INT3869

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Context Info
Confidence 0.37
First Reported 1977
Last Reported 2011
Negated 1
Speculated 2
Reported most in Body
Documents 7
Total Number 22
Disease Relevance 3.60
Pain Relevance 3.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (SHMT2) methyltransferase activity (SHMT2)
Anatomy Link Frequency
melanocytes 6
cell groups 2
embryos 1
ileum 1
neurons 1
SHMT2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Serotonin 437 100.00 Very High Very High Very High
Enkephalin 6 99.76 Very High Very High Very High
Central grey 12 99.74 Very High Very High Very High
Spinal cord 18 99.28 Very High Very High Very High
opiate 1 98.32 Very High Very High Very High
Dorsal horn 2 98.04 Very High Very High Very High
Neurotransmitter 6 96.24 Very High Very High Very High
opioid receptor 2 95.82 Very High Very High Very High
Opioid 3 94.88 High High
potassium channel 120 91.92 High High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 13 99.74 Very High Very High Very High
Cancer 480 99.32 Very High Very High Very High
Paralysis 15 92.72 High High
Nociception 9 92.40 High High
Disease 19 88.60 High High
Pigment Disorder 480 83.76 Quite High
Anxiety Disorder 4 80.12 Quite High
Congenital Anomalies 45 77.68 Quite High
Skin Cancer 150 72.92 Quite High
Hypopigmentation 15 70.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the paw shacking test, GLY produced only hypernociception with the higher dose.
Gene_expression (produced) of GLY in paw
1) Confidence 0.37 Published 2010 Journal Behav. Brain Res. Section Abstract Doc Link 20561964 Disease Relevance 1.08 Pain Relevance 0.14
Exposure of Caco-2 cell monolayers to the hPepT1 substrate Gly–Gln for 4 days resulted in a subsequent increase in capacity for dipeptide uptake and in hPepT1 expression [31].
Gene_expression (substrate) of Gly in Caco-2
2) Confidence 0.07 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2428106 Disease Relevance 0.09 Pain Relevance 0.04
M) significantly reduced Gly–Sar uptake in a manner similar to that caused by the removal of extracellular Na+ (p < 0.001).
Gene_expression (reduced) of Gly
3) Confidence 0.07 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2428106 Disease Relevance 0 Pain Relevance 0.04
To find a delta-opioid receptor preferring peptide structure containing an Asp residue in a potentially interacting position, Tyr-Pro-Phe-Asp, Tyr-D-Ala-Phe-Asp, Tyr-D-Ala-Gly-Phe-Asp, Tyr-D-Ala-Gly-Phe-Asp alpha- and beta-methyl ester and Tyr-Gly-Gly-Phe-Asp peptides were synthesized and their biological activities were analyzed in vitro in mouse vas deferens and longitudinal muscle strip of guinea pig ileum.
Gene_expression (synthesized) of Tyr-Gly-Gly-Phe-Asp in ileum associated with opioid receptor
4) Confidence 0.04 Published 1994 Journal Pharmacology Section Abstract Doc Link 7972321 Disease Relevance 0 Pain Relevance 0.19
The synthesis of H-Tyr-Gly-Gly-Phe-Leu-OH (Leu-enkephalin), endogenus peptide with opiate-like activity, and two rearrangements concerning Leu-enkephalin N-terminus are described.
Gene_expression (synthesis) of H-Tyr-Gly-Gly-Phe-Leu-OH associated with opiate and enkephalin
5) Confidence 0.02 Published 1977 Journal Farmaco Sci Section Abstract Doc Link 891912 Disease Relevance 0 Pain Relevance 0.37
The present study was designed to determine whether PAG stimulation produces the release of serotonin (5-HT), norepinephrine (NE), Gly, and gamma-aminobutyric acid in the spinal cord dorsal horn and whether the release of these neurotransmitters by PAG stimulation is associated with a long-lasting inhibition of the evoked nociceptive responses of dorsal horn neurons.
Spec (whether) Gene_expression (produces) of Gly in neurons associated with nociception, neurotransmitter, dorsal horn, dorsal horn neuron, serotonin, central grey and spinal cord
6) Confidence 0.02 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10215665 Disease Relevance 0.72 Pain Relevance 0.96
Three new peptides, with a substitution of a single amino acid, were synthesized (Mel-Gly-Gly-Phe-Met-Arg-Phe, Tyr-Gly-Gly-Mel-Met-Arg-Phe and Tyr-Gly-Gly-Phe-Met-Arg-Mel).
Gene_expression (synthesized) of Tyr-Gly-Gly-Mel-Met-Arg-Phe
7) Confidence 0.02 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10414445 Disease Relevance 0 Pain Relevance 0.50
Whereas GlyCl is normally expressed in some neurons (spinal cord, retina) and sperm (Lynch, 2009), we detected a dynamic and highly interesting distribution during frog embryogenesis.
Gene_expression (expressed) of GlyCl in sperm associated with spinal cord
8) Confidence 0.01 Published 2011 Journal Disease Models & Mechanisms Section Body Doc Link PMC3008964 Disease Relevance 0.29 Pain Relevance 0.09
Therefore, we developed a strategy capitalizing on the ability to control the native glycine receptor chloride channel (GlyCl), and thereby control the steady-state transmembrane potential of GlyCl-expressing embryonic cells.
