INT3892
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Stirpe and co-workers reported that the level of total XOR was significantly higher in liver with virus-related cirrhosis but not in virus-negative cirrhosis, as compared to the controls.35,40,41 The level of XOR was increased in cirrhotic liver, in association with viral infection. | |||||||||||||||
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We hypothesize that the elevated serum XO activity in patients with CCHF is related to the free radicals generated by the xanthine/XO system. | |||||||||||||||
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The aim of the present study was to investigate the serum levels of ADA-2 (the main source of ADA activity in the serum, which plays crucial roles in immune function) and xanthine oxidase (which increases tissue damage via the formation of free oxygen radicals) in CCHF patients and to compare the results with those obtained for healthy controls. | |||||||||||||||
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Adenosine deaminase and xanthine oxidase levels were increased in patients with Crimean–Congo hemorrhagic fever. | |||||||||||||||
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Elevated serum xanthine oxidase activity in patients with Crimean–Congo hemorrhagic fever may be associated with reactive oxygen species generated by the xanthine/xanthine oxidase system during inflammatory responses. | |||||||||||||||
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The hepatotoxicity was demonstrated by the elevation in the serum activity of xanthine oxidase, a highly sensitive marker for acute liver damage. | |||||||||||||||
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Elevation of serum xanthine oxidase activity following halothane anesthesia in man. | |||||||||||||||
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Despite this, the activity of endothelial bound XO is increased by more than 200% in patients with CHF.36 Furthermore, studies using electron spin resonance have demonstrated that endothelial oxygen tension is thought to regulate XO activity at a post-translational level as demonstrated by a doubling in XOR activity post exposure to hypoxia without any increase in mRNA expression for 24 hours in bovine aortic endothelial cells.37 Cells produce a marked elevation in XO levels when exposed to ischemia38 and XDH conversion to XO is also accelerated in hypoxia.39 When infused acutely, XO produces a marked decrease in cardiac contractility, cardiac index and left ventricular systolic pressure.40 In atherosclerotic plaques, urate levels are found to be elevated six-fold, reflecting accelerated purine oxidation within these plaques. | |||||||||||||||
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Despite this, the activity of endothelial bound XO is increased by more than 200% in patients with CHF.36 Furthermore, studies using electron spin resonance have demonstrated that endothelial oxygen tension is thought to regulate XO activity at a post-translational level as demonstrated by a doubling in XOR activity post exposure to hypoxia without any increase in mRNA expression for 24 hours in bovine aortic endothelial cells.37 Cells produce a marked elevation in XO levels when exposed to ischemia38 and XDH conversion to XO is also accelerated in hypoxia.39 When infused acutely, XO produces a marked decrease in cardiac contractility, cardiac index and left ventricular systolic pressure.40 In atherosclerotic plaques, urate levels are found to be elevated six-fold, reflecting accelerated purine oxidation within these plaques. | |||||||||||||||
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, lipo-polysaccharides as well as steroid treatment have been shown to upregulate transcription.16 XO is significantly elevated in a variety of conditions including limb ischemia,30 major surgery31 coronary artery disease (CAD)32 and heart failure.33 Circulating XO binds to glycosaminoglycans on the surface of endothelial cells where it is thought it acquires modified kinetics (higher Km and Ki, oxidant producing capacity, and increased stability).34 There are suggestions that this form of induced, circulating and depositing XO appears to be more important in the pathogenesis of endothelial injury compared with XO constitutively produced from endothelial cells.35 | |||||||||||||||
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The inefficiency increases with the size of the grid; for example an XOR-grid of a million elements is needed to generate 1000 bits of integrated information. ? | |||||||||||||||
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A single nucleotide polymorphism analysis of the cat XDH gene strongly indicated that the XDH gene of the patient cat was composed of two kinds of alleles and ruled out the hypothesis that the cat inherited the same recessive XDH allele suggesting no activity from a single ancestor. | |||||||||||||||
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