INT38834

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Context Info
Confidence 0.42
First Reported 1985
Last Reported 2007
Negated 1
Speculated 1
Reported most in Body
Documents 2
Total Number 9
Disease Relevance 4.18
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (PPY)
Anatomy Link Frequency
hepatocyte 2
skin 2
PPY (Homo sapiens)
Pain Link Frequency Relevance Heat
Bile 2 96.72 Very High Very High Very High
palliative 7 96.44 Very High Very High Very High
Chronic pancreatitis 1 91.76 High High
Pain 15 90.72 High High
diabetic neuropathy 1 86.64 High High
Bioavailability 42 84.56 Quite High
alcohol 21 36.08 Quite Low
addiction 14 5.00 Very Low Very Low Very Low
transdermal 7 5.00 Very Low Very Low Very Low
Glutamate 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anaemia 4 100.00 Very High Very High Very High
Pancreatic Cancer 1 99.90 Very High Very High Very High
Cancer 126 99.84 Very High Very High Very High
Phototoxic Dermatitis 7 98.98 Very High Very High Very High
Keloid Scars 7 97.84 Very High Very High Very High
Sprains And Strains 2 93.88 High High
Exocrine Pancreatic Insufficiency 1 93.60 High High
Liver Failure 2 92.92 High High
Jaundice 1 92.16 High High
Pancreatitis 1 91.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Endocrine active pancreatic tumors may cause highly increased PP levels together with other hormones and elevated serum PP levels may be used as a diagnostic indication in such rare cases.
Spec (may) Positive_regulation (cause) of Positive_regulation (increased) of PP associated with pancreatic cancer
1) Confidence 0.42 Published 1985 Journal Acta Med. Austriaca Section Abstract Doc Link 3832746 Disease Relevance 0.61 Pain Relevance 0.17
Compared with BALB/cByJCrl, C57BL/6JCrl mice developed moderate but increasing anemia and intense liver accumulation of PP with severe hepatocyte damage and loss.
Positive_regulation (increasing) of Positive_regulation (accumulation) of PP in hepatocyte associated with anaemia
2) Confidence 0.23 Published 2005 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 15677551 Disease Relevance 1.46 Pain Relevance 0.13
Cell culture studies have demonstrated that aliphatic straight chain ALA esters, up as far as the hexyl ester in the homologous series, induce higher levels of PpIX in neoplastic cells more rapidly than the parent compound,62,63,80,82,109,129,130 presumably due to their non-requirement for a saturable active transport mechanism.
Positive_regulation (induce) of Positive_regulation (levels) of PpIX
3) Confidence 0.01 Published 2007 Journal Perspectives in Medicinal Chemistry Section Body Doc Link PMC2754918 Disease Relevance 0.08 Pain Relevance 0
However, as discussed previously, these characteristics might be advantageously used to further increase the selectivity of ALA-induced PpIX accumulation by targeting specific proteases found in abundance in some tumors.86,113,114
Positive_regulation (increase) of Positive_regulation (accumulation) of PpIX associated with cancer
4) Confidence 0.01 Published 2007 Journal Perspectives in Medicinal Chemistry Section Body Doc Link PMC2754918 Disease Relevance 0.21 Pain Relevance 0
Such dendron and dendrimers moieties exhibit the enhanced permeability and retention effect in tumours.88 This may enhance tumour-specific ALA delivery and lead to increased specificity of PpIX accumulation in tumour cells.


Positive_regulation (increased) of Positive_regulation (accumulation) of PpIX associated with cancer
5) Confidence 0.01 Published 2007 Journal Perspectives in Medicinal Chemistry Section Body Doc Link PMC2754918 Disease Relevance 0.42 Pain Relevance 0.04
While each of these approaches leads to PpIX accumulation in the target cells, each is associated with significant difficulties.
Positive_regulation (leads) of Positive_regulation (accumulation) of PpIX
6) Confidence 0.01 Published 2007 Journal Perspectives in Medicinal Chemistry Section Body Doc Link PMC2754918 Disease Relevance 0.33 Pain Relevance 0.08
PDT using topically applied ALA, in addition to producing successful therapeutic outcomes with excellent tissue preservation and no scarring, does not give rise to prolonged cutaneous phototoxicity.38,55 Thus, ALA-PDT can be repeated often without causing accumulation of PpIX in normal skin.11 This is particularly important when the aim of treatment is primarily palliative.
Neg (without) Positive_regulation (causing) of Positive_regulation (accumulation) of PpIX in skin associated with phototoxic dermatitis, keloid scars and palliative
7) Confidence 0.01 Published 2007 Journal Perspectives in Medicinal Chemistry Section Body Doc Link PMC2754918 Disease Relevance 0.59 Pain Relevance 0.10
However, as discussed previously, these characteristics might be advantageously used to further increase the selectivity of ALA-induced PpIX accumulation by targeting specific proteases found in abundance in some tumors.86,113,114
Positive_regulation (induced) of Positive_regulation (accumulation) of PpIX associated with cancer
8) Confidence 0.01 Published 2007 Journal Perspectives in Medicinal Chemistry Section Body Doc Link PMC2754918 Disease Relevance 0.20 Pain Relevance 0
Chemical modification of the parent ALA molecule is aimed at improving the efficiency of ALA-based PDT by increasing ALA delivery, enhancing PpIX accumulation and reducing side effects.
Positive_regulation (enhancing) of Positive_regulation (accumulation) of PpIX
9) Confidence 0.01 Published 2007 Journal Perspectives in Medicinal Chemistry Section Body Doc Link PMC2754918 Disease Relevance 0.28 Pain Relevance 0.09

General Comments

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