INT390

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Context Info
Confidence 0.70
First Reported 1975
Last Reported 2011
Negated 5
Speculated 6
Reported most in Abstract
Documents 170
Total Number 177
Disease Relevance 61.47
Pain Relevance 36.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Agt) aging (Agt) extracellular region (Agt)
extracellular matrix organization (Agt)
Anatomy Link Frequency
plasma 19
blood 8
nucleus 6
myocytes 5
kidney 4
Agt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 129 100.00 Very High Very High Very High
Clonidine 41 100.00 Very High Very High Very High
noradrenaline 37 100.00 Very High Very High Very High
Kinase C 20 100.00 Very High Very High Very High
Opioid 20 100.00 Very High Very High Very High
Potency 10 100.00 Very High Very High Very High
Antinociceptive 6 99.98 Very High Very High Very High
substance P 25 99.96 Very High Very High Very High
Intracerebroventricular 17 99.96 Very High Very High Very High
cINOD 12 99.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypertension 1039 100.00 Very High Very High Very High
Pressure And Volume Under Development 116 100.00 Very High Very High Very High
Heart Rate Under Development 105 100.00 Very High Very High Very High
Hyperphagia 4 100.00 Very High Very High Very High
Heart Arrhythmia 861 99.96 Very High Very High Very High
Insulin Resistance 30 99.96 Very High Very High Very High
Hyperaldosteronism 1 99.92 Very High Very High Very High
Increased Venous Pressure Under Development 84 99.76 Very High Very High Very High
Chronic Renal Failure 537 99.74 Very High Very High Very High
INFLAMMATION 339 99.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
(I.O.D.) of the hybridized dots revealed a 1-fold and 8-fold increase in Ang mNRA in rats receiving morphine injection for 1 and 4 days, respectively, and a 5-fold and 13-fold increase in rats receiving 3 and 6h EA stimulation, respectively.
Positive_regulation (increase) of Ang mNRA associated with electroacupuncture and morphine
1) Confidence 0.70 Published 1989 Journal Sheng Li Xue Bao Section Abstract Doc Link 2781313 Disease Relevance 0 Pain Relevance 0.77
Autoradiographic examination revealed a marked increase in Ang mRNA in rats receiving multiple injections of morphine or continuous electroacupuncture (EA) stimulation for several hours.
Positive_regulation (increase) of Ang mRNA associated with electroacupuncture and morphine
2) Confidence 0.70 Published 1989 Journal Sheng Li Xue Bao Section Abstract Doc Link 2781313 Disease Relevance 0 Pain Relevance 0.74
Using microbore high-performance liquid chromatography, we determined the concentrations of adenosine in plasma samples collected from (a) the left ventricle and jugular vein of anesthetized rats during acute intravenous infusions of angiotensin II (1, 10, and 100 ng/min) and (b) the carotid artery of conscious, unrestrained rats exposed to chronic elevations of either exogenous angiotensin II (intraperitoneal infusion of angiotensin II, 125 ng/min) or endogenous angiotensin II (induction of renovascular hypertension by clipping the left renal artery or by ligating the suprarenal aorta).
Positive_regulation (elevations) of angiotensin II in carotid artery associated with adenocard and hypertension
3) Confidence 0.69 Published 1991 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 1714001 Disease Relevance 0.15 Pain Relevance 0.32
Using microbore high-performance liquid chromatography, we determined the concentrations of adenosine in plasma samples collected from (a) the left ventricle and jugular vein of anesthetized rats during acute intravenous infusions of angiotensin II (1, 10, and 100 ng/min) and (b) the carotid artery of conscious, unrestrained rats exposed to chronic elevations of either exogenous angiotensin II (intraperitoneal infusion of angiotensin II, 125 ng/min) or endogenous angiotensin II (induction of renovascular hypertension by clipping the left renal artery or by ligating the suprarenal aorta).
Positive_regulation (induction) of angiotensin II in carotid artery associated with adenocard and hypertension
4) Confidence 0.69 Published 1991 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 1714001 Disease Relevance 0.15 Pain Relevance 0.29
During enalaprilat infusion, interstitial fluid concentration of Ang I was significantly increased from 0.78+/-0.06 to 0.97+/-0.08 nmol/L; however, Ang II concentrations were not altered significantly (3.67+/-0.28 versus 3.67+/-0.25 nmol/L).
Positive_regulation (increased) of Ang I
5) Confidence 0.69 Published 2002 Journal Hypertension Section Abstract Doc Link 11799091 Disease Relevance 0.08 Pain Relevance 0
The present results show it to be a competitive antagonist also in vivo since pA2 values are similar, always reaches a 100% response on increasing the Angiotensin II dose, and when relating log (DR-1) and log dose of agonist, the slope is very near to one (0.925).
Positive_regulation (increasing) of Angiotensin II associated with antagonist and agonist
6) Confidence 0.69 Published 1987 Journal Rev. Esp. Fisiol. Section Abstract Doc Link 3616115 Disease Relevance 0 Pain Relevance 0.14
Experimental study in 156 white rats with renovascular hypertension, posthemorrhagic hypotension and with normal blood pressure revealed that high--ressure oxygen (303.9 kPa--50 min) could activate angiotensin--converting enzyme, the latter taking part in inactivation of endogenous opioid peptides.
Positive_regulation (activate) of angiotensin in blood associated with pressure volume 2 under development, hypertension and endogenous opioid
7) Confidence 0.69 Published 1985 Journal Fiziol Zh SSSR Im I M Sechenova Section Abstract Doc Link 2982673 Disease Relevance 0.27 Pain Relevance 0.10
Angiotensin II receptors are upregulated by estradiol and progesterone in the locus coeruleus, median preoptic nucleus and subfornical organ of ovariectomized rats.
