INT38967

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Context Info
Confidence 0.40
First Reported 1982
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 12
Total Number 12
Disease Relevance 2.55
Pain Relevance 2.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Ctrc)
Anatomy Link Frequency
plasma 1
gland 1
Ctrc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain score 3 99.46 Very High Very High Very High
qutenza 10 99.28 Very High Very High Very High
substance P 11 98.88 Very High Very High Very High
Chronic pancreatitis 17 98.84 Very High Very High Very High
tetrodotoxin 1 91.36 High High
abdominal pain 7 88.44 High High
antagonist 2 79.28 Quite High
Bile 6 52.08 Quite High
metalloproteinase 1 34.60 Quite Low
Inflammation 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Pain 4 99.34 Very High Very High Very High
Pancreatitis 26 98.84 Very High Very High Very High
Disease Susceptibility 2 89.80 High High
Hypertrophy 2 89.28 High High
Abdominal Pain 7 88.44 High High
Disease 3 79.04 Quite High
Calcification 2 75.00 Quite High
Appendicitis 6 50.00 Quite Low
Diabetes Mellitus 4 5.00 Very Low Very Low Very Low
Toxicity 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: Ninety-four children successfully underwent CTRC.
Positive_regulation (underwent) of CTRC
1) Confidence 0.40 Published 2005 Journal Pediatr Radiol Section Body Doc Link 15633057 Disease Relevance 0 Pain Relevance 0
All 94 patients underwent CTRC.
Positive_regulation (underwent) of CTRC
2) Confidence 0.40 Published 2005 Journal Pediatr Radiol Section Body Doc Link 15633057 Disease Relevance 0 Pain Relevance 0
Association of rare chymotrypsinogen C (CTRC) gene variations in patients with idiopathic chronic pancreatitis.
Positive_regulation (variations) of CTRC associated with chronic pancreatitis
3) Confidence 0.35 Published 2008 Journal Hum. Genet. Section Title Doc Link 18172691 Disease Relevance 0.48 Pain Relevance 0.31
This genetic finding, when considered in the perceived role of CTRC in eliminating prematurely activated trypsin, indicated that CTRC is a new pancreatitis susceptibility gene.
Positive_regulation (role) of CTRC associated with pancreatitis
4) Confidence 0.31 Published 2008 Journal Hum. Genet. Section Abstract Doc Link 18172691 Disease Relevance 0.57 Pain Relevance 0.41
A total of 2.3% (3/126) of our CP patients carried variations of the CTRC gene.
Positive_regulation (variations) of CTRC gene
5) Confidence 0.19 Published 2009 Journal Pancreatology Section Body Doc Link 19407484 Disease Relevance 0.07 Pain Relevance 0
Feeding a high-casein (60%) diet but not a high-amino acid diet to PBD rats increased pancreatic trypsin and chymotrypsin activities compared with those after feeding a 25% casein diet.
Positive_regulation (increased) of chymotrypsin
6) Confidence 0.15 Published 2000 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 10859224 Disease Relevance 0.09 Pain Relevance 0.23
Feeding a high-casein (60%) diet but not a high-amino acid diet to PBD rats increased pancreatic trypsin and chymotrypsin activities compared with those after feeding a 25% casein diet.
Positive_regulation (pancreatic) of chymotrypsin
7) Confidence 0.11 Published 2000 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 10859224 Disease Relevance 0.09 Pain Relevance 0.23
Trypsin was significantly stimulated by curcumin, capsaicin, piperine, ginger and cumin, while chymotrypsin was stimulated by all the spices tested except mustard.
Positive_regulation (stimulated) of chymotrypsin associated with qutenza
8) Confidence 0.05 Published 2000 Journal Nahrung Section Abstract Doc Link 10702999 Disease Relevance 0 Pain Relevance 0.36
A sufficient amount of a pH-lowering buffer that lowers local intestinal pH to values below 4.5 can deactivate trypsin, chymotrypsin and elastase1.


Positive_regulation (deactivate) of chymotrypsin
9) Confidence 0.03 Published 2008 Journal Indian Journal of Pharmaceutical Sciences Section Body Doc Link PMC2792531 Disease Relevance 0 Pain Relevance 0.03
The addition of exogenous peptidases such as pronase, chymotrypsin and an extract of black widow spider venom gland dramatically increased the rate of degradation of SP, shortened the fading response and blocked the development of tachyphylaxis.
Positive_regulation (increased) of chymotrypsin in gland associated with substance p
10) Confidence 0.02 Published 1982 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6180910 Disease Relevance 0 Pain Relevance 0.52
We examined the maximal serum PABA concentration within 3 hrs (MS-PABA) and the 6 hr urinary PABA recovery (6 hr U-PABA) after BT-PABA administration, PABA excretion index, and chymotrypsin secretory response to caerulein-secretin stimulation in ten control subjects and fifteen patients with chronic pancreatitis diagnosed on the basis of pancreatograms.
Positive_regulation (response) of chymotrypsin associated with chronic pancreatitis
11) Confidence 0.01 Published 1985 Journal Gastroenterol. Jpn. Section Abstract Doc Link 3878311 Disease Relevance 0.23 Pain Relevance 0.23
Patients were evaluated prospectively (median follow-up 13 months) for pain score, fasting and oral glucose stimulated plasma C-peptide, serum trypsin, and fecal chymotrypsin.
Positive_regulation (stimulated) of chymotrypsin in plasma associated with pain score
12) Confidence 0.00 Published 2002 Journal World J Surg Section Abstract Doc Link 11865345 Disease Relevance 1.03 Pain Relevance 0.44

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