INT39060

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Context Info
Confidence 0.77
First Reported 1985
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 45
Total Number 47
Disease Relevance 21.55
Pain Relevance 4.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neurons 4
striatum 2
sympathetic 2
retina 1
primary neurons 1
Mpz (Mus musculus)
Pain Link Frequency Relevance Heat
Neuritis 32 99.28 Very High Very High Very High
Demyelination 2 99.08 Very High Very High Very High
Inflammatory mediators 54 98.96 Very High Very High Very High
Dopamine 86 98.52 Very High Very High Very High
gABA 10 96.74 Very High Very High Very High
Sciatic nerve 6 94.48 High High
induced neuropathy 2 94.08 High High
vincristine 11 93.28 High High
imagery 29 93.00 High High
monoamine 11 92.00 High High
Disease Link Frequency Relevance Heat
Parkinson's Disease 691 100.00 Very High Very High Very High
Adhesions 40 100.00 Very High Very High Very High
Death 347 99.96 Very High Very High Very High
Disease 510 99.84 Very High Very High Very High
Targeted Disruption 151 99.64 Very High Very High Very High
Toxicity 141 99.56 Very High Very High Very High
Myeloproliferative Disorder 66 99.52 Very High Very High Very High
Experimental Autoimmune Neuritis 24 99.28 Very High Very High Very High
Demyelinating Disease 12 99.08 Very High Very High Very High
INFLAMMATION 424 98.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To our knowledge expression of the MPZ alleles is unknown.
Gene_expression (expression) of MPZ
1) Confidence 0.77 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2861067 Disease Relevance 1.06 Pain Relevance 0.15
These mice produce only 50% of the major myelin protein protein zero (P0) and display signs of demyelination in motor nerves at 4 months of age.
Gene_expression (produce) of P0 in motor nerves associated with demyelination
2) Confidence 0.76 Published 2006 Journal J. Neurosci. Res. Section Abstract Doc Link 16676325 Disease Relevance 0.65 Pain Relevance 0.39
Phenotype related to MPZ protein structure
Gene_expression (structure) of MPZ protein
3) Confidence 0.67 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2861067 Disease Relevance 0.81 Pain Relevance 0
When NRG1 is presented to Schwann cells in the context of cell-cell contact, type III but not type I NRG1 regulates P0 gene expression.
Gene_expression (expression) of P0 gene in Schwann cells
4) Confidence 0.65 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16554459 Disease Relevance 0.14 Pain Relevance 0.13
Furthermore, we found that the effects of NRG1 on P0 expression depend on the NRG1 isoform used.
Gene_expression (expression) of P0
5) Confidence 0.65 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16554459 Disease Relevance 0.15 Pain Relevance 0.12
In vitro assays revealed that neuregulin-1 (NRG1) induces expression of myelin protein zero (P0).
Gene_expression (expression) of P0
6) Confidence 0.65 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16554459 Disease Relevance 0.16 Pain Relevance 0.12
in MPTP/MPP+-mediated neuronal cell death and we showed that differential GSK-3?
Gene_expression (/) of MPP in neuronal associated with parkinson's disease and death
7) Confidence 0.61 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2675062 Disease Relevance 0.83 Pain Relevance 0
Overall, MPTP/MPP+ induced the activation of GSK-3?
Gene_expression (/) of MPP associated with parkinson's disease
8) Confidence 0.61 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2675062 Disease Relevance 1.07 Pain Relevance 0.11
in MPTP/MPP+-induced mitochondrial dysfunction and dopaminergic neuronal death, in vivo, as well as in primary cultures of neuronal cells and immortalized neurons.
Gene_expression (dysfunction) of MPP+-induced in neurons associated with parkinson's disease and death
9) Confidence 0.61 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2675062 Disease Relevance 1.23 Pain Relevance 0.12
Striatal MPP+ levels do not necessarily correlate with striatal dopamine levels after MPTP treatment in mice.
Gene_expression (levels) of MPP associated with parkinson's disease and dopamine
10) Confidence 0.59 Published 1996 Journal Neurodegeneration Section Title Doc Link 8819133 Disease Relevance 0.55 Pain Relevance 0.15
HeLa cells tranfected with two late onset and two early onset MPZ mutations showed that the two late onset mutations had normal transportation of the P0 to the cell membrane and moderately reduced MPZ-mediated intercellular adhesion, while the two early onset mutations had different patterns [23].
Gene_expression (adhesion) of MPZ-mediated in HeLa associated with adhesions
11) Confidence 0.59 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2861067 Disease Relevance 0.46 Pain Relevance 0
Here, we show that GABA(B1)-deficient mice exhibit morphological and molecular changes in peripheral myelin, including an increase in the number of irregular fibers and increases in the expression levels of the myelin proteins PMP22 and P0.
Gene_expression (expression) of P0 associated with gaba
12) Confidence 0.54 Published 2008 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 18206390 Disease Relevance 0.08 Pain Relevance 0.62
Immortalized murine cortical neurons (TSM1) or primary cultures of neuronal cells were incubated in the presence of MPP+ iodide then Western blot analyses were performed on neuron homogenates in order to examine the effect of MPP+ on the phosphorylation of GSK-3?
Gene_expression (iodide) of MPP in neurons
13) Confidence 0.54 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2675062 Disease Relevance 0.55 Pain Relevance 0
Co-treatment with 25 mM LiCl or 25 µM kenpaullone significantly protected TSM1 from the MPP+-induced death (Figure 2C).
Gene_expression (protected) of MPP+-induced associated with death
14) Confidence 0.54 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2675062 Disease Relevance 0.51 Pain Relevance 0.07
Surprisingly, the MPP+-induced GSK-3?
Gene_expression (Surprisingly) of MPP+-induced
15) Confidence 0.54 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2675062 Disease Relevance 0.23 Pain Relevance 0
Treatment of TSM1 cells and primary neurons with 400 µM MPP+ decreased by ?
Gene_expression (primary neurons) of MPP in primary neurons
16) Confidence 0.54 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2675062 Disease Relevance 0.57 Pain Relevance 0.08
This protective effect is accompanied by an almost complete prevention of MPP+ production induced by (-) deprenyl and an accelerated MPP+ clearance induced by GBR-12909 within the striatum.
Gene_expression (production) of MPP in striatum
17) Confidence 0.52 Published 1996 Journal Neurodegeneration Section Abstract Doc Link 8819133 Disease Relevance 0.49 Pain Relevance 0.12
Knock-out mice without P0 expression develop a severe dysmyelinating neuropathy with predominantly uncompacted myelin [13].
Gene_expression (expression) of P0 associated with targeted disruption and neuropathic pain
18) Confidence 0.52 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2861067 Disease Relevance 0.75 Pain Relevance 0.04
Differential analysis of P0 WT versus P0 TrkA mutant mice libraries
Gene_expression (versus) of P0
19) Confidence 0.52 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2241628 Disease Relevance 0 Pain Relevance 0
When expressed as "fold-change in expression" the SAGE results demonstrate a down regulation of Grik1, Dock4 and Crip2 expression between P0 WT and P0 Trka-/- DRG of about 18, 6 and 3 fold respectively, while QRT-PCR provided an expression ratio between P0 WT and P0 Trka-/- DRG of 17, 4 and 4 fold respectively.


Gene_expression (expression) of P0
20) Confidence 0.52 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2241628 Disease Relevance 0.13 Pain Relevance 0.16

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