR3C1)
aging (NR3C1) nucleolus (NR3C1) nucleus (NR3C1)
Anatomy Link Frequency
nucleus 5
blood 1
amnion 1
NR3C1 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 14 100.00 Very High Very High Very High
Potency 10 100.00 Very High Very High Very High
Sumatriptan 3 99.64 Very High Very High Very High
cINOD 9 99.44 Very High Very High Very High
Thoracotomy 5 98.60 Very High Very High Very High
Inflammation 144 98.48 Very High Very High Very High
Dopamine 5 98.12 Very High Very High Very High
cytokine 61 97.90 Very High Very High Very High
corticosteroid 47 95.60 Very High Very High Very High
Lamotrigine 23 94.68 High High
Disease Link Frequency Relevance Heat
Cv General 2 Under Development 20 99.76 Very High Very High Very High
Occupational Lung Diseases 1 99.68 Very High Very High Very High
Asthma 35 99.44 Very High Very High Very High
Sepsis 132 99.28 Very High Very High Very High
INFLAMMATION 162 99.20 Very High Very High Very High
Disease 45 98.84 Very High Very High Very High
Myocardial Infarction 7 98.16 Very High Very High Very High
Cough 4 95.36 Very High Very High Very High
Depression 15 93.36 High High
Shock 2 92.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
[Changes in the characteristics of glucocorticoid hormone binding in human peripheral blood lymphocytes during myocardial infarct].
glucocorticoid hormone Binding (binding) of in blood associated with myocardial infarction
1) Confidence 0.48 Published 1986 Journal Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR Section Title Doc Link 3801148 Disease Relevance 0.37 Pain Relevance 0.18
Glucocorticoid receptor ligand binding in monocytic cells using a microplate assay.
Glucocorticoid receptor Binding (binding) of
2) Confidence 0.37 Published 1999 Journal Pathobiology Section Title Doc Link 10725798 Disease Relevance 0.09 Pain Relevance 0.14
After binding to the glucocorticoid receptor (GR), they repress the synthesis of proinflammatory cytokines via inhibition of the transcription factors AP-1 and NF-kappa B.
glucocorticoid receptor Binding (binding) of associated with cytokine
3) Confidence 0.27 Published 1999 Journal Gene Ther. Section Abstract Doc Link 10435109 Disease Relevance 0.57 Pain Relevance 0.23
Paradox of glucocorticoid-induced cytosolic phospholipase A2 group IVA messenger RNA expression involves glucocorticoid receptor binding to the promoter in human amnion fibroblasts.
glucocorticoid receptor Binding (binding) of in amnion associated with cytokine
4) Confidence 0.23 Published 2008 Journal Biol. Reprod. Section Title Doc Link 17901074 Disease Relevance 0.22 Pain Relevance 0.21
This binding was super shifted by glucocorticoid receptor antibody.
glucocorticoid receptor Binding (binding) of
5) Confidence 0.18 Published 2008 Journal Biol. Reprod. Section Abstract Doc Link 17901074 Disease Relevance 0.15 Pain Relevance 0.11
Nongenomic effects are probably subsequent to cytosolic interaction between the glucocorticoid receptor and proteins, or to interaction between glucocorticoids and specific membrane binding sites.



glucocorticoid receptor Binding (interaction) of
6) Confidence 0.17 Published 2004 Journal Crit Care Section Abstract Doc Link PMC522845 Disease Relevance 0.46 Pain Relevance 0.03
Glucocorticoids interact with a specific cytosolic glucocorticoid receptor, which undergoes conformational changes, sheds heat shock proteins and translocates to the nucleus.
cytosolic glucocorticoid receptor Binding (interact) of in nucleus associated with cv general 2 under development
7) Confidence 0.17 Published 2004 Journal Crit Care Section Abstract Doc Link PMC522845 Disease Relevance 0.59 Pain Relevance 0.04
The R-epimer has a considerably higher binding affinity to the glucocorticoid receptor as compared to the S-epimer, and therefore only R-epimer is developed for clinical use (Schmidt et al 1999).


