INT389

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Context Info
Confidence 0.67
First Reported 1979
Last Reported 2011
Negated 1
Speculated 0
Reported most in Abstract
Documents 21
Total Number 21
Disease Relevance 10.31
Pain Relevance 8.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ace) peptidase activity (Ace) extracellular space (Ace)
extracellular region (Ace) plasma membrane (Ace)
Anatomy Link Frequency
Plasma 1
brain 1
autonomic 1
pancreas 1
basal ganglia 1
Ace (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 48 100.00 Very High Very High Very High
Neuropeptide 11 100.00 Very High Very High Very High
Inflammation 51 99.78 Very High Very High Very High
B1 receptor 91 99.26 Very High Very High Very High
anesthesia 14 98.92 Very High Very High Very High
Potency 3 98.36 Very High Very High Very High
ketamine 14 98.28 Very High Very High Very High
bradykinin 61 97.72 Very High Very High Very High
halothane 12 97.44 Very High Very High Very High
Angina 1 96.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hyperkalemia 6 99.96 Very High Very High Very High
INFLAMMATION 55 99.78 Very High Very High Very High
Hypertension 130 99.58 Very High Very High Very High
Left Ventricular Hypertrophy 19 99.44 Very High Very High Very High
Hypertrophy 6 98.92 Very High Very High Very High
Nephritis 1 98.44 Very High Very High Very High
Diabetic Nephropathy 1 98.16 Very High Very High Very High
Stroke 2 97.84 Very High Very High Very High
Ureteral Obstruction 1 97.36 Very High Very High Very High
Adrenal Insufficiency 1 97.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Angiotensin-converting enzyme (ACE) produced primarily YGGF, MR, and lesser amounts of YGGFMR and YG.
Gene_expression (produced) of ACE
1) Confidence 0.67 Published 1985 Journal J. Biol. Chem. Section Abstract Doc Link 2982830 Disease Relevance 0 Pain Relevance 0.13
ACE inhibitors may produce hyperkalaemia, particularly in patients with autonomic neuropathy, adrenal insufficiency, renal impairment and when used in combination with nonsteroidal anti-inflammatory drugs (NSAIDs).
Gene_expression (produce) of ACE in autonomic associated with inflammation, hyperkalemia, cinod, adrenal insufficiency and diabetic nephropathy
2) Confidence 0.66 Published 1995 Journal Drug Saf Section Abstract Doc Link 7646822 Disease Relevance 0.62 Pain Relevance 0.26
Angiotensin receptor blocker–ACE inhibitor combination therapy
Gene_expression (therapy) of ACE
3) Confidence 0.64 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291334 Disease Relevance 1.02 Pain Relevance 0.10
Neutral endopeptidase 24.11 (NEP) and angiotensin-converting enzyme (ACE) degrade neuropeptides, including enkephalin and are expressed in the brain.
Gene_expression (expressed) of ACE in brain associated with neuropeptide and enkephalin
4) Confidence 0.63 Published 1998 Journal Biochim. Biophys. Acta Section Abstract Doc Link 9630637 Disease Relevance 0.07 Pain Relevance 0.78
In the absence of intra-pancreatic ACE levels in these patients, there may exist a possibility that in contrast to other tissues such as heart and renal tissue, DD genotype does not influence the ACE gene expression and consequently its levels in the pancreas.


