INT38987

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Context Info
Confidence 0.99
First Reported 1985
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 21
Total Number 21
Disease Relevance 11.92
Pain Relevance 2.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (INS) small molecule metabolic process (INS) extracellular region (INS)
carbohydrate metabolic process (INS) cell-cell signaling (INS)
Anatomy Link Frequency
fibroblasts 4
internal 2
pancreatic beta cell 1
muscle 1
plaque 1
INS (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 16 99.92 Very High Very High Very High
opiate 2 99.30 Very High Very High Very High
chemokine 4 99.06 Very High Very High Very High
cytokine 17 98.76 Very High Very High Very High
Inflammatory mediators 18 98.08 Very High Very High Very High
metalloproteinase 5 91.68 High High
Opioid 4 88.68 High High
Endogenous opioid 1 85.72 High High
addiction 4 79.24 Quite High
Inflammatory marker 1 76.00 Quite High
Disease Link Frequency Relevance Heat
Insulin Resistance 49 100.00 Very High Very High Very High
Hyperinsulinism 4 100.00 Very High Very High Very High
Pancreatitis 20 99.92 Very High Very High Very High
Apnoea 61 99.84 Very High Very High Very High
Diabetes Mellitus 307 99.40 Very High Very High Very High
Obesity 173 99.40 Very High Very High Very High
INFLAMMATION 111 98.08 Very High Very High Very High
Hyperglycemia 20 97.68 Very High Very High Very High
Pulmonary Disease 95 97.36 Very High Very High Very High
Amyloid Plaque 5 96.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
internal insulin becomes gradually degraded, and metabolisms that exchange
Protein_catabolism (degraded) of insulin in internal
1) Confidence 0.99 Published 2008 Journal International Journal of Telemedicine and Applications Section Body Doc Link PMC2271045 Disease Relevance 1.36 Pain Relevance 0
of internal insulin are largely degraded, it cannot appropriately facilitate
Protein_catabolism (degraded) of insulin in internal
2) Confidence 0.99 Published 2008 Journal International Journal of Telemedicine and Applications Section Body Doc Link PMC2271045 Disease Relevance 1.24 Pain Relevance 0
To evaluate the role of three enzymes of insulin degradation (neutral protease, microsomal glutathione insulin transhydrogenase, and lysosomal acid protease), we subfractionated homogenized fibroblasts into membrane (and nuclei) cytosol, mitochondria, microsomes, and lysosomes.
Protein_catabolism (degradation) of insulin in fibroblasts
3) Confidence 0.97 Published 1985 Journal Endocrinology Section Abstract Doc Link 3882399 Disease Relevance 0 Pain Relevance 0.06
This fraction, similar to the intact fibroblast degrades insulin to two intermediates with similar molecular weight to that of intact insulin but with more hydrophilicity and less binding affinity to antiinsulin antibody and liver membrane than intact insulin.
Protein_catabolism (degrades) of insulin in fibroblast
4) Confidence 0.97 Published 1985 Journal Endocrinology Section Abstract Doc Link 3882399 Disease Relevance 0 Pain Relevance 0.06
Sweets release opiates which stimulates the appetite for sucrose--insulin can depress it].
Protein_catabolism (sucrose--) of insulin associated with opiate
5) Confidence 0.89 Published 2005 Journal Lakartidningen Section Title Doc Link 15962882 Disease Relevance 0.24 Pain Relevance 0.61
The degradation rate constants of human insulin was approximately half of that for porcine insulin.
Protein_catabolism (degradation) of porcine insulin
6) Confidence 0.88 Published 1985 Journal J. Pharmacobio-dyn. Section Abstract Doc Link 3891962 Disease Relevance 0 Pain Relevance 0
The degradation rate constants of human insulin was approximately half of that for porcine insulin.
Protein_catabolism (degradation) of insulin
7) Confidence 0.87 Published 1985 Journal J. Pharmacobio-dyn. Section Abstract Doc Link 3891962 Disease Relevance 0 Pain Relevance 0
Characterization of insulin-degrading activity of intact and subcellular components of human fibroblasts.
Protein_catabolism (degrading) of insulin in fibroblasts
8) Confidence 0.86 Published 1985 Journal Endocrinology Section Title Doc Link 3882399 Disease Relevance 0 Pain Relevance 0.12
Selective arterial calcium stimulation showed a high insulin gradient in the splenic and superior mesenteric arteries, suggesting diffuse pancreatic beta cell hyperplasia.
