INT390

Context Info Confidence 0.70 First Reported 1975 Last Reported 2011 Negated 5 Speculated 6 Reported most in Abstract Documents 170 Total Number 177 Disease Relevance 61.47 Pain Relevance 36.08

extracellular space (Agt) aging (Agt) extracellular region (Agt) extracellular matrix organization (Agt)

Anatomy Link Frequency plasma 19 blood 8 nucleus 6 myocytes 5 kidney 4 Agt (Rattus norvegicus)

Pain Link Frequency Relevance Heat anesthesia 129 100.00 Clonidine 41 100.00 noradrenaline 37 100.00 Kinase C 20 100.00 Opioid 20 100.00 Potency 10 100.00 Antinociceptive 6 99.98 substance P 25 99.96 Intracerebroventricular 17 99.96 cINOD 12 99.96

Disease Link Frequency Relevance Heat Hypertension 1039 100.00 Pressure And Volume Under Development 116 100.00 Heart Rate Under Development 105 100.00 Hyperphagia 4 100.00 Heart Arrhythmia 861 99.96 Insulin Resistance 30 99.96 Hyperaldosteronism 1 99.92 Increased Venous Pressure Under Development 84 99.76 Chronic Renal Failure 537 99.74 INFLAMMATION 339 99.72

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

(I.O.D.) of the hybridized dots revealed a 1-fold and 8-fold increase in Ang mNRA in rats receiving morphine injection for 1 and 4 days, respectively, and a 5-fold and 13-fold increase in rats receiving 3 and 6h EA stimulation, respectively.

Positive_regulation (increase) of Ang mNRA associated with electroacupuncture and morphine

1) Confidence 0.70 Published 1989 Journal Sheng Li Xue Bao Section Abstract Doc Link 2781313 Disease Relevance 0 Pain Relevance 0.77

Autoradiographic examination revealed a marked increase in Ang mRNA in rats receiving multiple injections of morphine or continuous electroacupuncture (EA) stimulation for several hours.

Positive_regulation (increase) of Ang mRNA associated with electroacupuncture and morphine

2) Confidence 0.70 Published 1989 Journal Sheng Li Xue Bao Section Abstract Doc Link 2781313 Disease Relevance 0 Pain Relevance 0.74

Using microbore high-performance liquid chromatography, we determined the concentrations of adenosine in plasma samples collected from (a) the left ventricle and jugular vein of anesthetized rats during acute intravenous infusions of angiotensin II (1, 10, and 100 ng/min) and (b) the carotid artery of conscious, unrestrained rats exposed to chronic elevations of either exogenous angiotensin II (intraperitoneal infusion of angiotensin II, 125 ng/min) or endogenous angiotensin II (induction of renovascular hypertension by clipping the left renal artery or by ligating the suprarenal aorta).

Positive_regulation (elevations) of angiotensin II in carotid artery associated with adenocard and hypertension

3) Confidence 0.69 Published 1991 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 1714001 Disease Relevance 0.15 Pain Relevance 0.32

Using microbore high-performance liquid chromatography, we determined the concentrations of adenosine in plasma samples collected from (a) the left ventricle and jugular vein of anesthetized rats during acute intravenous infusions of angiotensin II (1, 10, and 100 ng/min) and (b) the carotid artery of conscious, unrestrained rats exposed to chronic elevations of either exogenous angiotensin II (intraperitoneal infusion of angiotensin II, 125 ng/min) or endogenous angiotensin II (induction of renovascular hypertension by clipping the left renal artery or by ligating the suprarenal aorta).

Positive_regulation (induction) of angiotensin II in carotid artery associated with adenocard and hypertension

4) Confidence 0.69 Published 1991 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 1714001 Disease Relevance 0.15 Pain Relevance 0.29

During enalaprilat infusion, interstitial fluid concentration of Ang I was significantly increased from 0.78+/-0.06 to 0.97+/-0.08 nmol/L; however, Ang II concentrations were not altered significantly (3.67+/-0.28 versus 3.67+/-0.25 nmol/L).

Positive_regulation (increased) of Ang I

5) Confidence 0.69 Published 2002 Journal Hypertension Section Abstract Doc Link 11799091 Disease Relevance 0.08 Pain Relevance 0

The present results show it to be a competitive antagonist also in vivo since pA2 values are similar, always reaches a 100% response on increasing the Angiotensin II dose, and when relating log (DR-1) and log dose of agonist, the slope is very near to one (0.925).

Positive_regulation (increasing) of Angiotensin II associated with antagonist and agonist

6) Confidence 0.69 Published 1987 Journal Rev. Esp. Fisiol. Section Abstract Doc Link 3616115 Disease Relevance 0 Pain Relevance 0.14

Experimental study in 156 white rats with renovascular hypertension, posthemorrhagic hypotension and with normal blood pressure revealed that high--ressure oxygen (303.9 kPa--50 min) could activate angiotensin--converting enzyme, the latter taking part in inactivation of endogenous opioid peptides.

Positive_regulation (activate) of angiotensin in blood associated with pressure volume 2 under development, hypertension and endogenous opioid

7) Confidence 0.69 Published 1985 Journal Fiziol Zh SSSR Im I M Sechenova Section Abstract Doc Link 2982673 Disease Relevance 0.27 Pain Relevance 0.10

Angiotensin II receptors are upregulated by estradiol and progesterone in the locus coeruleus, median preoptic nucleus and subfornical organ of ovariectomized rats.

