INT38731

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Context Info
Confidence 0.81
First Reported 1987
Last Reported 2010
Negated 1
Speculated 4
Reported most in Abstract
Documents 138
Total Number 146
Disease Relevance 52.73
Pain Relevance 90.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Trpv1) plasma membrane (Trpv1) lipid metabolic process (Trpv1)
Anatomy Link Frequency
neurons 26
nerve 8
brain 7
DRG 7
nociceptors 6
Trpv1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 1969 100.00 Very High Very High Very High
dorsal root ganglion 867 100.00 Very High Very High Very High
Pain 795 100.00 Very High Very High Very High
Calcitonin gene-related peptide 693 100.00 Very High Very High Very High
Inflammation 521 100.00 Very High Very High Very High
nociceptor 266 100.00 Very High Very High Very High
substance P 168 100.00 Very High Very High Very High
Neuropeptide 100 100.00 Very High Very High Very High
Sciatic nerve 63 100.00 Very High Very High Very High
Cannabinoid receptor 46 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 1344 100.00 Very High Very High Very High
Pain 766 100.00 Very High Very High Very High
INFLAMMATION 505 100.00 Very High Very High Very High
Nociception 388 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 48 100.00 Very High Very High Very High
Diabetes Mellitus 14 99.92 Very High Very High Very High
Injury 315 99.88 Very High Very High Very High
Anaplastic Astrocytoma 6 99.84 Very High Very High Very High
Pancreatitis 5 99.78 Very High Very High Very High
Death 34 99.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The vanilloid receptor-1 (VR1) is activated by capsaicin, heat and protons and is localized on primary sensory neurons.
Localization (localized) of vanilloid receptor-1 in primary sensory neurons associated with qutenza
1) Confidence 0.81 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11524156 Disease Relevance 0.09 Pain Relevance 0.38
The localization of VR1 in the stomach was investigated immunohistochemically.
Spec (investigated) Localization (localization) of VR1 in stomach
2) Confidence 0.81 Published 2004 Journal Scand. J. Gastroenterol. Section Body Doc Link 15125461 Disease Relevance 0 Pain Relevance 0
The vanilloid receptor-1 (VR1) is activated by capsaicin, heat and protons and is localized on primary sensory neurons.
Localization (localized) of VR1 in primary sensory neurons associated with qutenza
3) Confidence 0.81 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11524156 Disease Relevance 0.09 Pain Relevance 0.38
These data suggest that although potentiation of pulmonary chemoreflex response 24h post-acrolein is mediated by TRPV1 and release of substance P, cardiopulmonary inhibition during whole-body acrolein exposure is mediated through other mechanisms.
Localization (release) of TRPV1 in body associated with substance p
4) Confidence 0.81 Published 2008 Journal Respir Physiol Neurobiol Section Abstract Doc Link 17950047 Disease Relevance 0.27 Pain Relevance 0.72
Chemoreflex responses resulting from C-fiber activation are sometimes mediated by TRPV1 and release of substance P.
Localization (release) of TRPV1 associated with c fibre and substance p
5) Confidence 0.81 Published 2008 Journal Respir Physiol Neurobiol Section Abstract Doc Link 17950047 Disease Relevance 0.25 Pain Relevance 0.62
Here, using commercially available specific antibodies to investigate the localization of TRPV1 in the brain of the rat, we report that TRPV1 was expressed in hippocampus, cortex, cerebellum, olfactory bulb, mesencephalon and hindbrain.
Spec (investigate) Localization (localization) of TRPV1 in brain associated with hippocampus
6) Confidence 0.81 Published 2005 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15857679 Disease Relevance 0.18 Pain Relevance 0.44
Immunostaining showed TRPV1 localized in the processes and cytoplasm of pyramidal neurons in CA1-CA3 regions of the hippocampus.
Localization (localized) of TRPV1 in pyramidal neurons associated with pyramidal cell and hippocampus
7) Confidence 0.81 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20592193 Disease Relevance 1.50 Pain Relevance 1.73
Interestingly, immunolabeling showed colocalization of TRPV1, SP, and the panneuronal marker PGP9.5 in the renal pelvis.