Protein_catabolism (gradient) of insulin in pancreatic beta cell associated with hyperinsulinism and hyperplasia
9) Confidence 0.85 Published 2010 Journal BMC Gastroenterol Section Abstract Doc Link PMC2914776 Disease Relevance 0.89 Pain Relevance 0
Degradation and absorption of insulins in the rat.
Protein_catabolism (Degradation) of insulin
10) Confidence 0.77 Published 1985 Journal J. Pharmacobio-dyn. Section Title Doc Link 3891962 Disease Relevance 0 Pain Relevance 0
To evaluate the role of three enzymes of insulin degradation (neutral protease, microsomal glutathione insulin transhydrogenase, and lysosomal acid protease), we subfractionated homogenized fibroblasts into membrane (and nuclei) cytosol, mitochondria, microsomes, and lysosomes.
Protein_catabolism (degradation) of insulin in fibroblasts
11) Confidence 0.75 Published 1985 Journal Endocrinology Section Abstract Doc Link 3882399 Disease Relevance 0 Pain Relevance 0.06
Consequently, diabetes may be worsened by enzymatic degradation of insulin by gelatinase B and by the consequent enhancement of the autoimmune process.
Protein_catabolism (degradation) of insulin associated with diabetes mellitus
12) Confidence 0.70 Published 2003 Journal FASEB J. Section Abstract Doc Link 12626433 Disease Relevance 0.49 Pain Relevance 0.45
These model structures include the possibility for multiple binding of insulin to the IR (?
Protein_catabolism (multiple) of insulin
13) Confidence 0.58 Published 2008 Journal PLoS Computational Biology Section Body Doc Link PMC2424138 Disease Relevance 0 Pain Relevance 0
signaling, is extensively implicated in all aspects of skeletal muscle function [61], while at an individual gene level, the directional changes in ERK1/2 and MEK1/2 are consistent with the emerging mechanism through which saturated fatty acids induce muscle insulin resistance [62] and with decreased IRS-1 (insulin receptor substrate-1) phosphorylation [63] promoting the degradation of IRS-1 [64] and thus impaired insulin action.
Protein_catabolism (degradation) of insulin in muscle associated with insulin resistance
14) Confidence 0.48 Published 2010 Journal Genome Med Section Body Doc Link PMC2847700 Disease Relevance 0.77 Pain Relevance 0
Gelatinase B is diabetogenic in acute and chronic pancreatitis by cleaving insulin.
Protein_catabolism (cleaving) of insulin associated with chronic pancreatitis
15) Confidence 0.46 Published 2003 Journal FASEB J. Section Title Doc Link 12626433 Disease Relevance 0.50 Pain Relevance 0.44
Gelatinase B is diabetogenic in acute and chronic pancreatitis by cleaving insulin.
Protein_catabolism (cleaving) of insulin associated with chronic pancreatitis
16) Confidence 0.46 Published 2003 Journal FASEB J. Section Abstract Doc Link 12626433 Disease Relevance 0.55 Pain Relevance 0.44
Because gelatinase B processes cytokines and chemokines, we investigated whether and how gelatinase B cleaves insulin.
Protein_catabolism (cleaves) of insulin associated with chemokine and cytokine
17) Confidence 0.40 Published 2003 Journal FASEB J. Section Abstract Doc Link 12626433 Disease Relevance 0.50 Pain Relevance 0.45
The study by Bolton et al. [59] suggests that insulin resistance is aggravated by both, high BMI and increases in circulatory inflammatory mediators such as IL-6 in these patients.
Protein_catabolism (aggravated) of insulin associated with inflammatory mediators, obesity and insulin resistance
18) Confidence 0.30 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2857618 Disease Relevance 2.34 Pain Relevance 0.16
Given that OSA itself aggravates insulin resistance3,5,9,20,21 and tends to increase cardiovascular morbidity,2,12 early specialist referral for diagnosis and management of this condition might be anticipated to be beneficial.
Protein_catabolism (aggravates) of insulin associated with apnoea
19) Confidence 0.27 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2868349 Disease Relevance 1.38 Pain Relevance 0
These include APOE4, complement receptor 1, clusterin, insulin degrading enzyme, the APP homologue, APLP2, the APP binding protein APBBI1P, the collagen amyloid plaque component CLAC, synuclein, and the foetal Alzheimer antigen, ALZ50.
Protein_catabolism (degrading) of insulin in plaque associated with amyloid plaque
20) Confidence 0.06 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC3018626 Disease Relevance 1.60 Pain Relevance 0

General Comments

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