INT3881

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.41
First Reported 1977
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 21
Total Number 22
Disease Relevance 20.00
Pain Relevance 3.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (F13A1) transferase activity, transferring acyl groups (F13A1) cytoplasm (F13A1)
Anatomy Link Frequency
plasma 9
platelet 9
neutrophil 2
F13A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 19 100.00 Very High Very High Very High
depression 5 95.60 Very High Very High Very High
headache 2 94.08 High High
Arthritis 1 91.52 High High
Pain 19 90.48 High High
backache 1 90.48 High High
cINOD 11 88.72 High High
cytokine 6 88.52 High High
Inflammation 14 88.12 High High
cva 51 87.60 High High
Disease Link Frequency Relevance Heat
Cv General 3 Under Development 54 100.00 Very High Very High Very High
Myocardial Infarction 27 100.00 Very High Very High Very High
Necrosis 18 100.00 Very High Very High Very High
Obstructive Sleep Apnea 163 99.84 Very High Very High Very High
Hypocalcemia 8 99.84 Very High Very High Very High
Thrombosis 22 99.32 Very High Very High Very High
Injury 221 99.24 Very High Very High Very High
Eosinophilia 1 99.20 Very High Very High Very High
Thrombocytopenia 54 99.18 Very High Very High Very High
Acidosis 8 98.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although elevated levels of fibrin degradation products were found in most patients, disseminated intravascular coagulation could not be diagnosed.
Positive_regulation (levels) of Protein_catabolism (degradation) of fibrin associated with thrombosis
1) Confidence 0.41 Published 1980 Journal Trop Geogr Med Section Abstract Doc Link 7423600 Disease Relevance 1.14 Pain Relevance 0.17
Eosinophilia, monocytosis, mild hypocalcemia and an increase in fibrin degradation products were seen in a few patients.
Positive_regulation (increase) of Protein_catabolism (degradation) of fibrin associated with hypocalcemia and eosinophilia
2) Confidence 0.38 Published 1987 Journal Cancer Chemother. Pharmacol. Section Abstract Doc Link 3664933 Disease Relevance 1.76 Pain Relevance 0.18
These findings include the nephrotic syndrome, great variability in proteinuria and glomerular filtration rate, pulmonary embolization, sterile pyuria, hematuria, hyperchloremic acidosis, decreased renal tubular threshold for glucose and increased fibrin degradation products.
Positive_regulation (increased) of Protein_catabolism (degradation) of fibrin associated with acidosis, pyuria, proteinuria, hematuria and disorder of lipid metabolism
3) Confidence 0.38 Published 1977 Journal Am. J. Med. Section Abstract Doc Link 900143 Disease Relevance 0.73 Pain Relevance 0
Plasma levels of peptide B beta, a product of fibrin degradation by human neutrophil elastase, were approximately 15-fold higher (p less than 0.001) in patients with unstable angina or AMI (588 +/- 171 pmol/l, mean +/- SEM) compared with those in patients with stable angina (37 +/- 25 pmol/l) or control subjects (40 +/- 22 pmol/l), confirming intense in vivo neutrophil activation.
Positive_regulation (confirming) of Protein_catabolism (degradation) of fibrin in neutrophil associated with angina and myocardial infarction
4) Confidence 0.19 Published 1989 Journal Circulation Section Abstract Doc Link 2537159 Disease Relevance 1.60 Pain Relevance 0.80
If a patient has increased fibrin degradation products due to disseminated intravascular coagulation and/or hyperfibrinolysis, this will interfere with platelet function and a higher threshold of 75 × 109/l has been suggested by consensus groups [275,276].
Positive_regulation (increased) of Protein_catabolism (degradation) of fibrin in platelet associated with thrombosis
5) Confidence 0.14 Published 2010 Journal Crit Care Section Body Doc Link PMC2887168 Disease Relevance 0.99 Pain Relevance 0.03
A progressive decrease in blood platelet content, together with an elevation of fibrin degradation products (D-dimer: 1144 ng/mL) suggested activation of fibrinolysis and possible disseminated intravascular coagulation.
Positive_regulation (elevation) of Protein_catabolism (degradation) of fibrin in blood platelet associated with disseminated intravascular coagulation
6) Confidence 0.08 Published 2005 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661629 Disease Relevance 0.88 Pain Relevance 0
Elevated plasma D-dimer levels indicate increased plasmin degradation of cross-linked fibrin, and are therefore an indirect indication of increased thrombin activity and fibrin formation.
Positive_regulation (increased) of Protein_catabolism (degradation) of fibrin in plasma
7) Confidence 0.08 Published 1989 Journal Haemostasis Section Abstract Doc Link 2731776 Disease Relevance 0.27 Pain Relevance 0.20
Coagulation profile revealed decreased platelets, plasma coagulation factors and fibrinogen in association with elevated fibrin degradation products.
Positive_regulation (elevated) of Protein_catabolism (degradation) of fibrin in platelets
8) Confidence 0.06 Published 1999 Journal Anaesth Intensive Care Section Abstract Doc Link 10389563 Disease Relevance 0.51 Pain Relevance 0.17
Elevated plasma D-dimer levels indicate increased plasmin degradation of cross-linked fibrin, and are therefore an indirect indication of increased thrombin activity and fibrin formation.
Positive_regulation (increased) of Protein_catabolism (degradation) of fibrin in plasma
9) Confidence 0.05 Published 1989 Journal Haemostasis Section Abstract Doc Link 2731776 Disease Relevance 0.27 Pain Relevance 0.20
Impaired fibrin degradation, due to high circulating levels of plasminogen activator inhibitor type-1, further enhances intravascular fibrin deposition (Figure 4).
