INT38755

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Context Info
Confidence 0.44
First Reported 1983
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 2.14
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Aldh1a1) cytoplasm (Aldh1a1)
Anatomy Link Frequency
CPA 2
brain 1
Aldh1a1 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 5 97.08 Very High Very High Very High
aspirin 2 97.04 Very High Very High Very High
cINOD 1 75.00 Quite High
anesthesia 8 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
isoflurane 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 680 99.64 Very High Very High Very High
Colorectal Cancer 128 98.94 Very High Very High Very High
Catalepsy 4 96.40 Very High Very High Very High
Cytomegalovirus Infection 4 95.28 Very High Very High Very High
Pox Virus Infection 4 95.04 Very High Very High Very High
Targeted Disruption 4 85.16 High High
INFLAMMATION 1 75.00 Quite High
Viral Infection 2 71.12 Quite High
Acute Promyelocytic Leukemia 4 62.56 Quite High
Hematological Disease 4 59.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Lentiviral vectors used for these studies contained either an eGFP-Luciferase fusion gene (pLOM65) for clonality studies, or ALDH1A1 (pLOM205) or a control Luciferase (pLOM145) targeted shRNA embedded in the eGFP mRNA; each of which is driven by the CMV promoter.
Regulation (eGFP) of ALDH1A1 associated with cytomegalovirus infection
1) Confidence 0.44 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2413402 Disease Relevance 0.19 Pain Relevance 0
The effect of prostaglandins (PGs) of the A series (A1 and dimethyl PGA2), E1, D2, F2 alpha and PGI2 (prostacyclin) and of inhibitors of PG synthesis (aspirin and indomethacin) on the pathogenicity of vaccinia virus was studied in BALB/c mice.
Regulation (effect) of E1 associated with aspirin and pox virus infection
2) Confidence 0.34 Published 1987 Journal J. Gen. Virol. Section Abstract Doc Link 3819698 Disease Relevance 0.39 Pain Relevance 0.15
To assess clonality using lentiviral insertion site analysis, or introduce shRNA targeting ALDH1A1 or Luciferase, UM-C4 and UM-C6 tumor cells were transduced in vitro over a 3–4 day period.
Regulation (targeting) of ALDH1A1 associated with cancer
3) Confidence 0.26 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2413402 Disease Relevance 0.17 Pain Relevance 0
To determine the importance of ALDH1 to CoCSC tumorigenicity and resistance to CPA, we transduced UM-C6 tumor cells with shRNA targeting ALDH1A1.
Regulation (targeting) of ALDH1A1 in CPA associated with cancer
4) Confidence 0.26 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2413402 Disease Relevance 0.51 Pain Relevance 0
Furthermore, unlike for 4-HC in vitro, DEAB was unable to alter colorectal tumor cell sensitivity to Irinotecan, suggesting that the target of this inhibitor (ALDH1 enzyme activity) plays an important role in resistance to CPA, and resistance to Irinotecan appears to involve another mechanism.
Regulation (target) of ALDH1 in CPA associated with colorectal cancer
5) Confidence 0.26 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2413402 Disease Relevance 0.63 Pain Relevance 0
The effect of prostaglandins (PGs) F1 alpha, F2 alpha, E1, E2, D2, I2, A1, B1 injected into the lateral ventricle of the brain on morphine-induced catalepsy was studied in mice.
Regulation (effect) of E1 in brain associated with catalepsy and morphine
6) Confidence 0.13 Published 1983 Journal Acta Physiol Pol Section Abstract Doc Link 6679984 Disease Relevance 0.25 Pain Relevance 0.40

General Comments

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