INT3877

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Context Info
Confidence 0.57
First Reported 1977
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 30
Total Number 31
Disease Relevance 1.62
Pain Relevance 12.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (MUC7)
Anatomy Link Frequency
plasma 2
spike 1
brain 1
external 1
ciliary 1
MUC7 (Homo sapiens)
Pain Link Frequency Relevance Heat
local anesthetic 27 99.98 Very High Very High Very High
Paracetamol 6 99.98 Very High Very High Very High
tetrodotoxin 14 99.92 Very High Very High Very High
antagonist 25 99.84 Very High Very High Very High
Kinase C 18 99.82 Very High Very High Very High
Opioid 16 99.70 Very High Very High Very High
lidocaine 11 99.70 Very High Very High Very High
aspirin 8 99.66 Very High Very High Very High
Morphine 16 99.52 Very High Very High Very High
opiate 12 99.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 4 95.88 Very High Very High Very High
Pain 4 95.12 Very High Very High Very High
Bordatella Infection 1 94.64 High High
Nociception 2 90.88 High High
Neuropathic Pain 2 89.80 High High
Injury 4 89.20 High High
Appetite Loss 1 84.76 Quite High
Decapitation 4 75.88 Quite High
Erythrocytosis 1 75.00 Quite High
Aging 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Na+,K+-ATPase, but not Mg2+-ATPase was inhibited (30%) by the two amino acids.
Negative_regulation (inhibited) of Mg2
1) Confidence 0.57 Published 2001 Journal Neurochem. Res. Section Abstract Doc Link 11885784 Disease Relevance 0 Pain Relevance 0.29
Na+,K+-ATPase activity, but not Mg2+-ATPase activity, was inhibited by 22-32%.
Negative_regulation (inhibited) of Mg2
2) Confidence 0.57 Published 1998 Journal Neuroreport Section Abstract Doc Link 9665589 Disease Relevance 0.16 Pain Relevance 0.16
Na+,K+-ATPase activity, but not Mg2+-ATPase activity, was inhibited by 20-30%.
Negative_regulation (inhibited) of Mg2
3) Confidence 0.57 Published 1999 Journal Metab Brain Dis Section Abstract Doc Link 10850553 Disease Relevance 0.08 Pain Relevance 0.20
To determine whether kappa-opioid-PKC-dependent decreases in Ca2+-dependent actomyosin Mg2+-ATPase could account for cardioprotection, we subjected hearts to three separate actomyosin ATPase-lowering protocols.
Spec (whether) Negative_regulation (decreases) of Mg2 in hearts associated with kinase c and opioid
4) Confidence 0.42 Published 2003 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 12763745 Disease Relevance 0 Pain Relevance 0.80
There is a good correlation between these K0.5 values and the concentrations of the local anesthetics that inhibit the Ca2(+)-dependent Mg2(+)-ATPase of these membranes.
Negative_regulation (inhibit) of Mg2 associated with local anesthetic
5) Confidence 0.42 Published 1990 Journal J. Neurochem. Section Abstract Doc Link 2164564 Disease Relevance 0 Pain Relevance 0.72
Results showed that in the control group, E-Ca2+, IF, MCV and F-Hb were gradually increased and Ca2+-Mg2+-ATPase and Na+-K+-ATPase activities were decreased.
Negative_regulation (decreased) of Mg2
6) Confidence 0.42 Published 2004 Journal J. Huazhong Univ. Sci. Technol. Med. Sci. Section Abstract Doc Link 15315180 Disease Relevance 0.22 Pain Relevance 0.12
Protein kinase C reduces Mg2+ block of NMDA-receptor channels as a mechanism of modulation.
Negative_regulation (block) of Mg2 associated with kinase c
7) Confidence 0.41 Published 1992 Journal Nature Section Title Doc Link 1373227 Disease Relevance 0.35 Pain Relevance 0.68
When fictive locomotion was induced instead by an activation of kainate receptors a removal of Mg2+ had no effect on the motor pattern.
Negative_regulation (removal) of Mg2
8) Confidence 0.36 Published 1986 Journal Brain Res. Section Abstract Doc Link 2428424 Disease Relevance 0 Pain Relevance 0.33
It was found that the ventral root burst pattern of fictive locomotion was more irregular after removal of Mg2+, particularly at low burst rates.
Negative_regulation (removal) of Mg2 in ventral root
9) Confidence 0.36 Published 1986 Journal Brain Res. Section Abstract Doc Link 2428424 Disease Relevance 0 Pain Relevance 0.36
To evaluate the role of these pacemaker-like oscillations in the generation of locomotion, the motor patterns induced by N-methyl-D,L-aspartate (NMA) before and after removal of Mg2+ were compared.
