INT38964

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Context Info
Confidence 0.37
First Reported 1985
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.52
Pain Relevance 1.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
brain 1
Lsd (Mus musculus)
Pain Link Frequency Relevance Heat
cannabis 6 100.00 Very High Very High Very High
cocaine 4 98.72 Very High Very High Very High
Serotonin 3 95.92 Very High Very High Very High
Locus ceruleus 5 90.56 High High
Ventral tegmentum 3 86.44 High High
Raphe 1 83.68 Quite High
Eae 1 83.32 Quite High
depression 9 78.84 Quite High
Onset of action 2 77.00 Quite High
Dopamine 3 76.52 Quite High
Disease Link Frequency Relevance Heat
Depression 9 78.84 Quite High
Cognitive Disorder 2 76.60 Quite High
Pain 5 57.36 Quite High
Chronic Disease 1 56.76 Quite High
Stress 2 54.52 Quite High
Communicable Diseases 1 51.12 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 10 37.92 Quite Low
Injury 13 15.64 Low Low
Suicidal Behaviour 8 14.76 Low Low
Alcohol Addiction 2 14.04 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
With the exception of the effect on rearings and holepokes, the effects of LSD were diminished in rats depleted of brain NE.
Negative_regulation (diminished) of LSD in brain
1) Confidence 0.37 Published 1985 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 3877938 Disease Relevance 0 Pain Relevance 0.33
The suppressant effect of LSD was significantly diminished after the two-day regimen, indicating a desensitization of 5-HT1A autoreceptors.
Negative_regulation (effect) of LSD
2) Confidence 0.11 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18708076 Disease Relevance 0.07 Pain Relevance 0.63
When these proportions are compared with data on lifetime use of illicit drugs from the same survey, the rates of use in each of the three categories decrease slightly: 18.7% for cannabis, 3.6% for LSD, speed or heroin, and 2.7% for cocaine.
Negative_regulation (decrease) of LSD associated with cannabis and cocaine
3) Confidence 0.10 Published 2004 Journal BMC Womens Health Section Body Doc Link PMC2096682 Disease Relevance 0.45 Pain Relevance 0.36

General Comments

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