glucocorticoid receptor Binding (affinity) of
8) Confidence 0.14 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504079 Disease Relevance 0.39 Pain Relevance 0.14
Glucocorticoids interact with a specific cytosolic glucocorticoid receptor, which undergoes conformational changes, sheds heat shock proteins and translocates to the nucleus.
cytosolic glucocorticoid receptor Binding (sheds) of in nucleus associated with cv general 2 under development
9) Confidence 0.13 Published 2004 Journal Crit Care Section Abstract Doc Link PMC522845 Disease Relevance 0.58 Pain Relevance 0.04
Decreased glucocorticoid receptor number/affinity
glucocorticoid receptor Binding (affinity) of
10) Confidence 0.12 Published 2004 Journal Crit Care Section Body Doc Link PMC522845 Disease Relevance 0.41 Pain Relevance 0.23
-hydroxylase (DBH), glucocorticoid receptor (NR3C1), histamine H1 receptor (HRH1) and melanocortin 2 receptor (MCR2) genes were associated with the treatment response.
NR3C1 Binding (associated) of
11) Confidence 0.11 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958627 Disease Relevance 0.43 Pain Relevance 0.45
In the classic mode of action, GCs diffuse into the cytoplasm and bind to the ubiquitous glucocorticoid receptor (cGCR).
cGCR Binding (bind) of
12) Confidence 0.06 Published 2008 Journal International Journal of Nanomedicine Section Body Doc Link PMC2626937 Disease Relevance 1.07 Pain Relevance 0.77
In the classic mode of action, GCs diffuse into the cytoplasm and bind to the ubiquitous glucocorticoid receptor (cGCR).
glucocorticoid receptor Binding (bind) of
13) Confidence 0.06 Published 2008 Journal International Journal of Nanomedicine Section Body Doc Link PMC2626937 Disease Relevance 1.07 Pain Relevance 0.77
They act by binding to the glucocorticoid receptor (GR) that, upon activation, translocates to the nucleus and either stimulates or inhibits gene expression.
glucocorticoid receptor Binding (binding) of in nucleus
14) Confidence 0.05 Published 2004 Journal Mech. Ageing Dev. Section Abstract Doc Link 15541765 Disease Relevance 0.40 Pain Relevance 0.21
VAST scores were significantly lower in Gr B at 12, 16, 28, and 32 h when compared with Gr P and Gr L (P < 0.05).
Gr L Binding (compared) of associated with thoracotomy
15) Confidence 0.04 Published 1995 Journal Anesth. Analg. Section Abstract Doc Link 7893024 Disease Relevance 0.43 Pain Relevance 1.14
The 5-HT1D receptor antagonist GR127935 is markedly more potent against sumatriptan than against the sensitive portion of 5-HT effect.
GR127935 Binding (potent) of associated with sumatriptan and antagonist
16) Confidence 0.02 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9016944 Disease Relevance 0.23 Pain Relevance 0.66
Its binding and antagonist potency with respect to the glucocorticoid receptor is significantly reduced compared to that of mifepristone, indicating that UPA belongs to a new type of dissociated progesterone receptor modulators that have reduced antiglucorticoid activity.13,15–17 The chemical structure of progesterone, LNG and UPA is depicted in Figure 1.
glucocorticoid receptor Binding (binding) of associated with antagonist and potency
17) Confidence 0.02 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971744 Disease Relevance 0.11 Pain Relevance 0.10
Glucocorticoids exert their pharmacological effects by binding to a glucocorticoid receptor (GR), which promotes expression of its target genes or suppresses transcription mediated by other transcriptional factors, such as nuclear factor-kappaB (NF-kappaB).
glucocorticoid receptor Binding (binding) of
18) Confidence 0.02 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12954798 Disease Relevance 0.10 Pain Relevance 0.10
They act by binding to a specific glucocorticoid receptor (GR) that on activation translocates to the nucleus and either increases (transactivates) or decreases (transrepresses) the expression of responsive genes.
glucocorticoid receptor Binding (binding) of in nucleus
19) Confidence 0.01 Published 2001 Journal Immunol. Cell Biol. Section Abstract Doc Link 11488985 Disease Relevance 1.00 Pain Relevance 0.34
The glucocorticoid–receptor interaction causes a receptor conformational change which leads to regulatory protein detachment, dimerization of the glucocorticoid receptor complexes and translocation to the nucleus where the drug-receptor complex binds to specific regulatory DNA sequences (glucocorticoid response elements, GRE), which modulate the expression of the adjacent genes.
glucocorticoid receptor Binding (dimerization) of in nucleus
20) Confidence 0.01 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2707800 Disease Relevance 0.58 Pain Relevance 0.12

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