Positive_regulation (upregulated) of Angiotensin II in locus coeruleus associated with anesthesia and locus ceruleus
8) Confidence 0.69 Published 2005 Journal Brain Res. Section Title Doc Link 16297888 Disease Relevance 0.06 Pain Relevance 0.32
In conclusion, these results show that Ang II receptors are upregulated by E(2) and P in the LC, MnPO and SFO of ovariectomized rats.
Positive_regulation (upregulated) of Ang II in MnPO associated with locus ceruleus
9) Confidence 0.69 Published 2005 Journal Brain Res. Section Abstract Doc Link 16297888 Disease Relevance 0.08 Pain Relevance 0.31
The main features of Bartter's syndrome are growth retardation, hypertrophy, and hyperplasia of the juxtaglomerular apparatus, increased angiotensin II, hyperaldosteronism, hypokalemic alkalosis, normal blood pressure, and decreased response to pressors.
Positive_regulation (increased) of angiotensin II in blood associated with alkalosis, hypertrophy, hypokalemia, hyperaldosteronism, syndrome and hyperplasia
10) Confidence 0.67 Published 1993 Journal AANA J Section Abstract Doc Link 8379280 Disease Relevance 1.05 Pain Relevance 0.15
Increased blood pressure and dipsogenic sensitivity to administration of angiotensin II (Ang II) have been demonstrated during the first 3 weeks of exposure to cold suggesting an upregulation of Ang II receptors when PRA is elevated.
Positive_regulation (upregulation) of Ang II in blood associated with pressure and volume under development
11) Confidence 0.67 Published 1997 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 9100955 Disease Relevance 1.07 Pain Relevance 0.08
Presumably, this can increase the amount of Ang II locally produced in the carotid body, which in turn causes an elevated level of Ang IV for the activation of intracellular signaling cascade leading to the [Ca2+]i elevation.
Positive_regulation (increase) of Ang II in carotid body
12) Confidence 0.67 Published 2007 Journal The open cardiovascular medicine journal Section Body Doc Link PMC2570565 Disease Relevance 0.74 Pain Relevance 0.03
Hence, hypoxia induces an upregulation of the expression of AT4 receptors in the glomus cells of the carotid body with an increase in the Ang IV-induced [Ca2+]i elevation.
Positive_regulation (increase) of Ang IV-induced in glomus associated with hypoxia
13) Confidence 0.67 Published 2007 Journal The open cardiovascular medicine journal Section Abstract Doc Link PMC2570565 Disease Relevance 0.58 Pain Relevance 0
The effect of leucine5-enkephalin (Leu-enkephalin) administered into the lateral (LV) or fourth (4V) cerebroventricle on angiotensin II (ANG II)-stimulated increase in blood pressure, plasma vasopressin concentration ([AVP]), and drinking behavior was determined in conscious rats.
Positive_regulation (increase) of ANG in plasma associated with pressure and volume under development and enkephalin
14) Confidence 0.67 Published 1983 Journal Am. J. Physiol. Section Abstract Doc Link 6340533 Disease Relevance 0.10 Pain Relevance 0.44
The effect of leucine5-enkephalin (Leu-enkephalin) administered into the lateral (LV) or fourth (4V) cerebroventricle on angiotensin II (ANG II)-stimulated increase in blood pressure, plasma vasopressin concentration ([AVP]), and drinking behavior was determined in conscious rats.
Positive_regulation (increase) of angiotensin II in plasma associated with pressure and volume under development and enkephalin
15) Confidence 0.67 Published 1983 Journal Am. J. Physiol. Section Abstract Doc Link 6340533 Disease Relevance 0.10 Pain Relevance 0.44
The effect of intracerebroventricular (i.c.v.) administration of leumorphin on basal blood pressure and angiotensin II (AII)-stimulated increase in blood pressure was examined in conscious unrestrained rats.
Positive_regulation (increase) of angiotensin II in blood associated with pressure and volume under development and intracerebroventricular
16) Confidence 0.66 Published 1986 Journal NIDA Res. Monogr. Section Abstract Doc Link 3123970 Disease Relevance 0.18 Pain Relevance 0.05
L-NAME or 7-nitroindazole enhanced the angiotensin II pressor effect (P < 0.05).
Positive_regulation (enhanced) of angiotensin II
17) Confidence 0.65 Published 2007 Journal Anesth. Analg. Section Body Doc Link 17959957 Disease Relevance 0 Pain Relevance 0
Enalaprilat resulted in a significant increase in plasma Ang I from 133+/-21 to 1167+/-328 pmol/L and a decrease in plasma Ang II from 110+/-12 to 67+/-9 pmol/L.
Positive_regulation (increase) of Ang I in plasma
18) Confidence 0.61 Published 2002 Journal Hypertension Section Abstract Doc Link 11799091 Disease Relevance 0.06 Pain Relevance 0
As previously seen with 5-HT agonists, the efficacy of PAT for displacing [3H]5-HT bound to hippocampal membranes was markedly increased by Mn2+ (1 mM) and reduced by GTP (0.1 mM).
Positive_regulation (increased) of PAT associated with heart rate under development and agonist
19) Confidence 0.60 Published 1984 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6203761 Disease Relevance 0.65 Pain Relevance 0.20
In suckling rats, indomethacin suppressed PGE(2) and COX-2 expression, and increased PGF(2alpha), whereas ibuprofen increased COX-2 and angiotensin II.
Positive_regulation (increased) of angiotensin II
20) Confidence 0.59 Published 2008 Journal Prostaglandins Other Lipid Mediat. Section Abstract Doc Link 18096423 Disease Relevance 0.07 Pain Relevance 0.10

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