INT38712

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Context Info
Confidence 0.39
First Reported 1987
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 8
Disease Relevance 0.77
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Atp7a) transport (Atp7a) Golgi apparatus (Atp7a)
endoplasmic reticulum (Atp7a) mitochondrion organization (Atp7a) plasma membrane (Atp7a)
Anatomy Link Frequency
hinge 1
Atp7a (Mus musculus)
Pain Link Frequency Relevance Heat
analgesia 2 99.08 Very High Very High Very High
Central nervous system 3 90.88 High High
Potency 2 62.56 Quite High
Calcium channel 3 50.00 Quite Low
Analgesic 1 25.00 Low Low
cytokine 42 5.00 Very Low Very Low Very Low
agonist 36 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
local anesthetic 4 5.00 Very Low Very Low Very Low
potassium channel 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 108 100.00 Very High Very High Very High
Tremor 4 99.24 Very High Very High Very High
Apoptosis 102 77.12 Quite High
Diffuse Cutaneous Leishmaniasis 444 50.00 Quite Low
Leishmaniasis 300 41.12 Quite Low
Death 42 5.48 Low Low
Disease 72 5.00 Very Low Very Low Very Low
Viral Infection 12 5.00 Very Low Very Low Very Low
Hypersensitivity 12 5.00 Very Low Very Low Very Low
Chronic Disease 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The aziridinium ion (BR 401A), formed by cyclization of BR 401, produced salivation but no tremor.
Neg (no) Gene_expression (produced) of BR 401A associated with tremor
1) Confidence 0.39 Published 1987 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3806401 Disease Relevance 0.29 Pain Relevance 0.34
CD8 and MO purification
Gene_expression (purification) of MO
2) Confidence 0.05 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2970528 Disease Relevance 0.08 Pain Relevance 0
Both CD8 and MO were maintained at 37°C in a humidified atmosphere containing 5% CO2 incubator for 12 h before stimulus in order to reach a resting condition.


Gene_expression (maintained) of MO
3) Confidence 0.05 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2970528 Disease Relevance 0.09 Pain Relevance 0
Position i29 is four helical turns closer to the cytoplasm than position i14, where the gating-hinge glycine is located in K+ channels.
Gene_expression (position) of i14 in hinge
4) Confidence 0.05 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2828909 Disease Relevance 0 Pain Relevance 0
MO infection
Gene_expression (infection) of MO associated with infection
5) Confidence 0.04 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2970528 Disease Relevance 0.10 Pain Relevance 0
The negative fraction was processed again in order to purify MO (1×107 cells in 40 µl of PBS with 10 µl of anti-CD14 microbeads).
Gene_expression (microbeads) of MO
6) Confidence 0.04 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2970528 Disease Relevance 0.14 Pain Relevance 0
Briefly, 1×106 CD8 were mixed with autologous 1×105 MOi or MO in 24 well clear flat bottom ultra low attachment plates and incubated at 37°C with 5% CO2 for 4 h.
Gene_expression (mixed) of MO
7) Confidence 0.04 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2970528 Disease Relevance 0 Pain Relevance 0
Briefly, MO or MOi were labeled with 100 µCi of 51Cr (Perkin Elmer) for 1 h at 37°C, 5% CO2.
Gene_expression (labeled) of MO
8) Confidence 0.04 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2970528 Disease Relevance 0.08 Pain Relevance 0

General Comments

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