INT39050

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.49
First Reported 1985
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 8.05
Pain Relevance 1.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (PGF) signal transduction (PGF) extracellular region (PGF)
cell-cell signaling (PGF)
Anatomy Link Frequency
musculature 1
chest 1
platelet 1
endometrium 1
placenta 1
PGF (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 47 99.32 Very High Very High Very High
Inflammatory marker 2 88.76 High High
aspirin 40 75.68 Quite High
Pain 6 74.48 Quite High
Clonidine 1 73.76 Quite High
cytokine 33 71.24 Quite High
antagonist 3 68.20 Quite High
metalloproteinase 12 65.60 Quite High
fibrosis 1 61.80 Quite High
lidocaine 1 55.84 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 49 99.32 Very High Very High Very High
Atherosclerosis 9 99.08 Very High Very High Very High
Eclampsia 8 99.00 Very High Very High Very High
Pre-eclampsia 544 98.80 Very High Very High Very High
Rupture 8 98.72 Very High Very High Very High
Myocardial Infarction 78 97.76 Very High Very High Very High
Natriuresis 12 96.12 Very High Very High Very High
Anaplastic Astrocytoma 1 95.76 Very High Very High Very High
Pressure And Volume Under Development 2 94.76 High High
Fibromyalgia 11 94.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We concluded that the IUD did not cause continuous PG release and suggest that close contact of the IUD with the endometrium may prevent the endometrial cells from releasing PGF(2alpha).
Positive_regulation (releasing) of PGF in endometrium
1) Confidence 0.49 Published 2008 Journal Anim. Reprod. Sci. Section Abstract Doc Link 17643876 Disease Relevance 0.12 Pain Relevance 0.06
Increased inflammation was associated with unchanged PGF levels, resulting in an increased ratio of PGE/PGF with increasing inflammation.
Positive_regulation (increased) of PGF associated with inflammation
2) Confidence 0.38 Published 1985 Journal Dig. Dis. Sci. Section Abstract Doc Link 3896701 Disease Relevance 0.97 Pain Relevance 0.49
RESULTS: In patients with ACS, elevated PlGF levels (>27.0 ng/L; 40.8% of patients) indicated a markedly increased risk of events at 30 days (14.8% vs 4.9%; unadjusted hazard ratio [HR], 3.34; 95% confidence interval [CI], 1.79-6.24; P<.001).
Positive_regulation (elevated) of PlGF
3) Confidence 0.31 Published 2004 Journal JAMA Section Body Doc Link 14747500 Disease Relevance 0.07 Pain Relevance 0
In patients with acute chest pain, elevated levels of PlGF predicted risk (21.2% vs 5.3%) (unadjusted: HR, 4.80; 95% CI, 2.81-8.21; P<.001; adjusted: HR, 3.00; 95% CI, 1.68-5.38; P<.001).
Positive_regulation (elevated) of PlGF in chest
4) Confidence 0.31 Published 2004 Journal JAMA Section Body Doc Link 14747500 Disease Relevance 0 Pain Relevance 0
Furthermore, researchers are increasingly finding clinical utility for sVEGFR1, either independently or in combination with circulating VEGF or PlGF, as diagnostic and prognostic markers for a diversity of angiogenesis-dependent medical conditions: from astrocytic gliomas [37], primary breast cancer [38], acute myeloid leukemia [39], to sepsis [40], and pre-eclampsia [41], [42].
Positive_regulation (circulating) of PlGF associated with anaplastic astrocytoma, leukemia, breast cancer, eclampsia and sepsis
5) Confidence 0.30 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663039 Disease Relevance 1.39 Pain Relevance 0.11
It was proposed that the triggering of adenyl cyclase could determine an activation of COX-2, which in turn should induce an increase of the synthesis of either prostaglandin (PG)E, with an ensuing muscle relaxation, or PGF, which determines the contraction of the uterine musculature [28].
Spec (determine) Positive_regulation (activation) of PGF in musculature
6) Confidence 0.27 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2913851 Disease Relevance 0 Pain Relevance 0
Intramyocardial transplantation of EPC after AMI induces significant and sustained increase in angiogenic, antiapoptotic, and chemoattractant factors, that are upregulated in both transplanted and host cells (i.e., vascular endothelial growth factor-A [VEGF-A], fibroblast growth factor-2 [FGF-2], angiopoietin-1 [Ang-1], angiopoietin-2 [Ang-2], placenta growth factor [PIGF], hepatocyte growth factor [HGF], insulin-like growth factor-1 [IGF-1], platelet-derived growth factor-B [PDGF-B], and stromal cell-derived factor-1 [SDF-1]) [35].
Positive_regulation (upregulated) of placenta growth factor in platelet associated with myocardial infarction
7) Confidence 0.13 Published 2010 Journal Stem Cells International Section Body Doc Link PMC2975079 Disease Relevance 0.62 Pain Relevance 0.33
Soluble Flt-1 binds to circulating free vascular endothelial growth factor and placenta growth factor and this is associated with endothelial dysfunction.
Positive_regulation (circulating) of placenta growth factor in placenta
8) Confidence 0.11 Published 2009 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 19215236 Disease Relevance 0.34 Pain Relevance 0.07
The pattern of elevated concentrations of sFlt1 and sEng, and low PlGF in high-risk pregnant subjects who develop preeclampsia is similar to that reported in low-risk pregnant women.
Positive_regulation (elevated) of PlGF associated with pre-eclampsia
9) Confidence 0.09 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2952583 Disease Relevance 0.92 Pain Relevance 0.03
A study by the same group also reported that maternal serum sFlt1 and PlGF are significantly elevated in subjects with multifetal gestations as early as 22 weeks' gestation [15].
Positive_regulation (elevated) of PlGF
10) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2952583 Disease Relevance 0.79 Pain Relevance 0
The odds of developing preeclampsia were significantly increased for each 2-fold elevation in sFlt1, sEng and the angiogenic factor ratio, and were significantly decreased for each 2-fold elevation in PlGF at study entry in subjects with multifetal gestations.
Positive_regulation (elevation) of PlGF associated with pre-eclampsia
11) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2952583 Disease Relevance 0.69 Pain Relevance 0
OR 2.18, 95% CI 1.46-3.32), and significantly decreased for each 2-fold elevation in circulating PlGF (OR 0.50, 95% CI 0.30-0.82) between 7 and 26 weeks' gestation.
Positive_regulation (elevation) of PlGF
12) Confidence 0.09 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2952583 Disease Relevance 0.98 Pain Relevance 0.04
This assumption is further supported by the high levels of angiogenic growth factor (Vascular Endothelial Growth Factor C, Placental Growth Factor, Angiopoietin-1 and 2, Transforming Growth Factor -?)
Positive_regulation (levels) of Placental Growth Factor
13) Confidence 0.06 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017546 Disease Relevance 0 Pain Relevance 0.10
The percentages of neutrophils, fibrinogen, albumin, PGE2, PGF2 alpha, and kinins were elevated in BALF after O3 compared with FA.
Positive_regulation (elevated) of PGF2 in neutrophils
14) Confidence 0.04 Published 1995 Journal Am. J. Respir. Crit. Care Med. Section Abstract Doc Link 7551367 Disease Relevance 0.16 Pain Relevance 0.14
Placental growth factor (PIGF), a member of the vascular endothelial growth factor (VEGF) family, was shown to be profoundly upregulated in early and advanced atherosclerotic lesions (Luttun A et al. 2002).
Positive_regulation (upregulated) of Placental growth factor associated with atherosclerosis
15) Confidence 0.03 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2688349 Disease Relevance 0.99 Pain Relevance 0.06

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox