INT387

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Context Info
Confidence 0.45
First Reported 1979
Last Reported 2010
Negated 6
Speculated 3
Reported most in Abstract
Documents 18
Total Number 21
Disease Relevance 5.24
Pain Relevance 4.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ace) peptidase activity (Ace) extracellular space (Ace)
extracellular region (Ace) plasma membrane (Ace)
Anatomy Link Frequency
plasma 3
blood 1
endothelial cells 1
ACe 1
abdominal aorta 1
Ace (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 15 100.00 Very High Very High Very High
bradykinin 45 99.80 Very High Very High Very High
substance P 4 99.76 Very High Very High Very High
Potency 3 97.68 Very High Very High Very High
B1 receptor 91 97.24 Very High Very High Very High
Enkephalin 5 96.64 Very High Very High Very High
Calcitonin gene-related peptide 1 95.16 Very High Very High Very High
ketamine 7 92.08 High High
qutenza 4 91.60 High High
Neurotransmitter 1 91.12 High High
Disease Link Frequency Relevance Heat
Stress 45 99.84 Very High Very High Very High
Hypersensitivity 3 99.68 Very High Very High Very High
Increased Venous Pressure Under Development 2 98.68 Very High Very High Very High
Targeted Disruption 3 97.84 Very High Very High Very High
Renal Disease 3 96.76 Very High Very High Very High
Pressure And Volume Under Development 32 96.64 Very High Very High Very High
INFLAMMATION 33 94.32 High High
Injury 16 93.80 High High
Ureteral Obstruction 6 93.68 High High
Hypertension 11 93.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The purpose of this study was to evaluate the effect of angiotensin-converting enzyme (ACE) inhibition on collateral-dependent blood flow (BF) during exercise.
Regulation (effect) of ACE in blood
1) Confidence 0.45 Published 1993 Journal J. Appl. Physiol. Section Abstract Doc Link 8397181 Disease Relevance 0 Pain Relevance 0.12
Our data may suggest that kininase II is not involved in the hypersensitivity to bradykinin in late pregnancy in rats.
Neg (not) Regulation (involved) of kininase II associated with hypersensitivity and bradykinin
2) Confidence 0.44 Published 1989 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 2551002 Disease Relevance 0.18 Pain Relevance 0.41
The effects of long-term angiotensin-converting enzyme (ACE) inhibitor treatment with perindopril 2 mg/kg/day, by gavage, for 3 months on the mechanical function and structure of large arteries were studied in adult spontaneously hypertensive rats with established hypertension.
Regulation (effects) of ACE associated with hypertension
3) Confidence 0.44 Published 1993 Journal Am. J. Cardiol. Section Abstract Doc Link 8328370 Disease Relevance 0.26 Pain Relevance 0.07
Because angiotensin is necessary for normal renal development, we examined the effects of ACE inhibition both during and immediately following the period of postnatal nephrogenesis in the neonatal rat subjected to sham operation or partial unilateral ureteral obstruction (UUO) under general anesthesia within the first 48 h of life.
Spec (examined) Regulation (effects) of ACE associated with ureteral obstruction and anesthesia
4) Confidence 0.43 Published 2007 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 17107943 Disease Relevance 0.82 Pain Relevance 0.09
We also studied the effect of a selective inhibitor (captopril, 2.5 mg/kg) of the tachykinin-degrading enzyme kininase II [or angiotensin-converting enzyme (ACE)] on substance P-induced airway vasodilation.
Regulation (effect) of ACE associated with increased venous pressure under development and substance p
5) Confidence 0.39 Published 1993 Journal J. Appl. Physiol. Section Abstract Doc Link 7687598 Disease Relevance 0.33 Pain Relevance 0.55
To determine the effects of anesthetic agents on angiotensin I conversion, experiments were performed in vitro and in vivo.
Spec (determine) Regulation (effects) of angiotensin I
6) Confidence 0.38 Published 1979 Journal Anesthesiology Section Abstract Doc Link 35043 Disease Relevance 0 Pain Relevance 0.70
Losartan plus L-NAME treatment caused an increase in plasma ACE activity above control.
Regulation (control) of ACE in plasma
7) Confidence 0.38 Published 2004 Journal Recept. Channels Section Abstract Doc Link 15989079 Disease Relevance 0.39 Pain Relevance 0.06
We investigated the influence of the angiotensin-converting enzyme (ACE) inhibitor ramipril on cardiac arrhythmias in guinea pigs and rats.
Spec (investigated) Regulation (influence) of ACE
8) Confidence 0.37 Published 1989 Journal Cardiovasc Drugs Ther Section Abstract Doc Link 2535056 Disease Relevance 0 Pain Relevance 0.15
The change in serum ACE activity may be due to time-requiring perturbations in the pulmonary endothelial cells.
