INT38916

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Context Info
Confidence 0.33
First Reported 1985
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 1.92
Pain Relevance 1.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Tert) DNA binding (Tert) cytoplasm (Tert)
chromosome (Tert) nucleolus (Tert) nucleus (Tert)
Anatomy Link Frequency
skin 1
Tert (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Cholecystokinin 8 99.76 Very High Very High Very High
Pain 6 94.92 High High
Rsd 8 93.56 High High
cerebral cortex 17 88.40 High High
Enkephalin 1 88.00 High High
Inflammation 2 78.48 Quite High
addiction 8 44.28 Quite Low
alcohol 24 43.84 Quite Low
Central nervous system 8 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 5 94.92 High High
Reflex Sympathetic Dystrophy 8 93.56 High High
Chromosomal Instability 8 82.32 Quite High
INFLAMMATION 2 78.48 Quite High
Death 20 78.40 Quite High
Apoptosis 76 78.08 Quite High
Cancer 9 75.44 Quite High
Neuropathic Pain 2 73.12 Quite High
Alcohol Addiction 4 44.28 Quite Low
Ataxia 4 40.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Reverse transcription PCR (Figure 8A, B) shows that TERT mRNA levels were modestly but statistically significantly increased (p < 0.05) at the low ethanol dosage (120 mg/ml).
Positive_regulation (increased) of TERT mRNA
1) Confidence 0.33 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1249578 Disease Relevance 0 Pain Relevance 0
The lower dose of ethanol (120 mg/dl) resulted in increased TERT mRNA levels, perhaps as a compensatory protective response.
Positive_regulation (resulted) of TERT mRNA
2) Confidence 0.33 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1249578 Disease Relevance 0.44 Pain Relevance 0
The lower dose of ethanol (120 mg/dl) resulted in increased TERT mRNA levels, perhaps as a compensatory protective response.
Positive_regulation (increased) of TERT mRNA
3) Confidence 0.22 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1249578 Disease Relevance 0.44 Pain Relevance 0
The increase in TERT transcription following low doses of ethanol (120 mg/dl) was not followed by a measurable increase in telomerase activity, an unexpected observation in light of the marked induction of DNA synthesis and cell-cycle progression illustrated in Figure 2A, B.
Positive_regulation (increase) of TERT
4) Confidence 0.20 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1249578 Disease Relevance 0 Pain Relevance 0
Infusion with tert-BuOOH induced in the left paw an increased skin temperature, increased volume, redness of the plantar skin, impaired function and increased pain sensation, while these acute RSD signs and symptoms were absent in the saline infused animals.
Positive_regulation (induced) of tert-BuOOH in skin associated with rsd and pain
5) Confidence 0.10 Published 1998 Journal Acta Orthop Belg Section Abstract Doc Link 9689763 Disease Relevance 1.04 Pain Relevance 0.82
Among the latter, the shortest substrate was tert-butoxycarbonylaspartyltyrosine (Boc-Asp-Tyr), but the reaction was optimized by increasing the length of the peptide sequence on the C-terminal side up to tert-butoxycarbonylcholecystokinin octapeptide (Boc-CCK-8) as well as by the presence of acidic amino acid residues at the N-terminal side.
Positive_regulation (increasing) of tert-butoxycarbonylcholecystokinin octapeptide associated with cholecystokinin
6) Confidence 0.04 Published 1985 Journal Biochemistry Section Abstract Doc Link 3866608 Disease Relevance 0 Pain Relevance 0.46

General Comments

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