INT388

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Context Info
Confidence 0.42
First Reported 1979
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.04
Pain Relevance 2.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ace) peptidase activity (Ace) extracellular space (Ace)
extracellular region (Ace) plasma membrane (Ace)
Anatomy Link Frequency
Plasma 2
lung 2
Ace (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 8 99.68 Very High Very High Very High
ketamine 8 99.04 Very High Very High Very High
Enkephalin 8 98.56 Very High Very High Very High
halothane 12 98.20 Very High Very High Very High
Opioid 1 94.56 High High
substance P 8 94.12 High High
antagonist 2 94.04 High High
bradykinin 3 91.84 High High
Inflammatory response 1 90.00 High High
depression 1 52.96 Quite High
Disease Link Frequency Relevance Heat
Disease 73 91.76 High High
INFLAMMATION 1 89.64 High High
Neurodegenerative Disease 4 66.80 Quite High
Syndrome 2 61.48 Quite High
Parkinsonian Disorders 4 57.96 Quite High
Psychosis 1 53.40 Quite High
Depression 1 52.96 Quite High
Dementia 1 52.48 Quite High
Neurological Disease 1 48.72 Quite Low
Hypokinesia 4 47.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An insertion/deletion (I/D) polymorphism of the ACE gene [10] accounting for half the variance in serum ACE levels has been described.
Positive_regulation (variance) of Gene_expression (levels) of serum ACE
1) Confidence 0.42 Published 2008 Journal The Open Neurology Journal Section Body Doc Link PMC2627518 Disease Relevance 1.04 Pain Relevance 0.30
Differences in the rates of conversion of angiotensin I to angiotensin II induced by various anesthetic agents could help explain these previous findings.
Positive_regulation (conversion) of Gene_expression (conversion) of angiotensin I
2) Confidence 0.42 Published 1979 Journal Anesthesiology Section Abstract Doc Link 35043 Disease Relevance 0 Pain Relevance 0.66
Plasma renin activity (rate of angiotensin I generation) does not increase during anesthesia with ketamine, fluroxene, halothane or enflurane in the sodium-repleted rat.
Neg (not) Positive_regulation (increase) of Gene_expression (generation) of angiotensin I in Plasma associated with anesthesia, ketamine and halothane
3) Confidence 0.39 Published 1979 Journal Anesthesiology Section Abstract Doc Link 35043 Disease Relevance 0 Pain Relevance 0.56
Captopril at doses which blocked conversion of angiotensin I to II inhibited the degradation of enkephalins across the lung.
Positive_regulation (conversion) of Gene_expression (conversion) of angiotensin I in lung associated with enkephalin
4) Confidence 0.39 Published 1984 Journal Life Sci. Section Abstract Doc Link 6384711 Disease Relevance 0 Pain Relevance 0.61

General Comments

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