INT38859

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Context Info
Confidence 0.75
First Reported 1985
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 19
Disease Relevance 12.98
Pain Relevance 4.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (SGSM3) cell cycle (SGSM3) cytoplasm (SGSM3)
Anatomy Link Frequency
blood 2
plasma 1
lung 1
SGSM3 (Homo sapiens)
Pain Link Frequency Relevance Heat
cva 272 100.00 Very High Very High Very High
Morphine 6 99.80 Very High Very High Very High
methadone 7 99.54 Very High Very High Very High
Inflammation 15 99.34 Very High Very High Very High
Pain 22 98.28 Very High Very High Very High
Nav1.9 2 97.40 Very High Very High Very High
nav1.8 2 96.92 Very High Very High Very High
Nav1.7 2 96.60 Very High Very High Very High
Nav1.6 2 96.28 Very High Very High Very High
nav1.3 2 95.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Paratuberculosis 480 100.00 Very High Very High Very High
Cv General 3 Under Development 266 100.00 Very High Very High Very High
Diabetes Mellitus 522 99.84 Very High Very High Very High
Fever 4 99.52 Very High Very High Very High
INFLAMMATION 17 99.34 Very High Very High Very High
Neuroma 10 98.64 Very High Very High Very High
Injury 25 97.88 Very High Very High Very High
Small Cell Lung Cancer 5 97.16 Very High Very High Very High
Stress 9 97.04 Very High Very High Very High
Small Cell Lung Carcinoma 1 96.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This was accompanied by a decrease in the expressions of SOS and phosphorylated MAP kinases, ERK1 and ERK2, but not FAK or Grab2.
Gene_expression (expressions) of MAP
1) Confidence 0.75 Published 2004 Journal Med. Sci. Monit. Section Body Doc Link 15173663 Disease Relevance 0 Pain Relevance 0
The variations in CSF and coronary resistance (MAP/CSF) were also significantly different after administration of molsidomine, with better metabolic regulation of the coronary circulation.
Gene_expression (resistance) of MAP
2) Confidence 0.65 Published 1985 Journal Am. Heart J. Section Abstract Doc Link 3838404 Disease Relevance 0.18 Pain Relevance 0.23
The targets comprised cyclo-oxygenases 1 & 2 (COX), p38 MAP kinase (p38), c-Jun terminal-NH(2) kinase (JNK) and type 4 cAMP-specific phosphodiesterase (PDE4).
Gene_expression (kinase) of MAP
3) Confidence 0.65 Published 2010 Journal Bioorg. Med. Chem. Section Abstract Doc Link 20188577 Disease Relevance 0.09 Pain Relevance 0.04
Resting PPS, HR, MAP, PRP and presence of a noxious withdrawal reflex (NWR) were recorded in 181 out-clinic patients.
Gene_expression (Resting) of MAP
4) Confidence 0.65 Published 2009 Journal Scand. J. Clin. Lab. Invest. Section Body Doc Link 19544223 Disease Relevance 0.09 Pain Relevance 0
Resting PPS, HR, MAP, PRP and presence of a noxious withdrawal reflex (NWR) were recorded in 181 out-clinic patients.
Gene_expression (recorded) of MAP
5) Confidence 0.65 Published 2009 Journal Scand. J. Clin. Lab. Invest. Section Body Doc Link 19544223 Disease Relevance 0.09 Pain Relevance 0
MAIN RESULTS: All postintubation values of SBP, DBP, MAP, and HR were significantly lower in the lidocaine group than the control group (P < 0.01).
Gene_expression (values) of MAP
6) Confidence 0.65 Published 2009 Journal J Clin Anesth Section Body Doc Link 19329013 Disease Relevance 0 Pain Relevance 0
Exposure of 'variant' small cell lung carcinoma (SCLC) and non-SCLC cells, which secrete low concentrations (< 0.01 pmol/mg protein) of bombesin, to nanomolar concentrations of methadone resulted in increased levels of mitogen-activated protein (MAP) kinase phosphatases and inactivation of MAP kinase, suppression of the bcl-2 protein, and induction of apoptosis.
Gene_expression (levels) of MAP in lung associated with small cell lung carcinoma, methadone, apoptosis and small cell lung cancer
7) Confidence 0.65 Published 1999 Journal Cancer Lett. Section Abstract Doc Link 10355747 Disease Relevance 0.99 Pain Relevance 0.93
Acting on a separate anti-inflammatory pathway, calcitriol induces the expression of mitogen-activated protein kinase phosphatase 5 (MKP5), a member of a family of phosphatases that are negative regulators of MAP kinases, causing the selective dephosphorylation and inactivation of the stress-activated protein kinase p38.
Gene_expression (expression) of MAP associated with stress and inflammation
8) Confidence 0.58 Published 2007 Journal J. Bone Miner. Res. Section Abstract Doc Link 18290727 Disease Relevance 1.22 Pain Relevance 0.45
The blood levels of MAP and MOR were toxic and putatively lethal, respectively, although hyperthermia is a known cause of intoxication due to MAP rather than MOR.
Gene_expression (levels) of MAP in blood associated with fever, poisoning and morphine
9) Confidence 0.58 Published 2003 Journal J. Forensic Sci. Section Abstract Doc Link 14535689 Disease Relevance 0.38 Pain Relevance 0.55
INTERPRETATION: These results demonstrate that multiple sodium channel isoforms (Nav1.3, Nav1.7, and Nav1.8), as well as activated p38 and ERK1/2 MAP kinases, are expressed in painful human neuromas, indicating that these molecules merit study as possible therapeutic targets for the treatment of pain associated with traumatic neuromas.