Gene_expression (expression) of ACE in pancreas
5) Confidence 0.57 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1762011 Disease Relevance 1.59 Pain Relevance 0.55
An insertion/deletion (I/D) polymorphism of the ACE gene [10] accounting for half the variance in serum ACE levels has been described.
Gene_expression (levels) of serum ACE
6) Confidence 0.57 Published 2008 Journal The Open Neurology Journal Section Body Doc Link PMC2627518 Disease Relevance 1.03 Pain Relevance 0.30
Differences in the rates of conversion of angiotensin I to angiotensin II induced by various anesthetic agents could help explain these previous findings.
Gene_expression (conversion) of angiotensin I
7) Confidence 0.57 Published 1979 Journal Anesthesiology Section Abstract Doc Link 35043 Disease Relevance 0 Pain Relevance 0.66
Local inhibition of angiotensin-converting enzyme (ACE, kininase II) produces both attenuation of angiotensin (Ang) II generation and bradykinin (BK) degradation.
Gene_expression (produces) of ACE associated with bradykinin
8) Confidence 0.54 Published 1990 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 1697370 Disease Relevance 0.36 Pain Relevance 0.29
Captopril at doses which blocked conversion of angiotensin I to II inhibited the degradation of enkephalins across the lung.
Gene_expression (conversion) of angiotensin I in lung associated with enkephalin
9) Confidence 0.52 Published 1984 Journal Life Sci. Section Abstract Doc Link 6384711 Disease Relevance 0 Pain Relevance 0.61
Plasma renin activity (rate of angiotensin I generation) does not increase during anesthesia with ketamine, fluroxene, halothane or enflurane in the sodium-repleted rat.
Gene_expression (generation) of angiotensin I in Plasma associated with anesthesia, ketamine and halothane
10) Confidence 0.51 Published 1979 Journal Anesthesiology Section Abstract Doc Link 35043 Disease Relevance 0 Pain Relevance 0.55
The expression of ACE after the initial presence of known peptides in the basal ganglia implies that the enzyme is not essential for peptide synthesis, suggesting instead a degradative role.
Gene_expression (expression) of ACE in basal ganglia
11) Confidence 0.50 Published 1986 Journal Brain Res. Section Abstract Doc Link 3021286 Disease Relevance 0 Pain Relevance 0.49
Local inhibition of angiotensin-converting enzyme (ACE, kininase II) produces both attenuation of angiotensin (Ang) II generation and bradykinin (BK) degradation.
Gene_expression (produces) of kininase II associated with bradykinin
12) Confidence 0.48 Published 1990 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 1697370 Disease Relevance 0.36 Pain Relevance 0.29
These peptides interact to produce angiotensin I, a biologically inactive decapeptide that is subsequently cleaved by angiotensin I converting enzyme (ACE) to produce the effector octapeptide angiotensin II (Ang II).
Gene_expression (produce) of angiotensin I
13) Confidence 0.38 Published 2010 Journal Radiat Oncol Section Body Doc Link PMC2825515 Disease Relevance 0.71 Pain Relevance 0.23
Li et al.24 have suggested that the LVH in SHR was associated with ACE and ACE2 gene expression cardiac RAS, while aortic hypertrophy was associated with angiotensinogen and ACE2 gene expression of aortic RAS.
Gene_expression (expression) of ACE associated with hypertrophy, left ventricular hypertrophy and hypertension
14) Confidence 0.33 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC3020347 Disease Relevance 0.79 Pain Relevance 0
This new observation is in keeping with the demonstration of an important role for mast cell derived chymase in Ang II formation following either decreased expression [29] or pharmacological blockade of ACE [30] This finding also agrees with Prosser et al. [29] report that chymostatin completely inhibited Ang II formation from Ang-(1–12).
Gene_expression (expression) of ACE in mast cell
15) Confidence 0.29 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3018413 Disease Relevance 0.34 Pain Relevance 0
Morrissey and Klahr showed that ACE inhibition decreased NF-?
Neg (inhibition) Gene_expression (inhibition) of ACE
16) Confidence 0.27 Published 2002 Journal BMC Cardiovasc Disord Section Body Doc Link PMC65512 Disease Relevance 1.12 Pain Relevance 0.11
For instance, genetic disruption of B1R or B2R and both receptors decreased ACE and ANG II AT1R function and expression in mice abdominal aorta, indicating that kinin receptors regulate AT1 receptors and ACE [76], [77].
Gene_expression (expression) of ACE in abdominal aorta associated with b1 receptor
17) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935380 Disease Relevance 1.27 Pain Relevance 0.41
Angiotensin I was effectively hydrolyzed (Km = 0.06 mM, kcat = 6.48 s-1) and produced both des-Leu10-angiotensin I and angiotensin II.
Gene_expression (produced) of Angiotensin I
18) Confidence 0.19 Published 1989 Journal Biochim. Biophys. Acta Section Abstract Doc Link 2713418 Disease Relevance 0 Pain Relevance 0
Angiotensin I was effectively hydrolyzed (Km = 0.06 mM, kcat = 6.48 s-1) and produced both des-Leu10-angiotensin I and angiotensin II.
Gene_expression (produced) of angiotensin I
19) Confidence 0.17 Published 1989 Journal Biochim. Biophys. Acta Section Abstract Doc Link 2713418 Disease Relevance 0 Pain Relevance 0
B in the expressional regulation of this receptor [54]; 7) The important inflammatory modulator ACE reduces NF?
Gene_expression (reduces) of ACE associated with inflammation
20) Confidence 0.07 Published 2007 Journal J Biomed Discov Collab Section Body Doc Link PMC1871567 Disease Relevance 1.01 Pain Relevance 0.55

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