INT39016

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Context Info
Confidence 0.53
First Reported 1983
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 19
Total Number 20
Disease Relevance 3.92
Pain Relevance 10.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Abat)
Anatomy Link Frequency
thalamus 3
brain 2
medial 1
nucleus 1
lamina 1
Abat (Rattus norvegicus)
Pain Link Frequency Relevance Heat
gABA 157 100.00 Very High Very High Very High
Thalamus 25 99.86 Very High Very High Very High
Inflammation 70 99.72 Very High Very High Very High
Glutamate 26 99.68 Very High Very High Very High
Spinal cord 22 99.68 Very High Very High Very High
Hippocampus 10 99.68 Very High Very High Very High
cytokine 6 99.20 Very High Very High Very High
substance P 10 98.76 Very High Very High Very High
Pain 29 98.74 Very High Very High Very High
Cholecystokinin 17 98.66 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 70 99.72 Very High Very High Very High
Pain 30 98.74 Very High Very High Very High
Inflammatory Pain 15 98.32 Very High Very High Very High
Nociception 40 97.84 Very High Very High Very High
Convulsion 4 95.20 Very High Very High Very High
Urological Neuroanatomy 10 93.08 High High
Stress 6 90.08 High High
Syndrome 1 89.00 High High
Reprotox - General 1 5 88.00 High High
Substance Withdrawal Syndrome 1 85.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Differential expression of GABA(B(1b)) receptor mRNA in the thalamus of normal and monoarthritic animals.
Transcription (expression) of GABA in thalamus associated with gaba and thalamus
1) Confidence 0.53 Published 2004 Journal Biochem. Pharmacol. Section Title Doc Link 15451403 Disease Relevance 0.09 Pain Relevance 0.47
The amount of GABA(B(1b)) mRNA was expressed as times fold of background values.
Transcription (expressed) of GABA associated with gaba
2) Confidence 0.53 Published 2004 Journal Biochem. Pharmacol. Section Abstract Doc Link 15451403 Disease Relevance 0.08 Pain Relevance 0.44
No expression of GABA(B(1b)) mRNA was found in the Rt of control or MA animals.
Transcription (expression) of GABA associated with gaba
3) Confidence 0.53 Published 2004 Journal Biochem. Pharmacol. Section Abstract Doc Link 15451403 Disease Relevance 0.07 Pain Relevance 0.52
In this study, we evaluated whether the expression of GABA(B(1b)) receptor mRNA is regulated supraspinally, namely in the thalamus, as part of the response to chronically enhanced noxious input arising from experimental monoarthritis (MA).
Transcription (expression) of GABA in thalamus associated with gaba and thalamus
4) Confidence 0.53 Published 2004 Journal Biochem. Pharmacol. Section Abstract Doc Link 15451403 Disease Relevance 0.10 Pain Relevance 0.43
No expression of GABA(B(1b)) mRNA was found in the Rt of control or MA animals.
Transcription (found) of GABA associated with gaba
5) Confidence 0.53 Published 2004 Journal Biochem. Pharmacol. Section Abstract Doc Link 15451403 Disease Relevance 0.07 Pain Relevance 0.52
Similarly, GABA(B2) mRNA was not found in the reticular nucleus.
Neg (not) Transcription (found) of GABA in nucleus associated with gaba
6) Confidence 0.53 Published 2006 Journal Brain Res. Bull. Section Abstract Doc Link 17113954 Disease Relevance 0.07 Pain Relevance 0.54
The pain factor is established to be very important for changes in the activity of GABA-transaminase and succinate dehydrogenase.
Transcription (activity) of GABA-transaminase associated with pain and gaba
7) Confidence 0.52 Published 1983 Journal Ukr. Biokhim. Zh. Section Abstract Doc Link 6686357 Disease Relevance 0.59 Pain Relevance 0.62
GABA release and GAD67 mRNA expression in rat hippocampus following entorhinal cortex activation.
Transcription (expression) of GABA in hippocampus associated with gaba and hippocampus
8) Confidence 0.47 Published 1997 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 9332739 Disease Relevance 0 Pain Relevance 0.47
GABA(B(1a)) and GABA(B2) mRNA expression was here determined by in situ hybridisation in the brain of control, 2, 4, 7 and 14 days monoarthritic rats, to evaluate whether this expression was regulated by chronic noxious input in thalamic nuclei. mRNA labelling was analysed quantitatively in the ventrobasal complex, posterior, central medial/central lateral and reticular thalamic nuclei; the thalamic visual relay and dentate gyrus were examined for control.