Gene_expression (expressed) of MAP
10) Confidence 0.18 Published 2008 Journal Ann. Neurol. Section Body Doc Link 19107992 Disease Relevance 0.14 Pain Relevance 0
We also examined the expression of two mitogen-activated protein (MAP) kinases, activated p38 and extracellular signal-regulated kinases 1 and 2 (ERK1/2), which are known to contribute to chronic pain, within these human neuromas.
Gene_expression (expression) of MAP associated with lasting pain and neuroma
11) Confidence 0.18 Published 2008 Journal Ann. Neurol. Section Abstract Doc Link 19107992 Disease Relevance 0.62 Pain Relevance 1.20
During preliminary data analyses the ICP to CPP ratio (ICP/(MAP - ICP)) was found to be highly discriminate for surviving and non-surviving patients.
Gene_expression (/) of MAP associated with cva
12) Confidence 0.08 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 1.18 Pain Relevance 0.33
The ICP, MAP, BIS, and StcO2 values were recorded hourly for each of the first six post-injury days.
Gene_expression (values) of MAP associated with injury and cva
13) Confidence 0.07 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 1.23 Pain Relevance 0.29
Here, if MAP was present in the plasma it was binding to the phage through MptD.
Gene_expression (present) of MAP in plasma associated with paratuberculosis
14) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2636876 Disease Relevance 1.23 Pain Relevance 0
We harnessed the potential of fMptD and the MptD peptide alone for the detection of MAP in diabetic patients' blood.
Gene_expression (detection) of MAP in blood associated with diabetes mellitus and paratuberculosis
15) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2636876 Disease Relevance 0.92 Pain Relevance 0
Recently it was validated as a diagnostic target for the detection of MAP in a large number of bulk milk samples obtained from MAP infected herds [15].
Gene_expression (detection) of MAP associated with paratuberculosis
16) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2636876 Disease Relevance 1.39 Pain Relevance 0.03
ELISA with fMptD, MptD peptide and other MAP antigen (s) - HbHA, Gsd and MAP whole cell lysate
Gene_expression (antigen) of MAP associated with paratuberculosis
17) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2636876 Disease Relevance 0.58 Pain Relevance 0
Another important reason to argue in favour of the specificity of the test is that it is specific to a mycobacterial envelope protein MptD, which is uniquely present only in MAP [14], [15].
Gene_expression (present) of MAP associated with paratuberculosis
18) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2636876 Disease Relevance 1.29 Pain Relevance 0
57) were tested as compared to the same control individuals for the MptD peptide, fMptD and MAP antigen ELISAs.
Gene_expression (peptide) of MAP associated with paratuberculosis
19) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2636876 Disease Relevance 1.36 Pain Relevance 0.04

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