INT39040

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Context Info
Confidence 0.51
First Reported 1985
Last Reported 2006
Negated 0
Speculated 1
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.41
Pain Relevance 1.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Gnrh1) extracellular region (Gnrh1) molecular_function (Gnrh1)
Anatomy Link Frequency
brain 2
LH (Rattus norvegicus)
Gnrh1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
narcan 23 99.78 Very High Very High Very High
Morphine 3 92.12 High High
antagonist 3 79.32 Quite High
Opioid 3 78.88 Quite High
Endogenous opioid 1 40.88 Quite Low
Enkephalin 2 27.04 Quite Low
opioid receptor 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Stress 8 99.46 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The same stress conditions did not affect LH-releasing hormone (LHRH)-induced LH release, suggesting that the stress-related suppression of the naloxone-induced LH release was a suprapituitary event.
LH Positive_regulation (induced) of Localization (release) of LHRH associated with stress and narcan
1) Confidence 0.51 Published 1998 Journal J. Neuroendocrinol. Section Abstract Doc Link 9535053 Disease Relevance 0.41 Pain Relevance 0.49
Since we observed no competition between LHRH and naloxone for their binding sites in pituitary or brain, the only viable interpretation of our results is that naloxone increases LH by inducing the release of LHRH.
LH Positive_regulation (inducing) of Localization (release) of LHRH in brain associated with narcan
2) Confidence 0.38 Published 1985 Journal Life Sci. Section Abstract Doc Link 3894852 Disease Relevance 0 Pain Relevance 0.63
The action of leptin appears to be mediated by changes in GnRH and LH secretion as well as NPY immunoreactivity.
LH Spec (appears) Positive_regulation (mediated) of Localization (secretion) of GnRH
3) Confidence 0.14 Published 2006 Journal Reprod Biol Section Abstract Doc Link 16967091 Disease Relevance 0 Pain Relevance 0

General Comments

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