Transcription (expression) of GABA in brain associated with gaba
9) Confidence 0.46 Published 2006 Journal Brain Res. Bull. Section Abstract Doc Link 17113954 Disease Relevance 0.09 Pain Relevance 0.54
GABA(B(1a)) and GABA(B2) mRNA expression was here determined by in situ hybridisation in the brain of control, 2, 4, 7 and 14 days monoarthritic rats, to evaluate whether this expression was regulated by chronic noxious input in thalamic nuclei. mRNA labelling was analysed quantitatively in the ventrobasal complex, posterior, central medial/central lateral and reticular thalamic nuclei; the thalamic visual relay and dentate gyrus were examined for control.
Transcription (expression) of GABA in brain associated with gaba
10) Confidence 0.46 Published 2006 Journal Brain Res. Bull. Section Abstract Doc Link 17113954 Disease Relevance 0.09 Pain Relevance 0.54
In the thalamus, mRNA expression of the GABA(B(1b)) isoform was shown to be regulated in relay nuclei in response to chronic noxious input arising from experimental monoarthritis.
Transcription (expression) of GABA in thalamus associated with gaba and thalamus
11) Confidence 0.46 Published 2006 Journal Brain Res. Bull. Section Abstract Doc Link 17113954 Disease Relevance 0.10 Pain Relevance 0.46
However, GABA(B2) mRNA expression was observed in the ventrobasal complex, posterior and central medial/central lateral nuclei of control animals.
Transcription (expression) of GABA in medial associated with gaba
12) Confidence 0.46 Published 2006 Journal Brain Res. Bull. Section Abstract Doc Link 17113954 Disease Relevance 0.07 Pain Relevance 0.53
Specifically, this effect was due to reduced levels of 3alpha,5alpha-THP which enhance transcription of the gene encoding the alpha4 subunit of the GABA(A) receptor.
Transcription (transcription) of GABA associated with gaba
13) Confidence 0.39 Published 1998 Journal Nature Section Abstract Doc Link 9582073 Disease Relevance 1.04 Pain Relevance 0.92
These genes encode members of several protein groups, such as GABA synthesis enzymes and receptors, interleukins and their receptors, serotonin, adenosine, ?
Transcription (enzymes) of GABA associated with adenocard, gaba and serotonin
14) Confidence 0.20 Published 2005 Journal Mol Pain Section Body Doc Link PMC1242251 Disease Relevance 0.39 Pain Relevance 0.78
These include genes encoding GAD65 GABA synthesis enzyme, anti-inflammatory cytokine, IL-10, and GABAB1d, A1 adenosine, ?
Transcription (enzyme) of GABA associated with adenocard, gaba, inflammation and cytokine
15) Confidence 0.18 Published 2005 Journal Mol Pain Section Body Doc Link PMC1242251 Disease Relevance 0.64 Pain Relevance 0.69
GABA(A) pi-subunit mRNA abundance was constant throughout gestation, but decreased at the onset of labor.
Transcription (abundance) of GABA associated with gaba
16) Confidence 0.17 Published 2001 Journal Endocrinology Section Abstract Doc Link 11316740 Disease Relevance 0.05 Pain Relevance 0.66
Immunoreactive fibers to cholecystokinin-8, vasoactive intestinal polypeptide and glutamate decarboxylase (gamma-aminobutyrate-synthesizing enzyme, used as a marker of gamma-aminobutyrate) were widely distributed in the spinal cord, being particularly concentrated in the superficial dorsal horn, suggesting a close relationship to the pain transmission system.
Transcription (distributed) of gamma-aminobutyrate-synthesizing enzyme in dorsal horn associated with pain, glutamate, dorsal horn, cholecystokinin and spinal cord
17) Confidence 0.08 Published 1985 Journal Neuroscience Section Abstract Doc Link 3887208 Disease Relevance 0.10 Pain Relevance 0.58
4 subunit of the GABA-A receptor gene (GABA-AR?
Transcription (subunit) of GABA associated with gaba
18) Confidence 0.04 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958627 Disease Relevance 0.06 Pain Relevance 0.22
4 subunit of the GABA-A receptor gene (GABA-AR?
Transcription (subunit) of GABA associated with gaba
19) Confidence 0.04 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958627 Disease Relevance 0.06 Pain Relevance 0.22
GABA-IR elements were also observed in the lamina III.
Transcription (observed) of GABA-IR in lamina associated with gaba
20) Confidence 0.01 Published 1995 Journal Neurosci. Res. Section Abstract Doc Link 8602272 Disease Relevance 0.18 Pain Relevance 0.67

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