INT39046

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Context Info
Confidence 0.69
First Reported 1985
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 28
Total Number 29
Disease Relevance 18.18
Pain Relevance 13.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (PTGER1) signal transducer activity (PTGER1)
Anatomy Link Frequency
macrophages 4
SH-SY5Y 1
structural cells 1
blood 1
spinal 1
PTGER1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 118 100.00 Very High Very High Very High
Potency 10 99.96 Very High Very High Very High
Peripheral nerve injury 39 99.92 Very High Very High Very High
Abeta 7 99.84 Very High Very High Very High
Immobilon 8 99.76 Very High Very High Very High
Kinase C 6 99.34 Very High Very High Very High
Migraine 6 99.28 Very High Very High Very High
Inflammation 261 99.16 Very High Very High Very High
aspirin 11 99.12 Very High Very High Very High
Glutamate 8 99.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nervous System Injury 355 99.92 Very High Very High Very High
Cancer 68 99.42 Very High Very High Very High
Headache 8 99.28 Very High Very High Very High
INFLAMMATION 332 99.16 Very High Very High Very High
Hyperalgesia 103 99.06 Very High Very High Very High
Non-small-cell Lung Cancer 29 98.72 Very High Very High Very High
Atherosclerosis 8 98.64 Very High Very High Very High
Injury 235 98.30 Very High Very High Very High
Hypersensitivity 43 97.82 Very High Very High Very High
Pain 249 97.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The purpose of this study was to determine whether acid-induced pain hypersensitivity within the non-acid-exposed esophagus (secondary hyperalgesia) is mediated by PGE(2) activation of the EP-1 receptor.
Positive_regulation (activation) of EP-1 receptor in esophagus associated with hyperalgesia, hypersensitivity and stimulus evoked pain
1) Confidence 0.69 Published 2003 Journal Gastroenterology Section Abstract Doc Link 12512025 Disease Relevance 0.54 Pain Relevance 0.61
The molecular regulators of EP1 expression in DRG neurons are unknown – trauma and initial inflammatory response (shown by rapid increases of CD68-IR) may lead to increased EP1 levels, to which PGs may contribute.
Positive_regulation (increased) of EP1 in neurons associated with inflammatory response and injury
2) Confidence 0.50 Published 2006 Journal BMC Neurol Section Body Doc Link PMC1361784 Disease Relevance 0.86 Pain Relevance 0.68
The greater increase distally of EP1 was a trend, and not statistically significant, and could be the result of increased EP1 in regenerating or spared fibres.
Positive_regulation (increased) of EP1
3) Confidence 0.50 Published 2006 Journal BMC Neurol Section Body Doc Link PMC1361784 Disease Relevance 0.56 Pain Relevance 0.38
After defining the structural requirements for EP1 potency and selectivity, heterocyclic rings were incorporated to reduce logD and improve in vitro pharmacokinetic properties.
Positive_regulation (requirements) of EP1 associated with potency
4) Confidence 0.49 Published 2007 Journal Bioorg. Med. Chem. Lett. Section Abstract Doc Link 17084082 Disease Relevance 0.07 Pain Relevance 0.32
The greater increase distally of EP1 was a trend, and not statistically significant, and could be the result of increased EP1 in regenerating or spared fibres.
Positive_regulation (increase) of EP1
5) Confidence 0.36 Published 2006 Journal BMC Neurol Section Body Doc Link PMC1361784 Disease Relevance 0.58 Pain Relevance 0.40
Sensory neurones in injured human DRG showed a significant acute increase of EP1-IR intensity.
Positive_regulation (increase) of EP1
6) Confidence 0.34 Published 2006 Journal BMC Neurol Section Abstract Doc Link PMC1361784 Disease Relevance 1.06 Pain Relevance 0.32
In this study, we report that a rapid increase of EP1 receptor levels in injured human sensory neurones preceded Cox-2 expression in infiltrating macrophages.
Positive_regulation (increase) of EP1 in macrophages
7) Confidence 0.34 Published 2006 Journal BMC Neurol Section Body Doc Link PMC1361784 Disease Relevance 1.14 Pain Relevance 1.36
EP1 receptor level increase in sensory neurones, and macrophage infiltration, appears to precede increased Cox-2 expression by macrophages.
Positive_regulation (increase) of EP1 in macrophage
8) Confidence 0.34 Published 2006 Journal BMC Neurol Section Abstract Doc Link PMC1361784 Disease Relevance 0.78 Pain Relevance 0.29
EP1 receptor levels were reported for the first time in human nerve fibres and DRG, and appeared increased in acutely injured tissues.
Positive_regulation (increased) of EP1 in nerve
9) Confidence 0.34 Published 2006 Journal BMC Neurol Section Body Doc Link PMC1361784 Disease Relevance 0.61 Pain Relevance 0.49
While there was a rapid increase in EP1-fibres and CD-68 positive macrophages, Cox-2 increase was apparent later, but was persistent in human painful neuromas for years.
Positive_regulation (increase) of EP1 in macrophages associated with pain and neuroma
10) Confidence 0.29 Published 2006 Journal BMC Neurol Section Abstract Doc Link PMC1361784 Disease Relevance 1.00 Pain Relevance 0.28
EP1:NF ratio was significantly increased in human brachial plexus nerve fibres, both proximal and distal to injury, in comparison with uninjured nerves.
Positive_regulation (increased) of EP1 in proximal associated with injury
11) Confidence 0.29 Published 2006 Journal BMC Neurol Section Abstract Doc Link PMC1361784 Disease Relevance 1.10 Pain Relevance 0.28
Increased inflammation was associated with unchanged PGF levels, resulting in an increased ratio of PGE/PGF with increasing inflammation.
Positive_regulation (increased) of PGE associated with inflammation
12) Confidence 0.29 Published 1985 Journal Dig. Dis. Sci. Section Abstract Doc Link 3896701 Disease Relevance 0.97 Pain Relevance 0.49
EP1/3 agonist stimulates and EP2/4 agonists compromise proliferation of Lovo cells
Positive_regulation (stimulates) of EP1 associated with agonist
13) Confidence 0.29 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2615781 Disease Relevance 0.08 Pain Relevance 0.38
In particular, the clear effect of the highly specific reagent PTX strongly argued for the involvement of the Gi-coupled prostanoid receptor EP3.