Positive_regulation (enhances) of Protein_catabolism (degradation) of fibrin
10) Confidence 0.04 Published 2006 Journal Crit Care Section Body Doc Link PMC1750988 Disease Relevance 0.93 Pain Relevance 0.17
Impaired fibrin degradation, due to high circulating levels of PAI-1, contributes to enhanced intravascular fibrin deposition [1].
Positive_regulation (contributes) of Protein_catabolism (degradation) of fibrin
11) Confidence 0.04 Published 2006 Journal Thromb J Section Body Doc Link PMC1533804 Disease Relevance 0.85 Pain Relevance 0.03
Patients with DIC have a low or rapidly decreasing platelet count, prolonged coagulation tests, low plasma levels of coagulation factors and inhibitors, and increased markers of fibrin formation and/or degradation, such as D-dimer or fibrin degradation products [32].
Positive_regulation (increased) of Protein_catabolism (degradation) of fibrin in platelet associated with disseminated intravascular coagulation
12) Confidence 0.04 Published 2006 Journal Crit Care Section Body Doc Link PMC1750988 Disease Relevance 0.97 Pain Relevance 0.15
Coagulation profile revealed decreased platelets, plasma coagulation factors and fibrinogen in association with elevated fibrin degradation products.
Positive_regulation (elevated) of in plasma Protein_catabolism (degradation) of fibrin in platelets
13) Confidence 0.02 Published 1999 Journal Anaesth Intensive Care Section Abstract Doc Link 10389563 Disease Relevance 0.51 Pain Relevance 0.17
Hematologic manifestations consisted of leukocytosis with a left shift, thrombocytopenia, prolonged partial thromboplastin time, increased fibrin degradation products, and positive protamine sulfate test.
Spec (partial) Positive_regulation (increased) of Protein_catabolism (degradation) of fibrin associated with leukocytosis and thrombocytopenia
14) Confidence 0.02 Published 1981 Journal Clin. Toxicol. Section Abstract Doc Link 7237964 Disease Relevance 1.67 Pain Relevance 0.08
It promotes degradation of the fibrin only at the clot surface and it is not associated with systemic fibrinolysis. rTPA has been effectively used in the past in traumatic hyphema [1], fibrinous effusion after cataract surgery in adults [2], severe post cataract fibrinous membrane in pediatric groups [3], glaucoma surgery [4, 5 ] and subretinal hemorrhage [6].
Positive_regulation (promotes) of Protein_catabolism (degradation) of fibrin associated with ocular injury, glaucoma, cva and cataract
15) Confidence 0.02 Published 2009 Journal The Open Ophthalmology Journal Section Body Doc Link PMC2771269 Disease Relevance 1.81 Pain Relevance 0.21
D-dimer, a degradation product of fibrin, is elevated in OSA indicating increased fibrinolytic activity with higher levels seen in patients with greater hypoxia (Shitrit et al 2005).
Positive_regulation (elevated) of Protein_catabolism (degradation) of fibrin associated with hypoxia and obstructive sleep apnea
16) Confidence 0.01 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671821 Disease Relevance 1.15 Pain Relevance 0.09
The patient had depressed antithrombin III activity and abnormally high concentrations of both fibrin degradation products and thrombin-antithrombin complexes.
Positive_regulation (concentrations) of Protein_catabolism (degradation) of fibrin
17) Confidence 0.01 Published 1998 Journal Clin. Rheumatol. Section Abstract Doc Link 9694066 Disease Relevance 0.75 Pain Relevance 0.34
Blacks displayed significantly lower nadir fibrinogen levels (0.57 +/- 0.62 versus 1.3 +/- 0.76 g/l, p less than 0.0001), greater delta fibrinogen (baseline-nadir) (2.7 +/- 1.1 versus 1.7 +/- 1.1 g/l, p less than 0.0001), and increased peak levels of fibrin(ogen) degradation products (837 +/- 865 versus 245 +/- 475 micrograms/ml, p less than 0.0001). rt-PA antigen levels tended to be higher in blacks than in whites (2.8 +/- 2.2 versus 2.2 +/- 3.2 micrograms/ml [p = 0.10] at the peak and 1.6 +/- 1.3 versus 0.99 +/- 1.4 micrograms/ml [p = 0.06] at the end of the maintenance infusion).
Positive_regulation (increased) of Protein_catabolism (degradation) of fibrin
18) Confidence 0.01 Published 1991 Journal Circulation Section Abstract Doc Link 1898641 Disease Relevance 0.31 Pain Relevance 0.08
Physical exertion induces thrombin formation and fibrin degradation in patients with peripheral atherosclerosis.
Positive_regulation (induces) of Protein_catabolism (degradation) of fibrin associated with atherosclerosis
19) Confidence 0.00 Published 1998 Journal Arterioscler. Thromb. Vasc. Biol. Section Title Doc Link 9484989 Disease Relevance 0.81 Pain Relevance 0.12
Cross-linked fibrin degradation products (D-dimer) were also high just after the onset of BMN and continued to be high for 3 weeks after the onset.
Positive_regulation (high) of Protein_catabolism (degradation) of fibrin associated with necrosis
20) Confidence 0.00 Published 2002 Journal Am. J. Hematol. Section Abstract Doc Link 12111773 Disease Relevance 2.05 Pain Relevance 0.09

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox