INT38906

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Context Info
Confidence 0.62
First Reported 1985
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 3.11
Pain Relevance 2.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Hrh2) signal transducer activity (Hrh2)
Hrh2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 11 100.00 Very High Very High Very High
cINOD 107 99.08 Very High Very High Very High
nud 3 97.44 Very High Very High Very High
COX-2 inhibitor 3 85.80 High High
peptic ulcer disease 3 75.84 Quite High
Inflammation 2 50.00 Quite Low
Pain 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Ulcers 74 99.12 Very High Very High Very High
Disease 6 98.88 Very High Very High Very High
Gastritis 9 97.92 Very High Very High Very High
Acid Reflux 3 97.72 Very High Very High Very High
Dyspepsia 1 97.44 Very High Very High Very High
Infection 2 97.28 Very High Very High Very High
Duodenal Ulcer 11 96.80 Very High Very High Very High
INFLAMMATION 6 95.32 Very High Very High Very High
Gastrointestinal Disease 1 73.76 Quite High
Toxicity 2 71.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The clinical diagnosis of gastritis was found to be the major indication for antacids and anticholinergic drugs and accounted for a substantial proportion of H2-receptor antagonist prescriptions.
Transcription (prescriptions) of H2-receptor associated with antagonist and gastritis
1) Confidence 0.62 Published 1985 Journal Scand. J. Gastroenterol. Suppl. Section Abstract Doc Link 3860921 Disease Relevance 1.06 Pain Relevance 0.17
In Japan, histamine-2 receptor antagonists are frequently prescribed, but the literature regarding their efficacy is limited.
Transcription (prescribed) of histamine-2 associated with antagonist
2) Confidence 0.62 Published 2006 Journal J. Gastroenterol. Section Abstract Doc Link 17287897 Disease Relevance 0.29 Pain Relevance 0.41
Despite lower serum nizatidine concentrations, gastric pH was higher in the evening than in the daytime; it is speculated that this was due to a time-dependent enhanced distribution of the H2-receptor blocker into the site of action.
Transcription (distribution) of H2-receptor
3) Confidence 0.62 Published 1995 Journal J Clin Pharmacol Section Abstract Doc Link 8626880 Disease Relevance 0.37 Pain Relevance 0.07
Dyspepsia scores fell significantly following the UBT, reflected by a reduced number of visits to the general practitioner and a fall in H2-receptor antagonist prescriptions.
Transcription (prescriptions) of H2-receptor associated with antagonist and nud
4) Confidence 0.61 Published 1999 Journal Eur J Gastroenterol Hepatol Section Abstract Doc Link 10503825 Disease Relevance 0.48 Pain Relevance 0.24
Ranitidine is a histamine H 2-receptor antagonist which, on the basis of its well established tolerability and efficacy profile, has been widely prescribed for the treatment of ulcer disease and mild to moderate reflux oesophagitis.
Transcription (prescribed) of histamine H 2-receptor associated with acid reflux, antagonist, ulcers and disease
5) Confidence 0.60 Published 1994 Journal Pharmacoeconomics Section Abstract Doc Link 10147354 Disease Relevance 0.62 Pain Relevance 0.09
Furthermore, prescribing H2 receptor antagonists was found to be possibly cost effective in all patients requiring NSAIDs [17,18].
Transcription (prescribing) of H2 receptor associated with antagonist and cinod
6) Confidence 0.04 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656249 Disease Relevance 0.30 Pain Relevance 1.05

General Comments

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