INT3880

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Context Info
Confidence 0.58
First Reported 1975
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 54
Total Number 54
Disease Relevance 37.19
Pain Relevance 4.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Serping1) extracellular region (Serping1) molecular_function (Serping1)
cellular_component (Serping1) biological_process (Serping1)
Anatomy Link Frequency
plasma 8
upper respiratory tract 2
face 2
limbs 1
stem 1
Serping1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
abdominal pain 39 98.92 Very High Very High Very High
bradykinin 44 96.72 Very High Very High Very High
Antihistamine 6 95.32 Very High Very High Very High
anesthesia 5 94.96 High High
corticosteroid 1 93.40 High High
Angina 14 92.32 High High
antagonist 14 76.64 Quite High
Pain 16 74.88 Quite High
b2 receptor 2 72.52 Quite High
imagery 2 71.68 Quite High
Disease Link Frequency Relevance Heat
Hereditary Angioedema 737 100.00 Very High Very High Very High
Infection 115 99.84 Very High Very High Very High
Pressure And Volume Under Development 232 99.72 Very High Very High Very High
Rare Diseases 2 99.68 Very High Very High Very High
Disease 89 99.62 Very High Very High Very High
Laryngeal Edema 24 98.96 Very High Very High Very High
Abdominal Pain 39 98.92 Very High Very High Very High
Asphyxia 2 98.12 Very High Very High Very High
Pancreatitis 2 97.88 Very High Very High Very High
Communicable Diseases 12 97.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hereditary angioedema is caused by a defect in C1 inhibitor activity (C1INH).
Negative_regulation (defect) of C1 inhibitor associated with hereditary angioedema
1) Confidence 0.58 Published 1998 Journal Rev Hosp Clin Fac Med Sao Paulo Section Abstract Doc Link 9659739 Disease Relevance 0.47 Pain Relevance 0.07
Hereditary angioedema is caused by a defect in C1 inhibitor activity (C1INH).
Negative_regulation (defect) of C1INH associated with hereditary angioedema
2) Confidence 0.58 Published 1998 Journal Rev Hosp Clin Fac Med Sao Paulo Section Abstract Doc Link 9659739 Disease Relevance 0.48 Pain Relevance 0.07
A 34-year-old patient with known C1 esterase inhibitor (C1INH) deficiency was managed successfully in our department and her management was a part of a shared care strategy with the medical and anesthetic departments.
Negative_regulation (deficiency) of C1INH
3) Confidence 0.57 Published 2006 Journal Arch. Gynecol. Obstet. Section Abstract Doc Link 16783582 Disease Relevance 0.25 Pain Relevance 0.08
Hereditary angioedema (HAE) is a rare, life-threatening, autosomal dominant disease characterized by recurrent episodes of angioedema, and caused by a deficiency of the plasma protein C1-esterase inhibitor (C1-INH).
Negative_regulation (deficiency) of C1-INH in plasma associated with pressure and volume under development, hereditary angioedema and disease
4) Confidence 0.55 Published 2005 Journal Asian Pac. J. Allergy Immunol. Section Abstract Doc Link 16572743 Disease Relevance 0.88 Pain Relevance 0.14
Hereditary angioedema (HAE) is a rare, life-threatening, autosomal dominant disease characterized by recurrent episodes of angioedema, and caused by a deficiency of the plasma protein C1-esterase inhibitor (C1-INH).
Negative_regulation (deficiency) of C1-esterase inhibitor in plasma associated with pressure and volume under development, hereditary angioedema and disease
5) Confidence 0.55 Published 2005 Journal Asian Pac. J. Allergy Immunol. Section Abstract Doc Link 16572743 Disease Relevance 0.87 Pain Relevance 0.14
A 34-year-old patient with known C1 esterase inhibitor (C1INH) deficiency was managed successfully in our department and her management was a part of a shared care strategy with the medical and anesthetic departments.
Negative_regulation (deficiency) of esterase inhibitor
6) Confidence 0.50 Published 2006 Journal Arch. Gynecol. Obstet. Section Abstract Doc Link 16783582 Disease Relevance 0.25 Pain Relevance 0.08
Pregnancy and C1 esterase inhibitor deficiency: a successful outcome.
Negative_regulation (deficiency) of esterase inhibitor associated with hereditary angioedema
7) Confidence 0.50 Published 2006 Journal Arch. Gynecol. Obstet. Section Title Doc Link 16783582 Disease Relevance 0.28 Pain Relevance 0.08
BACKGROUND: Hereditary angioedema (HAE) is an autosomal dominant disease characterized by recurrent angioedema episodes caused by a quantitative or functional defect of the plasma protein C1 esterase inhibitor (C1-INH).
Negative_regulation (defect) of C1-INH in plasma associated with pressure and volume under development, hereditary angioedema and disease
8) Confidence 0.49 Published 2008 Journal Int. Arch. Allergy Immunol. Section Abstract Doc Link 18535392 Disease Relevance 0.66 Pain Relevance 0.10
A diagnosis of hereditary angioedema was made based on the patient's and family's history and on decreased levels of C1 INH and complement component 4.
Negative_regulation (decreased) of C1 INH
9) Confidence 0.48 Published 1996 Journal J Reprod Med Section Body Doc Link 8829070 Disease Relevance 0 Pain Relevance 0
These led to the unusual diagnosis of hereditary angioedema due to deficiency of C1 esterase inhibitor (C1-INH).
