INT38828

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Context Info
Confidence 0.44
First Reported 1987
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 14
Total Number 19
Disease Relevance 7.27
Pain Relevance 0.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (STS) nuclear envelope (STS) small molecule metabolic process (STS)
Golgi apparatus (STS) endoplasmic reticulum (STS) plasma membrane (STS)
Anatomy Link Frequency
plasma 1
T-47D 1
MCF-7 1
STS (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 2 99.42 Very High Very High Very High
Pain 4 99.18 Very High Very High Very High
addiction 17 96.56 Very High Very High Very High
amygdala 71 89.44 High High
palliative 1 75.44 Quite High
lidocaine 3 71.12 Quite High
alcohol 6 70.24 Quite High
cytokine 14 65.80 Quite High
anesthesia 1 25.00 Low Low
abdominal pain 6 23.48 Low Low
Disease Link Frequency Relevance Heat
Anxiety Disorder 3 99.60 Very High Very High Very High
Infection 169 99.54 Very High Very High Very High
Breast Cancer 18 99.46 Very High Very High Very High
Depression 2 99.42 Very High Very High Very High
Disease 40 99.32 Very High Very High Very High
Pain 3 99.18 Very High Very High Very High
Apoptosis 816 98.62 Very High Very High Very High
Sprains And Strains 109 97.16 Very High Very High Very High
Advanced Or Metastatic Breast Cancer 2 96.88 Very High Very High Very High
Toxicity 1 92.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Estradiol inhibits the estrone sulfatase activity in normal and cancerous human breast tissues.
Negative_regulation (inhibits) of estrone sulfatase
1) Confidence 0.44 Published 2007 Journal J. Steroid Biochem. Mol. Biol. Section Title Doc Link 17481887 Disease Relevance 0.60 Pain Relevance 0.07
In previous studies, it was demonstrated that in isolated MCF-7 and T-47D breast cancer cell lines, estradiol can block estrone sulfatase activity.
Negative_regulation (block) of estrone sulfatase in T-47D associated with breast cancer
2) Confidence 0.38 Published 2007 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 17481887 Disease Relevance 0.53 Pain Relevance 0.07
Figure 6 shows that within 100 ms after image onset, emotion separation was already established in STS, AMY and MPFC.
Negative_regulation (established) of STS
3) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842434 Disease Relevance 0 Pain Relevance 0.12
New inhibitors of aromatase and estrone sulfatase have been reported.
Negative_regulation (inhibitors) of estrone sulfatase
4) Confidence 0.29 Published 1993 Journal Curr Opin Oncol Section Abstract Doc Link 8305549 Disease Relevance 0.40 Pain Relevance 0.08
Basal gonadotropins and their responses to GnRH-STs and E2 levels were suppressed.
Negative_regulation (suppressed) of STs
5) Confidence 0.18 Published 2005 Journal Pediatrics Section Body Doc Link 16322137 Disease Relevance 0.05 Pain Relevance 0
However, there are many other factors (balancing ability, sensorimotor condition, pain, depression, anxiety and vitality) that limit STS performance.
Negative_regulation (limit) of STS associated with pain, depression and anxiety disorder
6) Confidence 0.16 Published 2007 Journal Biomed Eng Online Section Body Doc Link PMC1929086 Disease Relevance 0.30 Pain Relevance 0.15
In previous studies, it was demonstrated that in isolated MCF-7 and T-47D breast cancer cell lines, estradiol can block estrone sulfatase activity.
Negative_regulation (block) of estrone sulfatase in MCF-7 associated with breast cancer
7) Confidence 0.13 Published 2007 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 17481887 Disease Relevance 0.53 Pain Relevance 0.07
The common gap in both physical contigs indicates either a lack of STS markers in this region or an under-representation of clones even though two libraries were used in our study, or both.
Negative_regulation (lack) of STS
8) Confidence 0.13 Published 2002 Journal BMC Genomics Section Body Doc Link PMC122098 Disease Relevance 0.10 Pain Relevance 0
Although difficult to test, the finding that ST34 co-existed in the environment with a large number of other STs but caused most disease would be supportive of this hypothesis.
Negative_regulation (number) of STs associated with disease
9) Confidence 0.08 Published 2007 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2041815 Disease Relevance 0.55 Pain Relevance 0
Based on these results, we chose to examine uninfected and infected cells in the presence and absence of STS using the strategy outlined in Figure 2.
Spec (examine) Negative_regulation (absence) of STS
10) Confidence 0.03 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.28 Pain Relevance 0
Thus, the array results demonstrated that there were few significant differences between the two conditions and suggested that the bacteria induce the same pro-survival state in infected cells regardless of the presence or absence of STS.
Negative_regulation (absence) of STS
11) Confidence 0.03 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.36 Pain Relevance 0
Therefore, the goal of this paper was to identify the changes in apoptosis-specific genes due to S. flexneri invasion both in the presence and absence of STS.
Negative_regulation (absence) of STS associated with apoptosis
12) Confidence 0.03 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 1.03 Pain Relevance 0.03
The identification of the Shigella proteins required for the inhibition of apoptosis and the mechanism by which the proteins inhibit apoptosis will help define which changes in eukaryotic gene expression are relevant for STS inhibition.
Negative_regulation (inhibition) of STS associated with apoptosis
13) Confidence 0.03 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.55 Pain Relevance 0
In both the presence and absence of STS, 90 percent infection was achieved as previously demonstrated [2].
Negative_regulation (absence) of STS associated with infection
14) Confidence 0.03 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.64 Pain Relevance 0.04
B due to infection, or might be a direct effect of STS.
Negative_regulation (effect) of STS associated with infection
15) Confidence 0.03 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.44 Pain Relevance 0
We noted a large number of STs and high allelic diversity at all loci within the 89 O. tsutsugamushi strains characterized by MLST.
Negative_regulation (number) of STs associated with sprains and strains
16) Confidence 0.02 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2907413 Disease Relevance 0.91 Pain Relevance 0
stand for the
rate constants for GTN-induced thiolate oxidation, DTT-reversible disulfide
formation, GTN-induced DTT-irreversible inactivation, and DTT-exacted
reduction of the ES-S and ES·
enzyme states, respectively). 
Negative_regulation (reduction) of ES
17) Confidence 0.01 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2576553 Disease Relevance 0 Pain Relevance 0.03
stand for the
rate constants for GTN-induced thiolate oxidation, DTT-reversible disulfide
formation, GTN-induced DTT-irreversible inactivation, and DTT-exacted
reduction of the ES-S and ES·
enzyme states, respectively). 
Negative_regulation (reduction) of ES
18) Confidence 0.01 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2576553 Disease Relevance 0 Pain Relevance 0.03
The use of atracurium during anaesthesia for abdominal hysterectomy in a 37-year-old patient with homozygous plasma cholinesterase [EsEs] deficiency is described.
Negative_regulation (deficiency) of EsEs in plasma
19) Confidence 0.00 Published 1987 Journal Can J Anaesth Section Abstract Doc Link 3829287 Disease Relevance 0 Pain Relevance 0

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