INT3870

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Context Info
Confidence 0.58
First Reported 1977
Last Reported 2006
Negated 0
Speculated 2
Reported most in Abstract
Documents 18
Total Number 20
Disease Relevance 1.90
Pain Relevance 8.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Sct)
Anatomy Link Frequency
plasma 6
blood 4
cholinergic neurons 4
Sct (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 46 100.00 Very High Very High Very High
gABA 24 100.00 Very High Very High Very High
anesthesia 2 100.00 Very High Very High Very High
Dopamine 1 100.00 Very High Very High Very High
Somatostatin 54 99.36 Very High Very High Very High
Bile 4 97.20 Very High Very High Very High
narcan 30 97.04 Very High Very High Very High
qutenza 12 96.16 Very High Very High Very High
tetrodotoxin 12 94.32 High High
GABAergic 7 90.80 High High
Disease Link Frequency Relevance Heat
Hyperinsulinism 1 100.00 Very High Very High Very High
Nicotine Addiction 8 99.68 Very High Very High Very High
Bordatella Infection 2 97.34 Very High Very High Very High
Diarrhoea 2 93.48 High High
Cramps 1 93.04 High High
Duodenal Ulcer 3 92.88 High High
Body Weight 1 88.12 High High
Volume Depletion And Dehydration 1 87.28 High High
Gastroesophageal Reflux Disease 1 81.64 Quite High
Vomiting 1 80.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
GABA-stimulated secretin secretion was neuronal in nature, bicuculline sensitive and was mediated via post ganglionic cholinergic neurons.
Positive_regulation (stimulated) of Localization (secretion) of secretin in cholinergic neurons associated with gaba
1) Confidence 0.58 Published 1986 Journal Peptides Section Abstract Doc Link 2875446 Disease Relevance 0 Pain Relevance 0.50
GABA (10(-9) to 10(-6) M) stimulated both basal and pH 4.5-stimulated secretin secretion.
Positive_regulation (stimulated) of Localization (secretion) of secretin associated with gaba
2) Confidence 0.58 Published 1986 Journal Peptides Section Abstract Doc Link 2875446 Disease Relevance 0 Pain Relevance 0.50
GABA-stimulated secretin secretion was neuronal in nature, bicuculline sensitive and was mediated via post ganglionic cholinergic neurons.
Positive_regulation (mediated) of Localization (secretion) of secretin in cholinergic neurons associated with gaba
3) Confidence 0.58 Published 1986 Journal Peptides Section Abstract Doc Link 2875446 Disease Relevance 0 Pain Relevance 0.50
In contrast, CAP from donor rats pretreated with phentolamine, atropine, or hexamethonium did not alter the increase in plasma secretin concentration and pancreatic secretion.
Positive_regulation (increase) of Localization (secretion) of plasma secretin in plasma
4) Confidence 0.57 Published 1995 Journal Am. J. Physiol. Section Abstract Doc Link 7653572 Disease Relevance 0 Pain Relevance 0.53
In conclusion, the release and action of both SRP and secretin are mediated by a vagal afferent pathway. beta-Adrenergic receptors also play a significant role in the release of SRP.
Positive_regulation (mediated) of Localization (release) of secretin
5) Confidence 0.47 Published 1995 Journal Am. J. Physiol. Section Abstract Doc Link 7653572 Disease Relevance 0 Pain Relevance 0.49
The acid-stimulated release of secretin is mediated by a secretin-releasing peptide (SRP) in rats.
Positive_regulation (mediated) of Localization (release) of secretin
6) Confidence 0.44 Published 1995 Journal Am. J. Physiol. Section Abstract Doc Link 7653572 Disease Relevance 0 Pain Relevance 0.11
Somatostatin (10(-7) to 10(-8) M) inhibited secretin secretion stimulated by pH 4.5.
Positive_regulation (stimulated) of Localization (secretion) of secretin associated with somatostatin
7) Confidence 0.42 Published 1986 Journal Peptides Section Abstract Doc Link 2875446 Disease Relevance 0 Pain Relevance 0.45
GABA-stimulated secretin secretion was inhibited by both somatostatin and metenkephalin, suggesting that GABA-stimulated secretin secretion may be under the inhibitory control of peptidergic agents as well.
Positive_regulation (GABA-stimulated) of Localization (secretion) of secretin associated with gaba and somatostatin
8) Confidence 0.42 Published 1986 Journal Peptides Section Abstract Doc Link 2875446 Disease Relevance 0 Pain Relevance 0.49
GABA (10(-9) to 10(-6) M) stimulated both basal and pH 4.5-stimulated secretin secretion.
Positive_regulation (4.5-stimulated) of Localization (secretion) of secretin associated with gaba
9) Confidence 0.42 Published 1986 Journal Peptides Section Abstract Doc Link 2875446 Disease Relevance 0 Pain Relevance 0.50
These symptoms are to a large extent induced by the degree of decrease in GI blood flow and the secretion of secretory substances such as vasoactive intestinal peptide, secretin and peptide-histidine-methionine.
Positive_regulation (induced) of Localization (secretion) of secretin in blood
10) Confidence 0.42 Published 1993 Journal Sports Med Section Abstract Doc Link 8460288 Disease Relevance 0.60 Pain Relevance 0
Secretin and pancreatic islet blood flow in anesthetized rats: increased insulin secretion with no augmentation of blood perfusion.
Positive_regulation (increased) of Localization (secretion) of Secretin in blood associated with anesthesia and hyperinsulinism
11) Confidence 0.41 Published 2001 Journal World J Surg Section Title Doc Link 11572020 Disease Relevance 0.19 Pain Relevance 0.10
Pancreatic microflow and pancreatic exocrine secretion increased after intravenous administration of Dopamine and Secretin (10 micrograms/kg/min).
Positive_regulation (increased) of Localization (secretion) of Secretin associated with dopamine
12) Confidence 0.40 Published 1986 Journal Nippon Geka Gakkai Zasshi Section Abstract Doc Link 3785133 Disease Relevance 0 Pain Relevance 0.12
The effect of intravenous MEK on acid-stimulated secretin release and pancreatic exocrine secretion was then studied with or without coinfusion of naloxone, an anti-somatostatin (SS) serum, or normal rabbit serum.
Positive_regulation (acid-stimulated) of Localization (release) of secretin associated with somatostatin, narcan and enkephalin
13) Confidence 0.40 Published 2001 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 11292597 Disease Relevance 0 Pain Relevance 0.90
We investigated the mechanism of action of methionine enkephalin (MEK) on HCl-stimulated secretin release and pancreatic exocrine secretion.
Spec (investigated) Positive_regulation (pancreatic) of Localization (release) of secretin associated with enkephalin
14) Confidence 0.40 Published 2001 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 11292597 Disease Relevance 0 Pain Relevance 0.68
We investigated the mechanism of action of methionine enkephalin (MEK) on HCl-stimulated secretin release and pancreatic exocrine secretion.
Spec (investigated) Positive_regulation (action) of Localization (release) of secretin associated with enkephalin
15) Confidence 0.40 Published 2001 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 11292597 Disease Relevance 0 Pain Relevance 0.67
In recipient rats, CAP increased plasma secretin level and pancreatic secretion.
Positive_regulation (increased) of Localization (secretion) of secretin in plasma
16) Confidence 0.40 Published 2001 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 11292597 Disease Relevance 0 Pain Relevance 1.30
When pertussis toxin (200 ng/ml) or rabbit antisomatostatin serum (0.1 ml/10 ml; titer of 1:50,000) was intra-arterially administered, EFS further increased the secretin-stimulated pancreatic secretion.
Positive_regulation (increased) of Localization (secretion) of secretin associated with bordatella infection
17) Confidence 0.40 Published 1998 Journal Am. J. Physiol. Section Abstract Doc Link 9486197 Disease Relevance 0.10 Pain Relevance 0.16
EFS further increased the secretin (12 pM)-stimulated pancreatic secretion of fluid and amylase.
Positive_regulation (increased) of Localization (secretion) of secretin
18) Confidence 0.40 Published 1998 Journal Am. J. Physiol. Section Abstract Doc Link 9486197 Disease Relevance 0.08 Pain Relevance 0.14
Simultaneous measurement of basal pancreatic, gastric acid secretion, plasma gastrin, and secretin during smoking.
Positive_regulation (measurement) of Localization (secretion) of secretin in plasma associated with nicotine addiction
19) Confidence 0.31 Published 1977 Journal Gastroenterology Section Title Doc Link 892379 Disease Relevance 0.94 Pain Relevance 0.06
Incubation of the hypothalamic explants with KCl induces the release of secretin to 4.35 +/- 0.45-fold of the basal level.
Positive_regulation (induces) of Localization (release) of secretin
20) Confidence 0.30 Published 2006 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 16888165 Disease Relevance 0 Pain Relevance 0.29

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