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Context Info
Confidence 0.51
First Reported 1986
Last Reported 2006
Negated 1
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.10
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (LTC4S) nuclear envelope (LTC4S) small molecule metabolic process (LTC4S)
lyase activity (LTC4S) endoplasmic reticulum (LTC4S) nucleus (LTC4S)
Anatomy Link Frequency
eosinophils 1
LTC4S (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 2 97.20 Very High Very High Very High
cINOD 4 94.72 High High
antagonist 5 89.00 High High
adenocard 3 87.28 High High
aspirin 31 52.16 Quite High
anesthesia 1 25.00 Low Low
Inflammation 5 14.64 Low Low
COX2 2 5.00 Very Low Very Low Very Low
Antihistamine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Asthma 69 99.04 Very High Very High Very High
INFLAMMATION 6 94.00 High High
Rhinitis 3 81.44 Quite High
Urticaria 20 47.20 Quite Low
Pressure And Volume Under Development 42 35.92 Quite Low
Nasal Polyps 2 21.36 Low Low
Chronic Sinusitis 1 20.56 Low Low
Hypersensitivity 4 5.00 Very Low Very Low Very Low
Genetic Predisposition To Disease 2 5.00 Very Low Very Low Very Low
Hypersensitivity Pneumonitis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has been suggested that the activity of the leukotriene C4 synthase gene (LTC4S), a key enzyme in Cys-LT synthesis, is genetically regulated in the pathogenesis of AIA.
Regulation (regulated) of LTC4S associated with asthma
1) Confidence 0.51 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687575 Disease Relevance 1.00 Pain Relevance 0.11
The effect of salmeterol and nimesulide on chemotaxis and synthesis of PAF and LTC4 by human eosinophils.
Regulation (effect) of LTC4 in eosinophils
2) Confidence 0.42 Published 1996 Journal Eur Respir J Suppl Section Title Doc Link 8871060 Disease Relevance 0.09 Pain Relevance 0.21
Aerosol pretreatment with the cyclooxygenase inhibitor indomethacin had no significant effect on either LTC4 or LTD4 dose-response curves; however, at the highest doses of these agonists a notable, nonsignificant inhibition of effects on both Rp and Cdyn was seen.
Neg (no) Regulation (effect) of LTC4 associated with agonist
3) Confidence 0.13 Published 1986 Journal Prostaglandins Section Abstract Doc Link 3823489 Disease Relevance 0 Pain Relevance 0.05

General Comments

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