Positive_regulation (coupled) of prostanoid receptor
14) Confidence 0.25 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2615781 Disease Relevance 0.08 Pain Relevance 0.21
More recently, a study comparing EP receptor expression in nasal biopsies from aspirin intolerant and tolerant patients showed an up-regulation of EP1 and EP2 in structural cells from aspirin intolerant subjects [15].
Positive_regulation (up) of EP1 in structural cells associated with aspirin
15) Confidence 0.21 Published 2006 Journal Respir Res Section Body Doc Link PMC1481584 Disease Relevance 0.72 Pain Relevance 0.34
PGE may be elevated in patients with migraine.
Spec (may) Positive_regulation (elevated) of PGE associated with migraine
16) Confidence 0.19 Published 1985 Journal Cephalalgia Section Abstract Doc Link 4016946 Disease Relevance 1.01 Pain Relevance 0.80
Several mechanisms have been proposed, including EP1 receptor activation and spinal release of glutamate as well as loss of spinal glycine receptor mediated inhibition [59].
Positive_regulation (activation) of EP1 receptor in spinal associated with glutamate
17) Confidence 0.17 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206352 Disease Relevance 0.69 Pain Relevance 1.35
PGE2 are mediated through one or more of its receptors: EP1, EP2,
Positive_regulation (mediated) of EP1
18) Confidence 0.15 Published 2008 Journal PPAR Research Section Body Doc Link PMC2515882 Disease Relevance 0.52 Pain Relevance 0.03
Chronic exposure of all-trans-retinoic acid-differentiated SH-SY5Y cells to morphine (10 mu M; 2 days) results in sensitization of adenylate cyclase as characterized by a significant increase in both PGE1 receptor-mediated as well as receptor-independent (NaF, 10 mM; forskolin, 100 mu M) stimulation of effector activity.
Positive_regulation (increase) of PGE1 receptor in SH-SY5Y associated with morphine
19) Confidence 0.14 Published 1996 Journal Brain Res. Section Abstract Doc Link 8919301 Disease Relevance 0.15 Pain Relevance 0.37
We found an association between increased PGE(2) and increasing number of cardiovascular risk factors and carotid intima-media thickness, a noninvasive surrogate marker of atherosclerosis, independently of traditional and non traditional cardiovascular risk factors.
Positive_regulation (increased) of PGE associated with atherosclerosis
20) Confidence 0.10 Published 2005 Journal Curr Drug Targets Cardiovasc Haematol Disord Section Abstract Doc Link 16101563 Disease Relevance 1.28 Pain Relevance 0.20

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