INT39009

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Context Info
Confidence 0.38
First Reported 1985
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 3.37
Pain Relevance 1.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (App) Golgi apparatus (App) plasma membrane (App)
extracellular matrix organization (App) DNA binding (App) cytoplasm (App)
Anatomy Link Frequency
brain 1
pituitary 1
App (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Abeta 1 99.04 Very High Very High Very High
Demyelination 2 97.92 Very High Very High Very High
cINOD 3 97.30 Very High Very High Very High
Kinase C 1 94.84 High High
dexamethasone 4 83.44 Quite High
bradykinin 1 81.36 Quite High
anesthesia 2 77.84 Quite High
metalloproteinase 1 77.36 Quite High
Central nervous system 1 73.56 Quite High
Inflammation 1 72.04 Quite High
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 8 100.00 Very High Very High Very High
Injury 7 99.78 Very High Very High Very High
Disease 7 99.58 Very High Very High Very High
Demyelinating Disease 4 97.92 Very High Very High Very High
INFLAMMATION 3 97.18 Very High Very High Very High
Brain Injury 8 89.20 High High
Multiple Sclerosis 5 84.12 Quite High
Cognitive Disorder 1 80.96 Quite High
Gonadal Disease 1 75.00 Quite High
Central Nervous System Disease 1 73.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Clinical disease correlated with the numbers of APP positive axon spheroids.
Negative_regulation (numbers) of APP associated with disease
1) Confidence 0.38 Published 2006 Journal Acta Neuropathol. Section Abstract Doc Link 16718350 Disease Relevance 1.23 Pain Relevance 0.27
Concomitantly, their activation decreases the formation of both secreted soluble beta A4 and of endosomal-lysosomal C-terminal APP derivatives.
Negative_regulation (derivatives) of APP
2) Confidence 0.33 Published 1994 Journal J. Neural Transm. Suppl. Section Abstract Doc Link 7897393 Disease Relevance 0.39 Pain Relevance 0.18
Both ovariectomized female and male animals treated with progesterone showed a profound reduction in axonal injury (seen via diminished APP immunoreactivity) when compared to controls.
Negative_regulation (diminished) of APP associated with injury
3) Confidence 0.29 Published 2007 Journal Exp. Neurol. Section Abstract Doc Link 17362936 Disease Relevance 0.79 Pain Relevance 0.10
Since administration of anti-inflammatory drugs has been reported to possibly slow the progression of Alzheimer's disease, an effort was made to define effector functions induced by beta-amyloid (A beta) which may be inhibited by these drugs.
Negative_regulation (inhibited) of beta-amyloid associated with inflammation, alzheimer's dementia, cinod and disease
4) Confidence 0.05 Published 1996 Journal Neuroreport Section Abstract Doc Link 9116244 Disease Relevance 0.37 Pain Relevance 0.29
The inhibitor of hepatic lipoprotein release, 4-aminopyrazolo-(3,4-d)-pyrimidine (4-APP), has been shown to reduce testosterone production via impairment of pituitary gonadotropin secretion rather than through decreased cholesterol availability.
Negative_regulation (inhibitor) of 4-APP in pituitary
5) Confidence 0.05 Published 1985 Journal Endocrinology Section Abstract Doc Link 3886368 Disease Relevance 0.07 Pain Relevance 0
The underlying mechanisms for the beneficial effect of these agents are by and large attributed to their ability to reduce beta-amyloid (Abeta) production and amyloid load in the brain, via inhibition of amyloidogenic gamma-secretase activity.
Negative_regulation (inhibition) of amyloidogenic gamma-secretase in brain associated with alzheimer's dementia and abeta
6) Confidence 0.00 Published 2005 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 15850769 Disease Relevance 0.51 Pain Relevance 0.23

General Comments

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