Localization (colocalization) of TRPV1 in renal pelvis associated with substance p
8) Confidence 0.81 Published 2008 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 18032552 Disease Relevance 0.05 Pain Relevance 0.90
Capsaicin- and anandamide-induced gastric acid secretion via vanilloid receptor type 1 (TRPV1) in rat brain.
Localization (secretion) of TRPV1 in brain associated with qutenza
9) Confidence 0.81 Published 2005 Journal Brain Res. Section Title Doc Link 15781048 Disease Relevance 0 Pain Relevance 0.99
Capsaicin- and anandamide-induced gastric acid secretion via vanilloid receptor type 1 (TRPV1) in rat brain.
Localization (secretion) of vanilloid receptor type 1 in brain associated with qutenza
10) Confidence 0.81 Published 2005 Journal Brain Res. Section Title Doc Link 15781048 Disease Relevance 0 Pain Relevance 0.99
The main part of the capsaicin-releasable Ca(2+) store was insensitive to thapsigargin, a selective endoplasmic reticulum Ca(2+)-ATPase inhibitor, suggesting that VR1 might be predominantly localized to a thapsigargin-insensitive endoplasmic reticulum Ca(2+) store.
Localization (localized) of VR1 in reticulum associated with qutenza
11) Confidence 0.81 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12454015 Disease Relevance 0.30 Pain Relevance 0.48
Our data show that the level of cholesterol determines the activity and the amount of membrane TRPV1, suggesting that TRPV1 might be localized in cholesterol-rich microdomains in nociceptors.
Localization (localized) of TRPV1 in nociceptors associated with nociceptor
12) Confidence 0.80 Published 2006 Journal Eur. J. Neurosci. Section Abstract Doc Link 16800863 Disease Relevance 0.07 Pain Relevance 0.45
In contrast, there was much less co-localization of TRPV1 and TRPV2 receptors reported for DRG neurons [14].
Localization (localization) of TRPV1 in neurons
13) Confidence 0.80 Published 2006 Journal Mol Pain Section Body Doc Link PMC1647269 Disease Relevance 0.16 Pain Relevance 0.26
The vanilloid receptor 1 (VR1, TRPV1), which is a member of the transient receptor potential (TRP) superfamily, is highly localized on peripheral and central processes of nociceptive afferent fibers.
Localization (localized) of vanilloid receptor 1 associated with nociception
14) Confidence 0.80 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15837818 Disease Relevance 0.50 Pain Relevance 0.60
The vanilloid receptor 1 (VR1, TRPV1), which is a member of the transient receptor potential (TRP) superfamily, is highly localized on peripheral and central processes of nociceptive afferent fibers.
Localization (localized) of VR1 associated with nociception
15) Confidence 0.80 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15837818 Disease Relevance 0.50 Pain Relevance 0.60
The vanilloid receptor 1 (VR1, TRPV1), which is a member of the transient receptor potential (TRP) superfamily, is highly localized on peripheral and central processes of nociceptive afferent fibers.
Localization (localized) of TRPV1 associated with nociception
16) Confidence 0.80 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15837818 Disease Relevance 0.50 Pain Relevance 0.60
Oocytes expressing the inhibitory profile demonstrated colocalization of TRPV1 and VR.5'sv-associated immunostaining in the plasma membrane.
Localization (colocalization) of TRPV1 in plasma
17) Confidence 0.80 Published 2007 Journal Neuroreport Section Abstract Doc Link 17558279 Disease Relevance 0.17 Pain Relevance 0.25
We extended the search for TRPV1-TRPV2 co-localization in the brain, where we detected extensive co-expression of the two receptors in the IV, V and VI layer neurons of the adult rat cerebral cortex.
Localization (co-localization) of TRPV1 in neurons associated with cerebral cortex
18) Confidence 0.80 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16115206 Disease Relevance 0.07 Pain Relevance 0.32
Immunolocalization of VR1 and VRL1 in rat larynx.
Localization (Immunolocalization) of VR1 in larynx
19) Confidence 0.80 Published 2005 Journal Auton Neurosci Section Title Doc Link 15620571 Disease Relevance 0 Pain Relevance 1.07
This colocalization of TRPV1 and TRPM8 in a DRG neuron may be the basis for the paradoxical cold sensation.
Localization (colocalization) of TRPV1 in neuron associated with dorsal root ganglion
20) Confidence 0.80 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15050705 Disease Relevance 0.46 Pain Relevance 0.37

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