INT39048

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Context Info
Confidence 0.45
First Reported 1985
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.55
Pain Relevance 1.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (PTGER1) signal transducer activity (PTGER1)
Anatomy Link Frequency
neurons 2
muscle 2
PTGER1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 23 99.76 Very High Very High Very High
agonist 18 99.16 Very High Very High Very High
Inflammatory response 3 98.04 Very High Very High Very High
Inflammation 24 97.88 Very High Very High Very High
Bioavailability 1 92.08 High High
Sciatic nerve 12 86.44 High High
Neuropathic pain 9 76.20 Quite High
Spinal cord 16 69.08 Quite High
Dorsal horn 9 68.32 Quite High
cINOD 9 50.08 Quite High
Disease Link Frequency Relevance Heat
Pain 18 99.76 Very High Very High Very High
Colorectal Cancer 36 99.48 Very High Very High Very High
Injury 25 98.80 Very High Very High Very High
INFLAMMATION 30 98.04 Very High Very High Very High
Cholecystitis 5 95.84 Very High Very High Very High
Neuropathic Pain 15 76.20 Quite High
Wallerian Degeneration 1 73.44 Quite High
Colon Cancer 1 72.72 Quite High
Neuroma 12 63.44 Quite High
Nervous System Injury 38 55.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The molecular regulators of EP1 expression in DRG neurons are unknown – trauma and initial inflammatory response (shown by rapid increases of CD68-IR) may lead to increased EP1 levels, to which PGs may contribute.
Regulation (regulators) of Gene_expression (expression) of EP1 in neurons associated with inflammatory response and injury
1) Confidence 0.45 Published 2006 Journal BMC Neurol Section Body Doc Link PMC1361784 Disease Relevance 0.77 Pain Relevance 0.59
Thus, the observed altered expression of EP receptor subtypes in CRC patients compared to non-CRC subjects does not seem to be manifest in the functionality of the receptors in epithelial transport.
Regulation (altered) of Gene_expression (expression) of EP receptor associated with colorectal cancer
2) Confidence 0.20 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2824707 Disease Relevance 0.70 Pain Relevance 0.17
However, there was poor correlation between pain relief and changes in PGE production by gallbladder mucosa and muscle.
Regulation (changes) of Gene_expression (production) of PGE in muscle associated with pain
3) Confidence 0.17 Published 1985 Journal Dig. Dis. Sci. Section Abstract Doc Link 3896701 Disease Relevance 1.08 Pain Relevance 0.55

General Comments

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