Positive_regulation (upregulated) of Angiotensin II in locus coeruleus associated with anesthesia and locus ceruleus

8) Confidence 0.69 Published 2005 Journal Brain Res. Section Title Doc Link 16297888 Disease Relevance 0.06 Pain Relevance 0.32

In conclusion, these results show that Ang II receptors are upregulated by E(2) and P in the LC, MnPO and SFO of ovariectomized rats.

Positive_regulation (upregulated) of Ang II in MnPO associated with locus ceruleus

9) Confidence 0.69 Published 2005 Journal Brain Res. Section Abstract Doc Link 16297888 Disease Relevance 0.08 Pain Relevance 0.31

The main features of Bartter's syndrome are growth retardation, hypertrophy, and hyperplasia of the juxtaglomerular apparatus, increased angiotensin II, hyperaldosteronism, hypokalemic alkalosis, normal blood pressure, and decreased response to pressors.

Positive_regulation (increased) of angiotensin II in blood associated with alkalosis, hypertrophy, hypokalemia, hyperaldosteronism, syndrome and hyperplasia

10) Confidence 0.67 Published 1993 Journal AANA J Section Abstract Doc Link 8379280 Disease Relevance 1.05 Pain Relevance 0.15

Increased blood pressure and dipsogenic sensitivity to administration of angiotensin II (Ang II) have been demonstrated during the first 3 weeks of exposure to cold suggesting an upregulation of Ang II receptors when PRA is elevated.

Positive_regulation (upregulation) of Ang II in blood associated with pressure and volume under development

11) Confidence 0.67 Published 1997 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 9100955 Disease Relevance 1.07 Pain Relevance 0.08

Presumably, this can increase the amount of Ang II locally produced in the carotid body, which in turn causes an elevated level of Ang IV for the activation of intracellular signaling cascade leading to the [Ca2+]i elevation.

Positive_regulation (increase) of Ang II in carotid body

12) Confidence 0.67 Published 2007 Journal The open cardiovascular medicine journal Section Body Doc Link PMC2570565 Disease Relevance 0.74 Pain Relevance 0.03

Hence, hypoxia induces an upregulation of the expression of AT4 receptors in the glomus cells of the carotid body with an increase in the Ang IV-induced [Ca2+]i elevation.

Positive_regulation (increase) of Ang IV-induced in glomus associated with hypoxia

13) Confidence 0.67 Published 2007 Journal The open cardiovascular medicine journal Section Abstract Doc Link PMC2570565 Disease Relevance 0.58 Pain Relevance 0

The effect of leucine5-enkephalin (Leu-enkephalin) administered into the lateral (LV) or fourth (4V) cerebroventricle on angiotensin II (ANG II)-stimulated increase in blood pressure, plasma vasopressin concentration ([AVP]), and drinking behavior was determined in conscious rats.

Positive_regulation (increase) of ANG in plasma associated with pressure and volume under development and enkephalin

14) Confidence 0.67 Published 1983 Journal Am. J. Physiol. Section Abstract Doc Link 6340533 Disease Relevance 0.10 Pain Relevance 0.44

The effect of leucine5-enkephalin (Leu-enkephalin) administered into the lateral (LV) or fourth (4V) cerebroventricle on angiotensin II (ANG II)-stimulated increase in blood pressure, plasma vasopressin concentration ([AVP]), and drinking behavior was determined in conscious rats.

Positive_regulation (increase) of angiotensin II in plasma associated with pressure and volume under development and enkephalin

15) Confidence 0.67 Published 1983 Journal Am. J. Physiol. Section Abstract Doc Link 6340533 Disease Relevance 0.10 Pain Relevance 0.44

The effect of intracerebroventricular (i.c.v.) administration of leumorphin on basal blood pressure and angiotensin II (AII)-stimulated increase in blood pressure was examined in conscious unrestrained rats.

Positive_regulation (increase) of angiotensin II in blood associated with pressure and volume under development and intracerebroventricular

16) Confidence 0.66 Published 1986 Journal NIDA Res. Monogr. Section Abstract Doc Link 3123970 Disease Relevance 0.18 Pain Relevance 0.05

L-NAME or 7-nitroindazole enhanced the angiotensin II pressor effect (P < 0.05).

Positive_regulation (enhanced) of angiotensin II

17) Confidence 0.65 Published 2007 Journal Anesth. Analg. Section Body Doc Link 17959957 Disease Relevance 0 Pain Relevance 0

Enalaprilat resulted in a significant increase in plasma Ang I from 133+/-21 to 1167+/-328 pmol/L and a decrease in plasma Ang II from 110+/-12 to 67+/-9 pmol/L.

Positive_regulation (increase) of Ang I in plasma

18) Confidence 0.61 Published 2002 Journal Hypertension Section Abstract Doc Link 11799091 Disease Relevance 0.06 Pain Relevance 0

As previously seen with 5-HT agonists, the efficacy of PAT for displacing [3H]5-HT bound to hippocampal membranes was markedly increased by Mn2+ (1 mM) and reduced by GTP (0.1 mM).

Positive_regulation (increased) of PAT associated with heart rate under development and agonist

19) Confidence 0.60 Published 1984 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6203761 Disease Relevance 0.65 Pain Relevance 0.20

In suckling rats, indomethacin suppressed PGE(2) and COX-2 expression, and increased PGF(2alpha), whereas ibuprofen increased COX-2 and angiotensin II.

Positive_regulation (increased) of angiotensin II

20) Confidence 0.59 Published 2008 Journal Prostaglandins Other Lipid Mediat. Section Abstract Doc Link 18096423 Disease Relevance 0.07 Pain Relevance 0.10

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