INT3905

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Context Info
Confidence 0.27
First Reported 1977
Last Reported 2011
Negated 0
Speculated 2
Reported most in Abstract
Documents 10
Total Number 12
Disease Relevance 1.76
Pain Relevance 5.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Rtcd1) molecular_function (Rtcd1) ligase activity (Rtcd1)
Anatomy Link Frequency
neurons 2
spinal cord 2
tail 2
platelet 2
Rtcd1 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 14 100.00 Very High Very High Very High
noradrenaline 6 100.00 Very High Very High Very High
Catecholamine 1 100.00 Very High Very High Very High
nMDA receptor 2 99.88 Very High Very High Very High
action potential duration 4 99.66 Very High Very High Very High
Dopamine 5 99.56 Very High Very High Very High
Spinal cord 2 99.56 Very High Very High Very High
agonist 12 99.28 Very High Very High Very High
Pain 4 99.16 Very High Very High Very High
addiction 11 98.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Vibrio Infection 3 99.84 Very High Very High Very High
Nociception 6 98.72 Very High Very High Very High
Obesity 6 96.72 Very High Very High Very High
Drug Dependence 2 88.80 High High
Cv General 3 Under Development 1 86.20 High High
Bordatella Infection 4 85.36 High High
Targeted Disruption 1 79.60 Quite High
Glioma 1 73.48 Quite High
Neuroblastoma 1 73.12 Quite High
Pain 2 64.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An enhanced response of the NA-sensitive adenylate cyclase to 1-NA(10-5 M), in comparison to control mice, was demonstrated after treatments producing a chronic reduction in stimulation of alpha-adrenergic receptors (phenoxybenzamine 10 mg/kg per day), beta-adrenergic receptors (propranolol, 0.05% diet), all noradrenergic receptors (reserpine 5 mg/kg, followed by FLA-63, 25 mg/kg per day), and dopaminergic as well as noradrenergic receptors (chlorpromazine, 5 mg/kg per day).
Positive_regulation (enhanced) of Positive_regulation (response) of cyclase associated with noradrenaline
1) Confidence 0.27 Published 1977 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 909612 Disease Relevance 0 Pain Relevance 0.32
Postnatally with a substantial increase in Gpp[NH]p stimulated adenylyl cyclase activity, the small form (Gs.s) increased in amount while Gs-1 decreased.
Positive_regulation (increased) of Positive_regulation (stimulated) of cyclase
2) Confidence 0.11 Published 1991 Journal FEBS Lett. Section Abstract Doc Link 1652479 Disease Relevance 0 Pain Relevance 0.08
However, the deletion of beta-arrestin-2 does not prevent the chronic morphine-induced up-regulation of adenylyl cyclase activity, a cellular marker of dependence, and the mutant mice still become physically dependent on the drug.
Positive_regulation (morphine-induced) of Positive_regulation (up-regulation) of cyclase associated with addiction and morphine
3) Confidence 0.05 Published 2000 Journal Nature Section Abstract Doc Link 11130073 Disease Relevance 0.29 Pain Relevance 1.19
Pretreatment of intact striatal neurons from the mouse embryo in primary culture with 17 beta-oestradiol (10(-9) M), 24 hours) enhanced the stimulation of adenylate cyclase activity induced by either dopamine (D1 receptors), isoproterenol, serotonin or 2-chloroadenosine (maximal effective concentrations) but suppressed inhibitory responses evoked by agonists of D2-dopaminergic or enkephalin (mu and delta) receptors.
Positive_regulation (enhanced) of Positive_regulation (induced) of cyclase in neurons associated with dopamine, agonist, enkephalin and serotonin
4) Confidence 0.04 Published 1990 Journal Ciba Found. Symp. Section Abstract Doc Link 1963397 Disease Relevance 0 Pain Relevance 0.27
These results suggest that NMDA-produced facilitation of a thermal nociceptive reflex is mediated through activation of an NMDA receptor that results in an increase in endogenous nitric oxide and activation of soluble guanylate cyclase in lumbar spinal cord.
Positive_regulation (results) of Positive_regulation (activation) of cyclase in spinal cord associated with nociception, nmda receptor and spinal cord
5) Confidence 0.04 Published 1992 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1349862 Disease Relevance 0.24 Pain Relevance 0.29
Ni thus appears to mediate guanylate cyclase activation as well as adenylate cyclase inhibition initiated via the same receptors.
Spec (appears) Positive_regulation (mediate) of Positive_regulation (activation) of cyclase
6) Confidence 0.03 Published 1985 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 2986551 Disease Relevance 0.38 Pain Relevance 0.31
Production of endogenous nitric oxide and activation of soluble guanylate cyclase are required for N-methyl-D-aspartate-produced facilitation of the nociceptive tail-flick reflex.
Positive_regulation (required) of Positive_regulation (activation) of cyclase in tail associated with nociception, pain and tail-flick
7) Confidence 0.03 Published 1992 Journal Eur. J. Pharmacol. Section Title Doc Link 1349862 Disease Relevance 0.18 Pain Relevance 0.36
Activation of guanylate cyclase increases platelet cyclic guanosine monophosphate (cGMP), and is accompanied by inhibition of agonist-mediated calcium flux, and, in turn, reduction of fibrinogen binding to the glycoprotein IIb/IIIa receptor.
Positive_regulation (increases) of Positive_regulation (Activation) of cyclase in platelet associated with agonist
8) Confidence 0.03 Published 1992 Journal Am. J. Cardiol. Section Abstract Doc Link 1529922 Disease Relevance 0.15 Pain Relevance 0.17
This suggests that the increase in action potential duration is likely to be mediated by activation of adenylate cyclase.
Spec (likely) Positive_regulation (mediated) of Positive_regulation (activation) of cyclase associated with action potential duration
9) Confidence 0.03 Published 1985 Journal Pflugers Arch. Section Abstract Doc Link 2580271 Disease Relevance 0.10 Pain Relevance 0.36
The CRF1 receptor is a G-protein-coupled receptor (GPCR) that is predominantly linked to the activation of adenylyl cyclase (AC), and also other second messenger systems such as inositol trisphosphate and protein kinase C (PKC; Grammatopoulos et al., 2001; Blank et al., 2003).
Positive_regulation (linked) of Positive_regulation (activation) of cyclase associated with kinase c
10) Confidence 0.03 Published 2011 Journal Frontiers in Neuroscience Section Body Doc Link PMC3024005 Disease Relevance 0.18 Pain Relevance 0.42
These results indicate that testosterone in vivo, while increasing the beta-adrenergic lipolytic action of catecholamines (possibly through enhancement of the adenylate cyclase activity), promotes, to a greater extent, their alpha 2-adrenoreceptor-mediated antilipolytic potency.
Positive_regulation (increasing) of Positive_regulation (enhancement) of cyclase associated with catecholamine and potency
11) Confidence 0.01 Published 1988 Journal Endocrinology Section Abstract Doc Link 2453344 Disease Relevance 0.17 Pain Relevance 0.51
In addition, activation of adenylyl cyclase, with forskolin, and cAMP-dependent protein kinase, with Sp-cAMPS, caused a larger increase in IPSCs in slices from morphine-treated animals.
Positive_regulation (increase) of Positive_regulation (activation) of cyclase associated with morphine
12) Confidence 0.00 Published 1997 Journal J. Neurosci. Section Abstract Doc Link 8987801 Disease Relevance 0.08 Pain Relevance 1.55

General Comments

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