INT38948

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Context Info
Confidence 0.36
First Reported 1985
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 3.47
Pain Relevance 1.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNFRSF10A) transcription factor binding (TNFRSF10A)
TNFRSF10A (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 5 99.08 Very High Very High Very High
Inflammation 1 98.76 Very High Very High Very High
spinal inflammation 7 98.48 Very High Very High Very High
cytokine 1 98.14 Very High Very High Very High
cINOD 4 96.40 Very High Very High Very High
complementary and alternative medicine 3 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 15 100.00 Very High Very High Very High
Rheumatoid Arthritis 5 99.08 Very High Very High Very High
INFLAMMATION 2 98.76 Very High Very High Very High
Low Back Pain 7 98.48 Very High Very High Very High
Stomach Cancer 3 98.20 Very High Very High Very High
Apoptosis 51 97.40 Very High Very High Very High
Sacroiliitis 3 95.56 Very High Very High Very High
Cancer 14 93.20 High High
Malignant Neoplastic Disease 1 67.84 Quite High
Breast Cancer 48 58.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
They carried the B27-DR4 haplotype, suggesting a possible dual genetic association of the same haplotype in both RA and AS.
DR4 Binding (association) of associated with spinal inflammation and rheumatoid arthritis
1) Confidence 0.36 Published 1985 Journal J. Rheumatol. Section Abstract Doc Link 3876435 Disease Relevance 1.36 Pain Relevance 0.86
Non-steroidal anti-inflammatory drug activated gene (NAG-1) expression is closely related to death receptor-4 and -5 induction, which may explain sulindac sulfide induced gastric cancer cell apoptosis.
death receptor-4 Binding (induction) of associated with inflammation, apoptosis, stomach cancer, death and cytokine
2) Confidence 0.03 Published 2004 Journal Carcinogenesis Section Title Doc Link 15180942 Disease Relevance 1.11 Pain Relevance 0.46
In the extrinsic death receptor/ligands pathway, caspase activation occurs as a direct consequence of death receptor ligation, with upstream caspase-8 cleaving and activating downstream proteases such as caspase-9 and caspase-3.
death receptor Binding (ligation) of associated with death
3) Confidence 0.01 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2730474 Disease Relevance 1.00 Pain Relevance 0

General Comments

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