Negative_regulation (removal) of Mg2
10) Confidence 0.36 Published 1986 Journal Brain Res. Section Abstract Doc Link 2428424 Disease Relevance 0 Pain Relevance 0.36
Both aspirin and paracetamol inhibit Na+K+ ATPase and Mg2+ ATPase in a dose dependent manner.
Negative_regulation (inhibit) of Mg2 associated with aspirin and paracetamol
11) Confidence 0.35 Published 1989 Journal Indian J. Exp. Biol. Section Abstract Doc Link 2561117 Disease Relevance 0 Pain Relevance 0.40
The inhibition of Na+K+ ATPase and Mg2+ ATPase activity which may affect the release and uptake of biogenic amines in CNS, hinders the maturation of human fetal brain.
Negative_regulation (inhibition) of Mg2 in brain
12) Confidence 0.35 Published 1989 Journal Indian J. Exp. Biol. Section Abstract Doc Link 2561117 Disease Relevance 0 Pain Relevance 0.39
The increase of Ca2+ and Mg2+ permeability by dibucaine and by tetracaine is found at concentrations of these drugs that do not produce a noticeable inhibition of the (Ca2+ + Mg2+)-ATPase activity of sarcoplasmic reticulum vesicles.
Negative_regulation (inhibition) of Mg2 in vesicles
13) Confidence 0.21 Published 1987 Journal Biochim. Biophys. Acta Section Abstract Doc Link 3620467 Disease Relevance 0.05 Pain Relevance 0.21
The decrease in Ca2+,Mg2+-ATPase activity seen in SPM 1 + 2 was specifically antagonized by the opiate antagonist naloxone hydrochloride (2 mg/kg, s.c.) when given 15 min before morphine administration.
Negative_regulation (decrease) of Mg2 associated with antagonist, narcan, opiate and morphine
14) Confidence 0.09 Published 1986 Journal J. Neurochem. Section Abstract Doc Link 2944993 Disease Relevance 0 Pain Relevance 1.08
Morphine produced a significant decrease in Ca2+,Mg2+-ATPase activity in synaptosomal fractions (SPM 1 + 2) known to contain a high density of opiate receptors and calmodulin-dependent Ca2+,Mg2+-ATPase.
Negative_regulation (decrease) of Mg2 associated with opiate and morphine
15) Confidence 0.09 Published 1986 Journal J. Neurochem. Section Abstract Doc Link 2944993 Disease Relevance 0 Pain Relevance 0.84
It is suggested that the local anesthetics lidocaine and dibucaine inhibit the Ca2+, Mg2(+)-ATPase of the synaptosomal plasma membrane by disruption of the lipid annulus.
Negative_regulation (inhibit) of Mg2 in plasma associated with lidocaine and local anesthetic
16) Confidence 0.09 Published 1990 Journal J. Neurochem. Section Abstract Doc Link 2138212 Disease Relevance 0 Pain Relevance 0.63
It has been previously shown that local anesthetics inhibit the total Ca2+, Mg2(+)-ATPase activity of synaptosomal plasma membranes.
Negative_regulation (inhibit) of Mg2 in plasma associated with local anesthetic
17) Confidence 0.09 Published 1990 Journal J. Neurochem. Section Abstract Doc Link 2138212 Disease Relevance 0 Pain Relevance 0.31
Spontaneous, low-frequency voltage oscillations (LFOs) were observed in the neurons of rat olfactory bulb upon disinhibition with GABAA antagonists and/or removal of Mg2+ from external saline.
Negative_regulation (removal) of Mg2 in olfactory bulb associated with antagonist
18) Confidence 0.06 Published 2001 Journal Eur. J. Neurosci. Section Abstract Doc Link 11135007 Disease Relevance 0 Pain Relevance 0.17
The presynaptic D,L-AP5-sensitive component was enhanced markedly by the removal of Mg2+ from the superfusate.
Negative_regulation (removal) of Mg2
19) Confidence 0.06 Published 1998 Journal J. Neurophysiol. Section Abstract Doc Link 9535978 Disease Relevance 0 Pain Relevance 0.37
The inhibition of the Mg2(+)-dependent ATPase activities of these membranes was found to be of a noncompetitive type with respect to the substrate ATP-Mg2+, did not significantly shift the Ca2+ dependence of the Ca2+, Mg2(+)-ATPase activity, and occurred in a concentration range of local anesthetics that does not significantly alter the order parameter (fluidity) of these membranes.
Negative_regulation (inhibition) of Mg2 associated with addiction and local anesthetic
20) Confidence 0.06 Published 1990 Journal J. Neurochem. Section Abstract Doc Link 2138212 Disease Relevance 0 Pain Relevance 0.52

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