Gene_expression (expressing) of GlyCl in embryonic cells
9) Confidence 0.01 Published 2011 Journal Disease Models & Mechanisms Section Body Doc Link PMC3008964 Disease Relevance 0.09 Pain Relevance 0.08
Interestingly, sustained ivermectin treatment in Xenopus does not result in generalized runaway hyperproliferation but affects a specific cell type; it remains to be understood why the GlyCl-expressing cells instruct only melanocytes and not other cell types.
Gene_expression (expressing) of GlyCl in melanocytes
10) Confidence 0.01 Published 2011 Journal Disease Models & Mechanisms Section Body Doc Link PMC3008964 Disease Relevance 0.06 Pain Relevance 0.03
Transmembrane potential of GlyCl-expressing instructor cells induces a neoplastic-like conversion of melanocytes via a serotonergic pathway
Gene_expression (expressing) of GlyCl in melanocytes
11) Confidence 0.01 Published 2011 Journal Disease Models & Mechanisms Section Title Doc Link PMC3008964 Disease Relevance 0.08 Pain Relevance 0
Molecular-genetic or pharmacological depolarization of GlyCl-expressing cells confers a neoplasia-like phenotype on melanocytes: they overproliferate, become arborized and inappropriately colonize numerous tissues in a metalloprotease-dependent fashion.
Gene_expression (expressing) of GlyCl in melanocytes associated with cancer
12) Confidence 0.01 Published 2011 Journal Disease Models & Mechanisms Section Body Doc Link PMC3008964 Disease Relevance 0.10 Pain Relevance 0.08
We conclude that the ivermectin target GlyCl is expressed in embryos, first in a neural-crest-associated pattern and later in a sparse punctate pattern throughout the embryo that is specifically absent from the neural crest cells themselves.
Gene_expression (expressed) of GlyCl in embryos
13) Confidence 0.01 Published 2011 Journal Disease Models & Mechanisms Section Body Doc Link PMC3008964 Disease Relevance 0 Pain Relevance 0.04
To identify the embryonic source of the signals induced by ivermectin, we investigated which cells expressed the ivermectin target GlyCl (a ligand-gated chloride channel consisting of a primary ?
Spec (investigated) Gene_expression (expressed) of GlyCl
14) Confidence 0.01 Published 2011 Journal Disease Models & Mechanisms Section Body Doc Link PMC3008964 Disease Relevance 0.12 Pain Relevance 0.03
Molecular-genetic depolarization of a sparse, widely distributed set of GlyCl-expressing cells non-cell-autonomously induces a neoplastic-like phenotype in melanocytes: they overproliferate, acquire an arborized cell shape and migrate inappropriately, colonizing numerous tissues in a metalloprotease-dependent fashion.
Gene_expression (expressing) of GlyCl in melanocytes
15) Confidence 0.01 Published 2011 Journal Disease Models & Mechanisms Section Abstract Doc Link PMC3008964 Disease Relevance 0.07 Pain Relevance 0.07
However, our in vivo experiments revealed a non-cell-autonomous instructive function for GlyCl-expressing cells that would not be apparent from in vitro experiments: depolarization can induce a neoplastic-like phenotype in cells that themselves are not (yet) depolarized (Fig. 4).
Gene_expression (expressing) of GlyCl
16) Confidence 0.01 Published 2011 Journal Disease Models & Mechanisms Section Body Doc Link PMC3008964 Disease Relevance 0.31 Pain Relevance 0.17
Analysis of expression of other ion channels and pumps might reveal yet other subsets of otherwise homogenous-seeming cell groups, which, like the GlyCl-expressing cells, could be tractable targets for modulation in regenerative medicine.
Gene_expression (expressing) of GlyCl in cell groups
17) Confidence 0.01 Published 2011 Journal Disease Models & Mechanisms Section Body Doc Link PMC3008964 Disease Relevance 0.06 Pain Relevance 0.03
Analysis of expression of other ion channels and pumps might reveal yet other subsets of otherwise homogenous-seeming cell groups, which, like the GlyCl-expressing cells, could be tractable targets for modulation in regenerative medicine.
Gene_expression (-) of GlyCl in cell groups
18) Confidence 0.01 Published 2011 Journal Disease Models & Mechanisms Section Body Doc Link PMC3008964 Disease Relevance 0.05 Pain Relevance 0.03
However, our data specifically connect the control of Vmem in one cell population (GlyCl-expressing instructor cells) with migration, morphology and proliferation in another (pigment cells).
Gene_expression (expressing) of GlyCl in pigment cells
19) Confidence 0.01 Published 2011 Journal Disease Models & Mechanisms Section Body Doc Link PMC3008964 Disease Relevance 0.17 Pain Relevance 0
Depolarization of GlyCl-expressing cells induces these drastic changes in melanocyte behavior via a serotonin-transporter-dependent increase of extracellular serotonin (5-HT).
Gene_expression (expressing) of GlyCl in melanocyte associated with serotonin
20) Confidence 0.01 Published 2011 Journal Disease Models & Mechanisms Section Abstract Doc Link PMC3008964 Disease Relevance 0.06 Pain Relevance 0.10

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