INT39008

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Context Info
Confidence 0.77
First Reported 1985
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 16
Disease Relevance 9.07
Pain Relevance 2.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (App) Golgi apparatus (App) plasma membrane (App)
extracellular matrix organization (App) DNA binding (App) cytoplasm (App)
Anatomy Link Frequency
brain 4
astrocytes 4
SH-SY5Y 1
neurons 1
cleavage 1
App (Rattus norvegicus)
Pain Link Frequency Relevance Heat
depression 50 99.88 Very High Very High Very High
Kinase C 2 97.36 Very High Very High Very High
sSRI 192 96.68 Very High Very High Very High
cINOD 9 96.28 Very High Very High Very High
Abeta 3 93.40 High High
5HT 36 86.44 High High
Inflammation 3 83.32 Quite High
Gabapentin 4 83.08 Quite High
bradykinin 1 80.40 Quite High
Neurotransmitter 4 69.76 Quite High
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 39 100.00 Very High Very High Very High
Depression 60 99.88 Very High Very High Very High
Syndrome 486 99.36 Very High Very High Very High
Parkinson's Disease 20 98.84 Very High Very High Very High
Stress 22 98.50 Very High Very High Very High
Asthma 22 97.92 Very High Very High Very High
Neuroblastoma 1 96.08 Very High Very High Very High
Disease 288 94.32 High High
Toxicity 3 93.76 High High
Amyloid Plaque 10 93.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study we examined the question whether cholinesterase inhibitors (ChEI) could alter the release of amyloid precursor protein (APP) from superfused brain cortical slices of the rat following electrical as well as pharmacological stimulation with bethanechol (BETHA).
Localization (release) of APP in brain associated with alzheimer's dementia
1) Confidence 0.77 Published 1996 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 8624119 Disease Relevance 0.10 Pain Relevance 0
In this study we examined the question whether cholinesterase inhibitors (ChEI) could alter the release of amyloid precursor protein (APP) from superfused brain cortical slices of the rat following electrical as well as pharmacological stimulation with bethanechol (BETHA).
Localization (release) of amyloid precursor protein in brain associated with alzheimer's dementia
2) Confidence 0.77 Published 1996 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 8624119 Disease Relevance 0.10 Pain Relevance 0
This indicates that they capture some aspects that are important for the reporting of APP.
Localization (reporting) of APP
3) Confidence 0.75 Published 2008 Journal Environ Health Section Body Doc Link PMC2289819 Disease Relevance 0.08 Pain Relevance 0.04
We examined whether cholinesterase inhibitors (ChEI) could alter the release of amyloid precursor protein (APP) from superfused brain cortical slices of the rat.
Localization (release) of amyloid precursor protein in brain associated with alzheimer's dementia
4) Confidence 0.74 Published 1995 Journal Neuroreport Section Abstract Doc Link 7605915 Disease Relevance 0.10 Pain Relevance 0
We examined whether cholinesterase inhibitors (ChEI) could alter the release of amyloid precursor protein (APP) from superfused brain cortical slices of the rat.
Localization (release) of APP in brain associated with alzheimer's dementia
5) Confidence 0.74 Published 1995 Journal Neuroreport Section Abstract Doc Link 7605915 Disease Relevance 0.10 Pain Relevance 0
The new variables were all significantly associated with APP, indicating that dwelling factors (type of dwelling, damp, draughts or cold in the home and other forms of poor indoor climate) and depression were important for APP.
Localization (important) of APP associated with depression
6) Confidence 0.65 Published 2008 Journal Environ Health Section Body Doc Link PMC2289819 Disease Relevance 0.58 Pain Relevance 0.13
Concomitantly, their activation decreases the formation of both secreted soluble beta A4 and of endosomal-lysosomal C-terminal APP derivatives.
Localization (secreted) of APP
7) Confidence 0.57 Published 1994 Journal J. Neural Transm. Suppl. Section Abstract Doc Link 7897393 Disease Relevance 0.40 Pain Relevance 0.18
In addition, IBU-PO enhances, dose-dependently, the non-amyloidogenic amyloid precursor protein (APP) cleavage by increasing secreted APP and decreasing endogenous Abeta1-40 in rat hippocampal neurons.
Localization (secreted) of APP in cleavage associated with alzheimer's dementia
8) Confidence 0.54 Published 2005 Journal Neurobiol. Dis. Section Abstract Doc Link 15649708 Disease Relevance 0.64 Pain Relevance 0.31
Pakaski et al (2005) report an increase in APP secretion resulting from in vitro treatment of rat basal forebrain neurons with a different SSRI, citalopram, but the benefit of this result seems counterintuitive.
Localization (secretion) of APP in neurons associated with ssri
9) Confidence 0.29 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656299 Disease Relevance 0.40 Pain Relevance 0.27
The ectodomain portion of APP shunts more of the APP away from the ?
Localization (more) of APP
10) Confidence 0.27 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656299 Disease Relevance 1.28 Pain Relevance 0.40
In DS astrocytes, energy depletion leads to abnormal APP metabolism and altered APP secretion, both of which can be prevented by treatment with antioxidants [22].
Localization (secretion) of APP in astrocytes associated with syndrome
11) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2996288 Disease Relevance 0.68 Pain Relevance 0.08
Our previous research indicates the presence of mitochondrial dysfunction and energy deficits in DS astrocytes leading to abnormal amyloid precursor protein (APP) processing and secretion, and to intracellular accumulation of amyloid ?
Localization (secretion) of APP in astrocytes associated with parkinson's disease, syndrome and alzheimer's dementia
12) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2996288 Disease Relevance 1.09 Pain Relevance 0
Our previous research indicates the presence of mitochondrial dysfunction and energy deficits in DS astrocytes leading to abnormal amyloid precursor protein (APP) processing and secretion, and to intracellular accumulation of amyloid ?
Localization (secretion) of amyloid precursor protein in astrocytes associated with parkinson's disease, syndrome and alzheimer's dementia
13) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2996288 Disease Relevance 1.15 Pain Relevance 0
Astrocytes from DS fetal brain tissue and DS mouse models show increased concentration of intracellular calcium [55], [56], altered sensitivity to oxidative stress [57], deficits in mitochondrial energy metabolism [22], [58] and abnormal APP transport and secretion [22].
Localization (secretion) of APP in Astrocytes associated with stress and syndrome
14) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2996288 Disease Relevance 1.58 Pain Relevance 0
The inhibitor of hepatic lipoprotein release, 4-aminopyrazolo-(3,4-d)-pyrimidine (4-APP), has been shown to reduce testosterone production via impairment of pituitary gonadotropin secretion rather than through decreased cholesterol availability.
Localization (release) of 4-APP in pituitary
15) Confidence 0.08 Published 1985 Journal Endocrinology Section Abstract Doc Link 3886368 Disease Relevance 0.07 Pain Relevance 0
Here we report that various NSAIDs, such as the cyclooxygenase inhibitors, nimesulide, ibuprofen and indomethacin, as well as thalidomide (Thal) and its non-teratogenic analogue, supidimide, significantly stimulated the secretion of the non-amyloidogenic alpha-secretase form of the soluble amyloid precursor protein (sAPP alpha) into the conditioned media of SH-SY5Y neuroblastoma and PC12 cells.
Localization (secretion) of non-amyloidogenic alpha-secretase in SH-SY5Y associated with neuroblastoma, alzheimer's dementia and cinod
16) Confidence 0.01 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 12070143 Disease Relevance 0.71 Pain Relevance 0.63

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