INT38931

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Context Info
Confidence 0.78
First Reported 1983
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.87
Pain Relevance 1.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (APRT) small molecule metabolic process (APRT) transferase activity, transferring glycosyl groups (APRT)
nucleolus (APRT) nucleus (APRT) cytoplasm (APRT)
Anatomy Link Frequency
muscle 1
APRT (Homo sapiens)
Pain Link Frequency Relevance Heat
epidural 4 99.08 Very High Very High Very High
analgesia 4 98.72 Very High Very High Very High
Enkephalin 9 98.16 Very High Very High Very High
narcan 3 96.80 Very High Very High Very High
Opioid 5 88.08 High High
Dynorphin 2 79.68 Quite High
Pain 1 75.68 Quite High
opiate 2 59.84 Quite High
addiction 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 4 97.28 Very High Very High Very High
Fever 4 94.20 High High
Pain 1 75.68 Quite High
Fatigue 8 74.40 Quite High
Acidosis 2 58.24 Quite High
Acid Base Imbalance 7 49.64 Quite Low
Obesity 1 5.00 Very Low Very Low Very Low
Rigor 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The rise in islet c-AMP and insulin secretion induced by DAMME and alpha-endorphin but not leu enkephalin was antagonised by naloxone.
Localization (secretion) of AMP associated with narcan and enkephalin
1) Confidence 0.78 Published 1983 Journal Horm. Metab. Res. Section Abstract Doc Link 6133828 Disease Relevance 0 Pain Relevance 1.11
The findings are also consistent with regulation of interleukin-1 release which is independent of adrenal stimulation, cyclic AMP or beta-endorphin, as epidural analgesia prevents postoperative increase of these hormones.
Localization (release) of AMP associated with epidural and analgesia
2) Confidence 0.68 Published 1985 Journal Acta Chir Scand Section Abstract Doc Link 3872548 Disease Relevance 0.66 Pain Relevance 0.52
In other words, keeping AMP and ADP low within muscle, despite small reductions in ATP, can sustain sufficient free energy release during ATP hydrolysis to provide adequate energy to fuel muscle contraction.
Localization (release) of AMP in muscle
3) Confidence 0.10 Published 2010 Journal Journal of Nutrition and Metabolism Section Body Doc Link PMC3005844 Disease Relevance 0.21 Pain Relevance 0.08

General Comments

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