INT38760

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Context Info
Confidence 0.39
First Reported 1986
Last Reported 2005
Negated 0
Speculated 1
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 1.82
Pain Relevance 3.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Adra2c) cytoplasm (Adra2c) signal transducer activity (Adra2c)
Anatomy Link Frequency
spinal nerve 1
pituitary 1
dorsal root ganglion 1
Adra2c (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Eae 3 99.68 Very High Very High Very High
Clonidine 16 99.24 Very High Very High Very High
dorsal root ganglion 5 99.22 Very High Very High Very High
Morphine 11 97.58 Very High Very High Very High
nociceptor 2 94.00 High High
Kinase C 6 92.72 High High
Sciatic nerve 2 92.68 High High
Neuropeptide 3 91.12 High High
Neuropathic pain 4 89.24 High High
agonist 2 89.08 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 5 99.22 Very High Very High Very High
Injury 3 97.72 Very High Very High Very High
Nervous System Injury 7 91.32 High High
Neuropathic Pain 7 89.24 High High
Hypersensitivity 1 87.80 High High
Pain 1 83.48 Quite High
Hypertension 2 75.00 Quite High
Nociception 1 68.24 Quite High
Hyperalgesia 1 61.64 Quite High
Heart Rate Under Development 1 35.84 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that clonidine induces the pressor response through activation of central alpha-adrenoceptors, probably the alpha 2 subtype, without an increase in sympatho-adrenomedullary activity.
Spec (probably) Positive_regulation (activation) of alpha 2 subtype associated with clonidine
1) Confidence 0.39 Published 1986 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 3820860 Disease Relevance 0.07 Pain Relevance 0.69
In contrast, alpha2c-adrenergic receptor immunoreactivity was only increased in the spinal nerve ligation model; these increases did not correlate with changes in mechanical sensitivity.
Positive_regulation (increased) of alpha2c-adrenergic in spinal nerve associated with eae
2) Confidence 0.37 Published 1999 Journal Neuroscience Section Abstract Doc Link 10501465 Disease Relevance 1.00 Pain Relevance 0.94
Our previous studies have shown an enhanced activity of the hypothalamus-pituitary-adrenocortical axis response in rats withdrawn from morphine, which results from an increase in the hypothalamic paraventricular nucleus noradrenergic activity that is dependent on alpha-adrenoceptor activation.
Positive_regulation (activation) of alpha-adrenoceptor in pituitary associated with morphine
3) Confidence 0.25 Published 2002 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12323385 Disease Relevance 0 Pain Relevance 0.54
Medium and large injured dorsal root ganglion cells increase TRPV-1, accompanied by increased alpha2C-adrenoceptor co-expression and functional inhibition by clonidine.
Positive_regulation (increased) of alpha2C-adrenoceptor in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion and clonidine
4) Confidence 0.18 Published 2005 Journal Pain Section Title Doc Link 15661448 Disease Relevance 0.74 Pain Relevance 0.86

General Comments

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