INT39012

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Context Info
Confidence 0.44
First Reported 1985
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.09
Pain Relevance 0.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Rnpep) extracellular space (Rnpep) aging (Rnpep)
extracellular region (Rnpep) Golgi apparatus (Rnpep) plasma membrane (Rnpep)
Anatomy Link Frequency
endocrine cells 1
Rnpep (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 8 100.00 Very High Very High Very High
Opioid 1 93.92 High High
Dynorphin 1 91.36 High High
substance P 1 88.72 High High
Somatostatin 2 88.44 High High
Neuropeptide 3 68.00 Quite High
opiate 1 67.92 Quite High
Inflammation 5 48.00 Quite Low
Glutamate 3 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pheochromocytoma 1 92.64 High High
INFLAMMATION 5 48.00 Quite Low
Cancer 2 44.48 Quite Low
Diabetes Mellitus 1 42.48 Quite Low
Sprains And Strains 3 5.00 Very Low Very Low Very Low
Aids-related Complex 1 5.00 Very Low Very Low Very Low
Nocardia Infection 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Aminopeptidase-B is widely distributed in a number of tissues, including endocrine and non-endocrine cells.
Positive_regulation (distributed) of Aminopeptidase-B in endocrine cells
1) Confidence 0.44 Published 1999 Journal Int. J. Biochem. Cell Biol. Section Abstract Doc Link 10467730 Disease Relevance 0.09 Pain Relevance 0.22
Only aminopeptidase MII hydrolyzed Leu-enkephalin at a significant rate, indicating that this enzyme can account for the membrane-bound enkephalin aminopeptidase activity.
Positive_regulation (account) of aminopeptidase associated with enkephalin
2) Confidence 0.39 Published 1985 Journal J. Neurochem. Section Abstract Doc Link 3886843 Disease Relevance 0 Pain Relevance 0.67
Several recent studies have demonstrated that Ap-B activity occurs in combination with different proteases, such as NRD convertase [15], Cathepsin L [16] and aminopeptidase A [17].
Positive_regulation (occurs) of Ap-B
3) Confidence 0.03 Published 2007 Journal BMC Biochem Section Body Doc Link PMC2241622 Disease Relevance 0 Pain Relevance 0.10

General Comments

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