Negative_regulation (deficiency) of esterase inhibitor associated with hereditary angioedema
10) Confidence 0.44 Published 1991 Journal Minerva Pediatr. Section Abstract Doc Link 1842037 Disease Relevance 0.60 Pain Relevance 0.17
BACKGROUND: Hereditary angioedema (HAE) is an autosomal dominant disease characterized by recurrent angioedema episodes caused by a quantitative or functional defect of the plasma protein C1 esterase inhibitor (C1-INH).
Negative_regulation (defect) of esterase inhibitor in plasma associated with pressure and volume under development, hereditary angioedema and disease
11) Confidence 0.43 Published 2008 Journal Int. Arch. Allergy Immunol. Section Abstract Doc Link 18535392 Disease Relevance 0.66 Pain Relevance 0.10
Hereditary angioneurotic oedema is a rare complement-related disorder (C1-esterase-inhibitor deficiency) characterised by recurrent episodic swelling of the limbs, face, gastrointestinal tract, or airways.
Negative_regulation (deficiency) of C1-esterase-inhibitor in face associated with pressure and volume under development and hereditary angioedema
12) Confidence 0.43 Published 1987 Journal Ultraschall Med Section Abstract Doc Link 3324342 Disease Relevance 0.64 Pain Relevance 0.11
In all HAE-patients the C1-INH serum-level was diminished, and also in two children who have yet had no complaints.
Negative_regulation (diminished) of C1-INH associated with pressure and volume under development
13) Confidence 0.42 Published 1984 Journal J Laryngol Otol Section Abstract Doc Link 6693805 Disease Relevance 0.94 Pain Relevance 0
Hereditary angioedema (HAE) is caused by a deficiency in C1 esterase-inhibitor (C1-INH) and is characterised by skin swelling, abdominal pain and episodes of upper respiratory tract obstruction.
Negative_regulation (deficiency) of C1-INH in upper respiratory tract associated with pressure and volume under development, abdominal pain and hereditary angioedema
14) Confidence 0.41 Published 2005 Journal Int. J. Clin. Pract. Section Abstract Doc Link 15857357 Disease Relevance 0.96 Pain Relevance 0.10
Hereditary deficiency of C1-esterase inhibitor (C1-INH) which clinically manifests as hereditary angioedema is a rare disorder.
Negative_regulation (deficiency) of C1-INH associated with hereditary angioedema
15) Confidence 0.41 Published 2002 Journal Klin Padiatr Section Abstract Doc Link 11823949 Disease Relevance 0.25 Pain Relevance 0.15
Hereditary deficiency of C1-esterase inhibitor (C1-INH) which clinically manifests as hereditary angioedema is a rare disorder.
Negative_regulation (deficiency) of C1-esterase inhibitor associated with hereditary angioedema
16) Confidence 0.41 Published 2002 Journal Klin Padiatr Section Abstract Doc Link 11823949 Disease Relevance 0.25 Pain Relevance 0.15
A multicentre, retrospective study of hereditary deficiency of C1-esterase inhibitor (C1-INH) function, a deficiency which clinically manifests as hereditary angioedema (HAE), was performed in six centres in Germany, Austria and Switzerland. 242 individuals were registered with proven functional or quantitative deficiency of C1-INH who belonged to kindered with disease manifestation in 2 to 6 generations.
Negative_regulation (deficiency) of C1-esterase inhibitor associated with hereditary angioedema and disease
17) Confidence 0.41 Published 1998 Journal Hautarzt Section Abstract Doc Link 9551333 Disease Relevance 0.36 Pain Relevance 0
A multicentre, retrospective study of hereditary deficiency of C1-esterase inhibitor (C1-INH) function, a deficiency which clinically manifests as hereditary angioedema (HAE), was performed in six centres in Germany, Austria and Switzerland. 242 individuals were registered with proven functional or quantitative deficiency of C1-INH who belonged to kindered with disease manifestation in 2 to 6 generations.
Negative_regulation (deficiency) of C1-INH associated with hereditary angioedema and disease
18) Confidence 0.41 Published 1998 Journal Hautarzt Section Abstract Doc Link 9551333 Disease Relevance 0.37 Pain Relevance 0
A multicentre, retrospective study of hereditary deficiency of C1-esterase inhibitor (C1-INH) function, a deficiency which clinically manifests as hereditary angioedema (HAE), was performed in six centres in Germany, Austria and Switzerland. 242 individuals were registered with proven functional or quantitative deficiency of C1-INH who belonged to kindered with disease manifestation in 2 to 6 generations.
Negative_regulation (deficiency) of C1-INH associated with hereditary angioedema and disease
19) Confidence 0.41 Published 1998 Journal Hautarzt Section Abstract Doc Link 9551333 Disease Relevance 0.36 Pain Relevance 0
Hereditary angioedema (HAE) is a rare disease resulting from deficiency of complement 1 esterase inhibitor (C1-INH).
Negative_regulation (deficiency) of C1-INH associated with rare diseases and hereditary angioedema
20) Confidence 0.39 Published 2000 Journal Turk. J. Pediatr. Section Abstract Doc Link 11105624 Disease Relevance 0.93 Pain Relevance 0.06

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