Regulation (change) of ACE in endothelial cells
9) Confidence 0.27 Published 1982 Journal J Toxicol Environ Health Section Abstract Doc Link 6176718 Disease Relevance 0 Pain Relevance 0.08
The experimental conditions also did not affect the integrity of the endothelial layer since perfusate levels of ACE did not change during perfusion.
Neg (not) Regulation (change) of ACE
10) Confidence 0.24 Published 2005 Journal Part Fibre Toxicol Section Body Doc Link PMC1180470 Disease Relevance 0.32 Pain Relevance 0
This suggests that the PVN and the ACe are two major targets of stress in the brain.
Regulation (targets) of ACe in ACe associated with stress
11) Confidence 0.21 Published 1992 Journal Neuroreport Section Abstract Doc Link 1421086 Disease Relevance 0.36 Pain Relevance 0.13
Lisinopril significantly reduced serum ACE activity but it did not affect pancreatic activity.
Neg (not) Regulation (affect) of serum ACE
12) Confidence 0.19 Published 2003 Journal Gastroenterology Section Body Doc Link 12671898 Disease Relevance 0.07 Pain Relevance 0
The K(m), V(max), K(cat) and K(cat)/K(m) values of gACE at optimal pH (pH 7.2) were 680 microM, 1.0 micromol/mg/min, 33.1 s(-1) and 4.87 x 10(4) s(-1) M(-1) for Z-Val-Lys-Met-MCA, respectively. gACE was potently inhibited by EDTA, 1,10-phenanthroline, captopril and lisinopril, and it promptly released the dipeptides His-Leu and Phe-Arg from angiotensin I and bradykinin.
Regulation (values) of gACE associated with bradykinin
13) Confidence 0.19 Published 2007 Journal Comp. Biochem. Physiol. B, Biochem. Mol. Biol. Section Abstract Doc Link 17145192 Disease Relevance 0 Pain Relevance 0.12
When comparing the effects of a cell therapy approach (BMMNCs) versus the pharmacological one (ACE-I), we observed that the reduction in the pro-Cks was similar in both treatment groups for IL-1?
Regulation (effects) of ACE
14) Confidence 0.16 Published 2008 Journal J Transl Med Section Body Doc Link PMC2435101 Disease Relevance 0.51 Pain Relevance 0.27
Effect of N-[(S)-1-carboxy-3-phenylpropyl]-L-Ala-L-Pro and its ethyl ester (MK-421) on angiotensin converting enzyme in vitro and angiotensin I pressor responses in vivo.
Regulation (Effect) of angiotensin I associated with anesthesia
15) Confidence 0.15 Published 1981 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 6259322 Disease Relevance 0 Pain Relevance 0.14
Inhibition of the pressor effects of angiotensin I by the diacid ACE inhibitor occurred at an ID50 of 8.2 micrograms/kg i.v. in rats and 6.4 micrograms/kg i.v. in dogs.
Regulation (effects) of angiotensin I
16) Confidence 0.15 Published 1981 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6259322 Disease Relevance 0 Pain Relevance 0.05
The synaptic membrane dipeptidyl carboxypeptidase is inhibited by metal chelating agents and thiols but is not affected by compounds known to inhibit serine proteases, thermolysin and "enkephalinase".
Neg (not) Regulation (affected) of dipeptidyl carboxypeptidase
17) Confidence 0.12 Published 1983 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 6349637 Disease Relevance 0 Pain Relevance 0.26
For instance, genetic disruption of B1R or B2R and both receptors decreased ACE and ANG II AT1R function and expression in mice abdominal aorta, indicating that kinin receptors regulate AT1 receptors and ACE [76], [77].
Regulation (regulate) of ACE in abdominal aorta associated with b1 receptor
18) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935380 Disease Relevance 1.17 Pain Relevance 0.39
EB-382 did not affect the kinin-forming enzyme and kininase activities of rat plasma in vitro.
Neg (not) Regulation (affect) of kininase in plasma
19) Confidence 0.09 Published 1989 Journal Chem. Pharm. Bull. Section Abstract Doc Link 2752492 Disease Relevance 0.56 Pain Relevance 0.18
However, emorfazone had no direct effect on the content of kininogen, kinin-forming enzyme and kininase activity in rats plasma.
Neg (no) Regulation (effect) of kininase in plasma
20) Confidence 0.09 Published 1982 Journal Arzneimittelforschung Section Abstract Doc Link 7201806 Disease Relevance 0.22 Pain Relevance 0.32

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